Associations between dietary amino acid intakes and blood concentration levels

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Associations between dietary amino acid intakes and blood concentration levels. / Iguacel, Isabel; Schmidt, Julie A; Perez-Cornago, Aurora; Van Puyvelde, Heleen; Travis, Ruth; Stepien, Magdalena; Scalbert, Augustin; Casagrande, Corinne; Weiderpass, Elisabete; Riboli, Elio; Schulze, Matthias B; Skeie, Guri; Bodén, Stina; Boeing, Heiner; Cross, Amanda J; Harlid, Sophia; Jensen, Torill Enget; Huerta, José M; Katzke, Verena; Kühn, Tilman; Lujan-Barroso, Leila; Masala, Giovanna; Rodriguez-Barranco, Miguel; Rostgaard-Hansen, Agnetha Linn; van der Schouw, Yvonne T; Vermeulen, Roel; Tagliabue, Giovanna; Tjønneland, Anne; Trevisan, Morena; Ferrari, Pietro; Gunter, Marc J; Huybrechts, Inge.

In: Clinical Nutrition, Vol. 40, No. 6, 2021, p. 3772-3779.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Iguacel, I, Schmidt, JA, Perez-Cornago, A, Van Puyvelde, H, Travis, R, Stepien, M, Scalbert, A, Casagrande, C, Weiderpass, E, Riboli, E, Schulze, MB, Skeie, G, Bodén, S, Boeing, H, Cross, AJ, Harlid, S, Jensen, TE, Huerta, JM, Katzke, V, Kühn, T, Lujan-Barroso, L, Masala, G, Rodriguez-Barranco, M, Rostgaard-Hansen, AL, van der Schouw, YT, Vermeulen, R, Tagliabue, G, Tjønneland, A, Trevisan, M, Ferrari, P, Gunter, MJ & Huybrechts, I 2021, 'Associations between dietary amino acid intakes and blood concentration levels', Clinical Nutrition, vol. 40, no. 6, pp. 3772-3779. https://doi.org/10.1016/j.clnu.2021.04.036

APA

Iguacel, I., Schmidt, J. A., Perez-Cornago, A., Van Puyvelde, H., Travis, R., Stepien, M., Scalbert, A., Casagrande, C., Weiderpass, E., Riboli, E., Schulze, M. B., Skeie, G., Bodén, S., Boeing, H., Cross, A. J., Harlid, S., Jensen, T. E., Huerta, J. M., Katzke, V., ... Huybrechts, I. (2021). Associations between dietary amino acid intakes and blood concentration levels. Clinical Nutrition, 40(6), 3772-3779. https://doi.org/10.1016/j.clnu.2021.04.036

Vancouver

Iguacel I, Schmidt JA, Perez-Cornago A, Van Puyvelde H, Travis R, Stepien M et al. Associations between dietary amino acid intakes and blood concentration levels. Clinical Nutrition. 2021;40(6):3772-3779. https://doi.org/10.1016/j.clnu.2021.04.036

Author

Iguacel, Isabel ; Schmidt, Julie A ; Perez-Cornago, Aurora ; Van Puyvelde, Heleen ; Travis, Ruth ; Stepien, Magdalena ; Scalbert, Augustin ; Casagrande, Corinne ; Weiderpass, Elisabete ; Riboli, Elio ; Schulze, Matthias B ; Skeie, Guri ; Bodén, Stina ; Boeing, Heiner ; Cross, Amanda J ; Harlid, Sophia ; Jensen, Torill Enget ; Huerta, José M ; Katzke, Verena ; Kühn, Tilman ; Lujan-Barroso, Leila ; Masala, Giovanna ; Rodriguez-Barranco, Miguel ; Rostgaard-Hansen, Agnetha Linn ; van der Schouw, Yvonne T ; Vermeulen, Roel ; Tagliabue, Giovanna ; Tjønneland, Anne ; Trevisan, Morena ; Ferrari, Pietro ; Gunter, Marc J ; Huybrechts, Inge. / Associations between dietary amino acid intakes and blood concentration levels. In: Clinical Nutrition. 2021 ; Vol. 40, No. 6. pp. 3772-3779.

Bibtex

@article{6d42741e717746e29f2e262be2241d04,
title = "Associations between dietary amino acid intakes and blood concentration levels",
abstract = "Background and aims: Emerging evidence suggests a role of amino acids (AAs) in the development of various diseases including renal failure, liver cirrhosis, diabetes and cancer. However, mechanistic pathways and the effects of dietary AA intakes on circulating levels and disease outcomes are unclear. We aimed to compare protein and AA intakes, with their respective blood concentrations in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Dietary protein and AA intakes were assessed via the EPIC dietary questionnaires (DQ) and 24-h dietary recalls (24-HDR). A subsample of 3768 EPIC participants who were free of cancer had blood AA concentrations measured. To investigate how circulating levels relate to their respective intakes, dietary AA intake was examined in quintiles and ANOVA tests were run. Pearson correlations were examined for continous associations between intakes and blood concentrations. Results: Dietary AA intakes (assessed with the DQ) and blood AA concentrations were not strongly correlated (−0.15 ≤ r ≤ 0.17) and the direction of the correlations depended on AA class: weak positive correlations were found for most essential AAs (isoleucine, leucine, lysine, methionine, threonine, tryptophan, and valine) and conditionally essential AAs (arginine and tyrosine), while negative associations were found for non-essential AAs. Similar results were found when using the 24-HDR. When conducting ANOVA tests for essential AAs, higher intake quintiles were linked to higher blood AA concentrations, except for histidine and phenylalanine. For non-essential AAs and glycine, an inverse relationship was observed. Conditionally-essential AAs showed mixed results. Conclusions: Weak positive correlations and dose responses were found between most essential and conditionally essential AA intakes, and blood concentrations, but not for the non-essential AAs. These results suggest that intake of dietary AA might be related to physiological AA status, particularly for the essential AAs. However, these results should be further evaluated and confirmed in large-scale prospective studies.",
keywords = "24-H dietary recall, Amino acids, Blood levels, Dietary intake, Dietary questionnaire",
author = "Isabel Iguacel and Schmidt, {Julie A} and Aurora Perez-Cornago and {Van Puyvelde}, Heleen and Ruth Travis and Magdalena Stepien and Augustin Scalbert and Corinne Casagrande and Elisabete Weiderpass and Elio Riboli and Schulze, {Matthias B} and Guri Skeie and Stina Bod{\'e}n and Heiner Boeing and Cross, {Amanda J} and Sophia Harlid and Jensen, {Torill Enget} and Huerta, {Jos{\'e} M} and Verena Katzke and Tilman K{\"u}hn and Leila Lujan-Barroso and Giovanna Masala and Miguel Rodriguez-Barranco and Rostgaard-Hansen, {Agnetha Linn} and {van der Schouw}, {Yvonne T} and Roel Vermeulen and Giovanna Tagliabue and Anne Tj{\o}nneland and Morena Trevisan and Pietro Ferrari and Gunter, {Marc J} and Inge Huybrechts",
note = "Publisher Copyright: {\textcopyright} 2021",
year = "2021",
doi = "10.1016/j.clnu.2021.04.036",
language = "English",
volume = "40",
pages = "3772--3779",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Associations between dietary amino acid intakes and blood concentration levels

AU - Iguacel, Isabel

AU - Schmidt, Julie A

AU - Perez-Cornago, Aurora

AU - Van Puyvelde, Heleen

AU - Travis, Ruth

AU - Stepien, Magdalena

AU - Scalbert, Augustin

AU - Casagrande, Corinne

AU - Weiderpass, Elisabete

AU - Riboli, Elio

AU - Schulze, Matthias B

AU - Skeie, Guri

AU - Bodén, Stina

AU - Boeing, Heiner

AU - Cross, Amanda J

AU - Harlid, Sophia

AU - Jensen, Torill Enget

AU - Huerta, José M

AU - Katzke, Verena

AU - Kühn, Tilman

AU - Lujan-Barroso, Leila

AU - Masala, Giovanna

AU - Rodriguez-Barranco, Miguel

AU - Rostgaard-Hansen, Agnetha Linn

AU - van der Schouw, Yvonne T

AU - Vermeulen, Roel

AU - Tagliabue, Giovanna

AU - Tjønneland, Anne

AU - Trevisan, Morena

AU - Ferrari, Pietro

AU - Gunter, Marc J

AU - Huybrechts, Inge

N1 - Publisher Copyright: © 2021

PY - 2021

Y1 - 2021

N2 - Background and aims: Emerging evidence suggests a role of amino acids (AAs) in the development of various diseases including renal failure, liver cirrhosis, diabetes and cancer. However, mechanistic pathways and the effects of dietary AA intakes on circulating levels and disease outcomes are unclear. We aimed to compare protein and AA intakes, with their respective blood concentrations in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Dietary protein and AA intakes were assessed via the EPIC dietary questionnaires (DQ) and 24-h dietary recalls (24-HDR). A subsample of 3768 EPIC participants who were free of cancer had blood AA concentrations measured. To investigate how circulating levels relate to their respective intakes, dietary AA intake was examined in quintiles and ANOVA tests were run. Pearson correlations were examined for continous associations between intakes and blood concentrations. Results: Dietary AA intakes (assessed with the DQ) and blood AA concentrations were not strongly correlated (−0.15 ≤ r ≤ 0.17) and the direction of the correlations depended on AA class: weak positive correlations were found for most essential AAs (isoleucine, leucine, lysine, methionine, threonine, tryptophan, and valine) and conditionally essential AAs (arginine and tyrosine), while negative associations were found for non-essential AAs. Similar results were found when using the 24-HDR. When conducting ANOVA tests for essential AAs, higher intake quintiles were linked to higher blood AA concentrations, except for histidine and phenylalanine. For non-essential AAs and glycine, an inverse relationship was observed. Conditionally-essential AAs showed mixed results. Conclusions: Weak positive correlations and dose responses were found between most essential and conditionally essential AA intakes, and blood concentrations, but not for the non-essential AAs. These results suggest that intake of dietary AA might be related to physiological AA status, particularly for the essential AAs. However, these results should be further evaluated and confirmed in large-scale prospective studies.

AB - Background and aims: Emerging evidence suggests a role of amino acids (AAs) in the development of various diseases including renal failure, liver cirrhosis, diabetes and cancer. However, mechanistic pathways and the effects of dietary AA intakes on circulating levels and disease outcomes are unclear. We aimed to compare protein and AA intakes, with their respective blood concentrations in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Dietary protein and AA intakes were assessed via the EPIC dietary questionnaires (DQ) and 24-h dietary recalls (24-HDR). A subsample of 3768 EPIC participants who were free of cancer had blood AA concentrations measured. To investigate how circulating levels relate to their respective intakes, dietary AA intake was examined in quintiles and ANOVA tests were run. Pearson correlations were examined for continous associations between intakes and blood concentrations. Results: Dietary AA intakes (assessed with the DQ) and blood AA concentrations were not strongly correlated (−0.15 ≤ r ≤ 0.17) and the direction of the correlations depended on AA class: weak positive correlations were found for most essential AAs (isoleucine, leucine, lysine, methionine, threonine, tryptophan, and valine) and conditionally essential AAs (arginine and tyrosine), while negative associations were found for non-essential AAs. Similar results were found when using the 24-HDR. When conducting ANOVA tests for essential AAs, higher intake quintiles were linked to higher blood AA concentrations, except for histidine and phenylalanine. For non-essential AAs and glycine, an inverse relationship was observed. Conditionally-essential AAs showed mixed results. Conclusions: Weak positive correlations and dose responses were found between most essential and conditionally essential AA intakes, and blood concentrations, but not for the non-essential AAs. These results suggest that intake of dietary AA might be related to physiological AA status, particularly for the essential AAs. However, these results should be further evaluated and confirmed in large-scale prospective studies.

KW - 24-H dietary recall

KW - Amino acids

KW - Blood levels

KW - Dietary intake

KW - Dietary questionnaire

U2 - 10.1016/j.clnu.2021.04.036

DO - 10.1016/j.clnu.2021.04.036

M3 - Journal article

C2 - 34130023

AN - SCOPUS:85107738866

VL - 40

SP - 3772

EP - 3779

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 6

ER -

ID: 273637319