Asthma-inducing potential of 28 substances in spray cleaning products-Assessed by quantitative structure activity relationship (QSAR) testing and literature review
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Asthma-inducing potential of 28 substances in spray cleaning products-Assessed by quantitative structure activity relationship (QSAR) testing and literature review. / Hadrup, Niels; Frederiksen, Marie; Wedebye, Eva Bay; Nikolov, Nikolai G.; Carøe, Tanja K.; Sorli, Jorid B.; Frydendall, Karen B.; Liguori, Biase; Sejbaek, Camilla S.; Wolkoff, Peder; Flachs, Esben M.; Schlunssen, Vivi; Meyer, Harald W.; Clausen, Per A.; Hougaard, Karin S.
In: Journal of Applied Toxicology, Vol. 42, No. 1, 2021, p. 130-153.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Asthma-inducing potential of 28 substances in spray cleaning products-Assessed by quantitative structure activity relationship (QSAR) testing and literature review
AU - Hadrup, Niels
AU - Frederiksen, Marie
AU - Wedebye, Eva Bay
AU - Nikolov, Nikolai G.
AU - Carøe, Tanja K.
AU - Sorli, Jorid B.
AU - Frydendall, Karen B.
AU - Liguori, Biase
AU - Sejbaek, Camilla S.
AU - Wolkoff, Peder
AU - Flachs, Esben M.
AU - Schlunssen, Vivi
AU - Meyer, Harald W.
AU - Clausen, Per A.
AU - Hougaard, Karin S.
PY - 2021
Y1 - 2021
N2 - Exposure to spray cleaning products constitutes a potential risk for asthma induction. We set out to review whether substances in such products are potential inducers of asthma. We identified 101 spray cleaning products for professional use. Twenty-eight of their chemical substances were selected. We based the selection on (a) positive prediction for respiratory sensitisation in humans based on quantitative structure activity relationship (QSAR) in the Danish (Q)SAR Database, (b) positive QSAR prediction for severe skin irritation in rabbits and (c) knowledge on the substances' physico-chemical characteristics and toxicity. Combining the findings in the literature and QSAR predictions, we could group substances into four classes: (1) some indication in humans for asthma induction: chloramine, benzalkonium chloride; (2) some indication in animals for asthma induction: ethylenediaminetetraacetic acid (EDTA), citric acid; (3) equivocal data: hypochlorite; (4) few or lacking data: nitriloacetic acid, monoethanolamine, 2-(2-aminoethoxy)ethanol, 2-diethylaminoethanol, alkyldimethylamin oxide, 1-aminopropan-2-ol, methylisothiazolinone, benzisothiazolinone and chlormethylisothiazolinone; three specific sulphonates and sulfamic acid, salicylic acid and its analogue sodium benzoate, propane-1,2-diol, glycerol, propylidynetrimethanol, lactic acid, disodium malate, morpholine, bronopol and benzyl alcohol. In conclusion, we identified an asthma induction potential for some of the substances. In addition, we identified major knowledge gaps for most substances. Thus, more data are needed to feed into a strategy of safe-by-design, where substances with potential for induction of asthma are avoided in future (spray) cleaning products. Moreover, we suggest that QSAR predictions can serve to prioritise substances that need further testing in various areas of toxicology.
AB - Exposure to spray cleaning products constitutes a potential risk for asthma induction. We set out to review whether substances in such products are potential inducers of asthma. We identified 101 spray cleaning products for professional use. Twenty-eight of their chemical substances were selected. We based the selection on (a) positive prediction for respiratory sensitisation in humans based on quantitative structure activity relationship (QSAR) in the Danish (Q)SAR Database, (b) positive QSAR prediction for severe skin irritation in rabbits and (c) knowledge on the substances' physico-chemical characteristics and toxicity. Combining the findings in the literature and QSAR predictions, we could group substances into four classes: (1) some indication in humans for asthma induction: chloramine, benzalkonium chloride; (2) some indication in animals for asthma induction: ethylenediaminetetraacetic acid (EDTA), citric acid; (3) equivocal data: hypochlorite; (4) few or lacking data: nitriloacetic acid, monoethanolamine, 2-(2-aminoethoxy)ethanol, 2-diethylaminoethanol, alkyldimethylamin oxide, 1-aminopropan-2-ol, methylisothiazolinone, benzisothiazolinone and chlormethylisothiazolinone; three specific sulphonates and sulfamic acid, salicylic acid and its analogue sodium benzoate, propane-1,2-diol, glycerol, propylidynetrimethanol, lactic acid, disodium malate, morpholine, bronopol and benzyl alcohol. In conclusion, we identified an asthma induction potential for some of the substances. In addition, we identified major knowledge gaps for most substances. Thus, more data are needed to feed into a strategy of safe-by-design, where substances with potential for induction of asthma are avoided in future (spray) cleaning products. Moreover, we suggest that QSAR predictions can serve to prioritise substances that need further testing in various areas of toxicology.
KW - asthma
KW - chemical
KW - in silico
KW - inhalation
KW - QSAR
KW - sensitisation
KW - toxicology
KW - CHLORIDE-INDUCED BRONCHOCONSTRICTION
KW - ALLERGIC CONTACT-DERMATITIS
KW - ACID-INDUCED COUGH
KW - BENZALKONIUM CHLORIDE
KW - OCCUPATIONAL ASTHMA
KW - CHLORAMINE-T
KW - AIRWAY HYPERRESPONSIVENESS
KW - INHALATION TOXICITY
KW - IPRATROPIUM BROMIDE
KW - EXPOSURE
U2 - 10.1002/jat.4215
DO - 10.1002/jat.4215
M3 - Review
C2 - 34247391
VL - 42
SP - 130
EP - 153
JO - Journal of Applied Toxicology
JF - Journal of Applied Toxicology
SN - 0260-437X
IS - 1
ER -
ID: 274427690