Autonomic nervous system activity in primary Raynaud's phenomenon: Heart rate variability, plasma catecholamines and [123I]MIBG heart scintigraphy

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Autonomic nervous system activity in primary Raynaud's phenomenon : Heart rate variability, plasma catecholamines and [123I]MIBG heart scintigraphy. / Lindberg, Lotte; Brinth, Louise S.; Bergmann, Marianne L.; Kristensen, Bent; Hansen, Tine W.; Hasbak, Philip; Thomsen, Jane F.; Eldrup, Ebbe; Jensen, Lars T.

In: Clinical Physiology and Functional Imaging, Vol. 42, No. 2, 2022, p. 104-113.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lindberg, L, Brinth, LS, Bergmann, ML, Kristensen, B, Hansen, TW, Hasbak, P, Thomsen, JF, Eldrup, E & Jensen, LT 2022, 'Autonomic nervous system activity in primary Raynaud's phenomenon: Heart rate variability, plasma catecholamines and [123I]MIBG heart scintigraphy', Clinical Physiology and Functional Imaging, vol. 42, no. 2, pp. 104-113. https://doi.org/10.1111/cpf.12737

APA

Lindberg, L., Brinth, L. S., Bergmann, M. L., Kristensen, B., Hansen, T. W., Hasbak, P., Thomsen, J. F., Eldrup, E., & Jensen, L. T. (2022). Autonomic nervous system activity in primary Raynaud's phenomenon: Heart rate variability, plasma catecholamines and [123I]MIBG heart scintigraphy. Clinical Physiology and Functional Imaging, 42(2), 104-113. https://doi.org/10.1111/cpf.12737

Vancouver

Lindberg L, Brinth LS, Bergmann ML, Kristensen B, Hansen TW, Hasbak P et al. Autonomic nervous system activity in primary Raynaud's phenomenon: Heart rate variability, plasma catecholamines and [123I]MIBG heart scintigraphy. Clinical Physiology and Functional Imaging. 2022;42(2):104-113. https://doi.org/10.1111/cpf.12737

Author

Lindberg, Lotte ; Brinth, Louise S. ; Bergmann, Marianne L. ; Kristensen, Bent ; Hansen, Tine W. ; Hasbak, Philip ; Thomsen, Jane F. ; Eldrup, Ebbe ; Jensen, Lars T. / Autonomic nervous system activity in primary Raynaud's phenomenon : Heart rate variability, plasma catecholamines and [123I]MIBG heart scintigraphy. In: Clinical Physiology and Functional Imaging. 2022 ; Vol. 42, No. 2. pp. 104-113.

Bibtex

@article{95474500990d418d8bfa0b74594f9ae1,
title = "Autonomic nervous system activity in primary Raynaud's phenomenon: Heart rate variability, plasma catecholamines and [123I]MIBG heart scintigraphy",
abstract = "Background and Aim: Primary Raynaud's phenomenon (pRP) is characterized by an exaggerated response to cold, resulting in the whitening typically of the fingers and toes. The patients are generally perceived as healthy individuals with a benign condition. However, the condition has been associated with increased cardiovascular mortality and changes in autonomic nervous system activity. This study aimed to investigate whether pRP is associated with pervasive changes in autonomic nervous activity. The hypothesis was that patients with pRP have increased sympathetic nervous activity. Methods: The autonomic nervous activity of 22 patients with pRP was investigated by means of heart rate variability (HRV) and the plasma catecholamine response to head-up tilt and compared with 22 age- and gender-matched controls. In addition, the patients were examined with a [123I]metaiodobenzylguanidine heart scintigraphy and compared with an external control group. Results: The plasma norepinephrine response to head-up tilt was significantly lower in the patient group than in the control group. Similarly, the heart scintigraphy revealed a lower heart-to-mediastinum ratio in the patient group than in the control group. HRV analysis did not reveal significant differences between the groups. Conclusion: The findings of the study showed that the autonomic nervous activity of patients with pRP was altered compared with the activity of healthy individuals. This was observed both during rest and after positional stress, but the findings did not uniformly concur with our initial hypothesis.",
keywords = "neurophysiology, parasympathetic nervous system, plasma epinephrine, plasma norepinephrine, sympathetic nervous system, [I] metaiodobenzylguanidine",
author = "Lotte Lindberg and Brinth, {Louise S.} and Bergmann, {Marianne L.} and Bent Kristensen and Hansen, {Tine W.} and Philip Hasbak and Thomsen, {Jane F.} and Ebbe Eldrup and Jensen, {Lars T.}",
note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine.",
year = "2022",
doi = "10.1111/cpf.12737",
language = "English",
volume = "42",
pages = "104--113",
journal = "Clinical Physiology and Functional Imaging",
issn = "1475-0961",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Autonomic nervous system activity in primary Raynaud's phenomenon

T2 - Heart rate variability, plasma catecholamines and [123I]MIBG heart scintigraphy

AU - Lindberg, Lotte

AU - Brinth, Louise S.

AU - Bergmann, Marianne L.

AU - Kristensen, Bent

AU - Hansen, Tine W.

AU - Hasbak, Philip

AU - Thomsen, Jane F.

AU - Eldrup, Ebbe

AU - Jensen, Lars T.

N1 - Publisher Copyright: © 2021 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine.

PY - 2022

Y1 - 2022

N2 - Background and Aim: Primary Raynaud's phenomenon (pRP) is characterized by an exaggerated response to cold, resulting in the whitening typically of the fingers and toes. The patients are generally perceived as healthy individuals with a benign condition. However, the condition has been associated with increased cardiovascular mortality and changes in autonomic nervous system activity. This study aimed to investigate whether pRP is associated with pervasive changes in autonomic nervous activity. The hypothesis was that patients with pRP have increased sympathetic nervous activity. Methods: The autonomic nervous activity of 22 patients with pRP was investigated by means of heart rate variability (HRV) and the plasma catecholamine response to head-up tilt and compared with 22 age- and gender-matched controls. In addition, the patients were examined with a [123I]metaiodobenzylguanidine heart scintigraphy and compared with an external control group. Results: The plasma norepinephrine response to head-up tilt was significantly lower in the patient group than in the control group. Similarly, the heart scintigraphy revealed a lower heart-to-mediastinum ratio in the patient group than in the control group. HRV analysis did not reveal significant differences between the groups. Conclusion: The findings of the study showed that the autonomic nervous activity of patients with pRP was altered compared with the activity of healthy individuals. This was observed both during rest and after positional stress, but the findings did not uniformly concur with our initial hypothesis.

AB - Background and Aim: Primary Raynaud's phenomenon (pRP) is characterized by an exaggerated response to cold, resulting in the whitening typically of the fingers and toes. The patients are generally perceived as healthy individuals with a benign condition. However, the condition has been associated with increased cardiovascular mortality and changes in autonomic nervous system activity. This study aimed to investigate whether pRP is associated with pervasive changes in autonomic nervous activity. The hypothesis was that patients with pRP have increased sympathetic nervous activity. Methods: The autonomic nervous activity of 22 patients with pRP was investigated by means of heart rate variability (HRV) and the plasma catecholamine response to head-up tilt and compared with 22 age- and gender-matched controls. In addition, the patients were examined with a [123I]metaiodobenzylguanidine heart scintigraphy and compared with an external control group. Results: The plasma norepinephrine response to head-up tilt was significantly lower in the patient group than in the control group. Similarly, the heart scintigraphy revealed a lower heart-to-mediastinum ratio in the patient group than in the control group. HRV analysis did not reveal significant differences between the groups. Conclusion: The findings of the study showed that the autonomic nervous activity of patients with pRP was altered compared with the activity of healthy individuals. This was observed both during rest and after positional stress, but the findings did not uniformly concur with our initial hypothesis.

KW - neurophysiology

KW - parasympathetic nervous system

KW - plasma epinephrine

KW - plasma norepinephrine

KW - sympathetic nervous system

KW - [I] metaiodobenzylguanidine

U2 - 10.1111/cpf.12737

DO - 10.1111/cpf.12737

M3 - Journal article

C2 - 34972251

AN - SCOPUS:85122517398

VL - 42

SP - 104

EP - 113

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

SN - 1475-0961

IS - 2

ER -

ID: 314073709