Airway exposure to TiO2 nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Airway exposure to TiO2 nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice. / Lauvås, Anna Jacobsen; Skovmand, Astrid; Poulsen, Marie Sønnegaard; Kyjovska, Zdenka Orabi; Roursgaard, Martin; Goericke-Pesch, Sandra; Vogel, Ulla; Hougaard, Karin Sørig.

In: Reproductive Toxicology, Vol. 90, 2019, p. 134-140.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lauvås, AJ, Skovmand, A, Poulsen, MS, Kyjovska, ZO, Roursgaard, M, Goericke-Pesch, S, Vogel, U & Hougaard, KS 2019, 'Airway exposure to TiO2 nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice', Reproductive Toxicology, vol. 90, pp. 134-140. https://doi.org/10.1016/j.reprotox.2019.07.023

APA

Lauvås, A. J., Skovmand, A., Poulsen, M. S., Kyjovska, Z. O., Roursgaard, M., Goericke-Pesch, S., Vogel, U., & Hougaard, K. S. (2019). Airway exposure to TiO2 nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice. Reproductive Toxicology, 90, 134-140. https://doi.org/10.1016/j.reprotox.2019.07.023

Vancouver

Lauvås AJ, Skovmand A, Poulsen MS, Kyjovska ZO, Roursgaard M, Goericke-Pesch S et al. Airway exposure to TiO2 nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice. Reproductive Toxicology. 2019;90:134-140. https://doi.org/10.1016/j.reprotox.2019.07.023

Author

Lauvås, Anna Jacobsen ; Skovmand, Astrid ; Poulsen, Marie Sønnegaard ; Kyjovska, Zdenka Orabi ; Roursgaard, Martin ; Goericke-Pesch, Sandra ; Vogel, Ulla ; Hougaard, Karin Sørig. / Airway exposure to TiO2 nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice. In: Reproductive Toxicology. 2019 ; Vol. 90. pp. 134-140.

Bibtex

@article{1e7e944809694d9eb5be7033373fdda2,
title = "Airway exposure to TiO2 nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice",
abstract = "Several types of engineered nanoparticles (ENP) have been shown to adversely affect male reproduction in rodent studies, but the airway route of exposure has been little investigated. This precludes adequate risk assessment of ENP exposure in occupational settings. Titanium dioxide nanoparticles (TiO2 NP) have been shown to affect total sperm count in adult male mice after intravenous and oral administration. This study aimed to investigate whether also airway exposure would affect sperm counts in male mice. Mature C57BL/6J mice were intratracheally instilled with 63 μg of rutile nanosized TiO2, once weekly for seven weeks. Respirable α-quartz (SRM1878a) was included at a similar dose level as a positive control for pulmonary inflammation. BALF cell composition showed neutrophil granulocyte influx as indication of pulmonary inflammation in animals exposed to TiO2 NP and α-quartz, but none of the particle exposures affected weight of testes or the epididymis, sperm counts or plasma testosterone when assessed at termination of the study.",
keywords = "Airways, Inflammation, Intratracheal instillation, Reproduction, Sperm, Testosterone, Titanium dioxide",
author = "Lauv{\aa}s, {Anna Jacobsen} and Astrid Skovmand and Poulsen, {Marie S{\o}nnegaard} and Kyjovska, {Zdenka Orabi} and Martin Roursgaard and Sandra Goericke-Pesch and Ulla Vogel and Hougaard, {Karin S{\o}rig}",
year = "2019",
doi = "10.1016/j.reprotox.2019.07.023",
language = "English",
volume = "90",
pages = "134--140",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Airway exposure to TiO2 nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice

AU - Lauvås, Anna Jacobsen

AU - Skovmand, Astrid

AU - Poulsen, Marie Sønnegaard

AU - Kyjovska, Zdenka Orabi

AU - Roursgaard, Martin

AU - Goericke-Pesch, Sandra

AU - Vogel, Ulla

AU - Hougaard, Karin Sørig

PY - 2019

Y1 - 2019

N2 - Several types of engineered nanoparticles (ENP) have been shown to adversely affect male reproduction in rodent studies, but the airway route of exposure has been little investigated. This precludes adequate risk assessment of ENP exposure in occupational settings. Titanium dioxide nanoparticles (TiO2 NP) have been shown to affect total sperm count in adult male mice after intravenous and oral administration. This study aimed to investigate whether also airway exposure would affect sperm counts in male mice. Mature C57BL/6J mice were intratracheally instilled with 63 μg of rutile nanosized TiO2, once weekly for seven weeks. Respirable α-quartz (SRM1878a) was included at a similar dose level as a positive control for pulmonary inflammation. BALF cell composition showed neutrophil granulocyte influx as indication of pulmonary inflammation in animals exposed to TiO2 NP and α-quartz, but none of the particle exposures affected weight of testes or the epididymis, sperm counts or plasma testosterone when assessed at termination of the study.

AB - Several types of engineered nanoparticles (ENP) have been shown to adversely affect male reproduction in rodent studies, but the airway route of exposure has been little investigated. This precludes adequate risk assessment of ENP exposure in occupational settings. Titanium dioxide nanoparticles (TiO2 NP) have been shown to affect total sperm count in adult male mice after intravenous and oral administration. This study aimed to investigate whether also airway exposure would affect sperm counts in male mice. Mature C57BL/6J mice were intratracheally instilled with 63 μg of rutile nanosized TiO2, once weekly for seven weeks. Respirable α-quartz (SRM1878a) was included at a similar dose level as a positive control for pulmonary inflammation. BALF cell composition showed neutrophil granulocyte influx as indication of pulmonary inflammation in animals exposed to TiO2 NP and α-quartz, but none of the particle exposures affected weight of testes or the epididymis, sperm counts or plasma testosterone when assessed at termination of the study.

KW - Airways

KW - Inflammation

KW - Intratracheal instillation

KW - Reproduction

KW - Sperm

KW - Testosterone

KW - Titanium dioxide

U2 - 10.1016/j.reprotox.2019.07.023

DO - 10.1016/j.reprotox.2019.07.023

M3 - Journal article

C2 - 31449912

AN - SCOPUS:85072707336

VL - 90

SP - 134

EP - 140

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

ER -

ID: 228491973