TY - JOUR

T1 - Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

AU - Zamora-Ros, Raul

AU - Lujan-Barroso, Leila

AU - Achaintre, David

AU - Franceschi, Silvia

AU - Kyro, Cecilie

AU - Overvad, Kim

AU - Tjonneland, Anne

AU - Truong, Therese

AU - Lecuyer, Lucie

AU - Boutron-Ruault, Marie-Christine

AU - Katzke, Verena

AU - Johnson, Theron S.

AU - Schulze, Matthias B.

AU - Trichopoulou, Antonia

AU - Peppa, Eleni

AU - La Vechia, Carlo

AU - Masala, Giovanna

AU - Pala, Valeria

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Ricceri, Fulvio

AU - Skeie, Guri

AU - Quiros, J. Ramon

AU - Rodriguez-Barranco, Miguel

AU - Amiano, Pilar

AU - Chirlaque, Maria-Dolores

AU - Ardanaz, Eva

AU - Almquist, Martin

AU - Hennings, Joakim

AU - Vermeulen, Roel

AU - Wareham, Nicholas J.

AU - Tong, Tammy Y. N.

AU - Aune, Dagfinn

AU - Byrnes, Graham

AU - Weiderpass, Elisabete

AU - Scalbert, Augustin

AU - Rinaldi, Sabina

AU - Agudo, Antonio

PY - 2021

Y1 - 2021

N2 - Background: Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking.Objectives: The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC (the European Prospective Investigation into Cancer and Nutrition).Methods: A nested case-control study was conducted on 273 female cases (210 papillary, 45 follicular, and 18 not otherwise specified TC tumors) and 512 strictly matched controls. Blood polyphenol concentrations were analyzed by HPLC coupled to tandem MS after enzymatic hydrolysis.Results: Using multivariable-adjusted conditional logistic regression models, caffeic acid (ORlog2: 0.55; 95% CI: 0.33, 0.93) and its dehydrogenated metabolite, 3,4-dihydroxyphenylpropionic acid (ORlog2: 0.84; 95% CI: 0.71, 0.99), were inversely associated with differentiated TC risk. Similar results were observed for papillary TC, but not for follicular TC. Ferulic acid was also inversely associated only with papillary TC (ORlog2: 0.68; 95% CI: 0.51, 0.91). However, none of these relations was significant after Bonferroni correction for multiple testing. No association was observed for any of the remaining polyphenols with total differentiated, papillary, or follicular TC.Conclusions: Blood polyphenol concentrations were mostly not associated with differentiated TC risk in women, although our study raises the possibility that high blood concentrations of caffeic, 3,4-dihydroxyphenylpropionic, and ferulic acids may be related to a lower papillary TC risk.

AB - Background: Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking.Objectives: The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC (the European Prospective Investigation into Cancer and Nutrition).Methods: A nested case-control study was conducted on 273 female cases (210 papillary, 45 follicular, and 18 not otherwise specified TC tumors) and 512 strictly matched controls. Blood polyphenol concentrations were analyzed by HPLC coupled to tandem MS after enzymatic hydrolysis.Results: Using multivariable-adjusted conditional logistic regression models, caffeic acid (ORlog2: 0.55; 95% CI: 0.33, 0.93) and its dehydrogenated metabolite, 3,4-dihydroxyphenylpropionic acid (ORlog2: 0.84; 95% CI: 0.71, 0.99), were inversely associated with differentiated TC risk. Similar results were observed for papillary TC, but not for follicular TC. Ferulic acid was also inversely associated only with papillary TC (ORlog2: 0.68; 95% CI: 0.51, 0.91). However, none of these relations was significant after Bonferroni correction for multiple testing. No association was observed for any of the remaining polyphenols with total differentiated, papillary, or follicular TC.Conclusions: Blood polyphenol concentrations were mostly not associated with differentiated TC risk in women, although our study raises the possibility that high blood concentrations of caffeic, 3,4-dihydroxyphenylpropionic, and ferulic acids may be related to a lower papillary TC risk.

KW - polyphenol

KW - biomarkers

KW - thyroid cancer

KW - EPIC

KW - nested case-control study

KW - URINARY-EXCRETION

KW - FERULIC ACID

KW - RISK

KW - METABOLITES

KW - BIOMARKERS

KW - MARKERS

KW - DIET

U2 - 10.1093/ajcn/nqaa277

DO - 10.1093/ajcn/nqaa277

M3 - Journal article

C2 - 33021645

VL - 113

SP - 162

EP - 171

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 1

ER -