BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis
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BMI in relation to sperm count : an updated systematic review and collaborative meta-analysis. / Sermondade, N; Faure, C; Fezeu, L; Shayeb, A G; Bonde, J P; Jensen, T K; Van Wely, M; Cao, J; Martini, A C; Eskandar, M; Chavarro, J E; Koloszar, S; Twigt, J M; Ramlau-Hansen, C H; Borges, E; Lotti, F; Steegers-Theunissen, R P M; Zorn, B; Polotsky, A J; La Vignera, S; Eskenazi, B; Tremellen, K; Magnusdottir, E V; Fejes, I; Hercberg, S; Lévy, R; Czernichow, S.
In: Human Reproduction Update, Vol. 19, No. 3, 2013, p. 221-231.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - BMI in relation to sperm count
T2 - an updated systematic review and collaborative meta-analysis
AU - Sermondade, N
AU - Faure, C
AU - Fezeu, L
AU - Shayeb, A G
AU - Bonde, J P
AU - Jensen, T K
AU - Van Wely, M
AU - Cao, J
AU - Martini, A C
AU - Eskandar, M
AU - Chavarro, J E
AU - Koloszar, S
AU - Twigt, J M
AU - Ramlau-Hansen, C H
AU - Borges, E
AU - Lotti, F
AU - Steegers-Theunissen, R P M
AU - Zorn, B
AU - Polotsky, A J
AU - La Vignera, S
AU - Eskenazi, B
AU - Tremellen, K
AU - Magnusdottir, E V
AU - Fejes, I
AU - Hercberg, S
AU - Lévy, R
AU - Czernichow, S
PY - 2013
Y1 - 2013
N2 - BACKGROUND The global obesity epidemic has paralleled a decrease in semen quality. Yet, the association between obesity and sperm parameters remains controversial. The purpose of this report was to update the evidence on the association between BMI and sperm count through a systematic review with meta-analysis. METHODS A systematic review of available literature (with no language restriction) was performed to investigate the impact of BMI on sperm count. Relevant studies published until June 2012 were identified from a Pubmed and EMBASE search. We also included unpublished data (n = 717 men) obtained from the Infertility Center of Bondy, France. Abstracts of relevant articles were examined and studies that could be included in this review were retrieved. Authors of relevant studies for the meta-analysis were contacted by email and asked to provide standardized data. RESULTS A total of 21 studies were included in the meta-analysis, resulting in a sample of 13 077 men from the general population and attending fertility clinics. Data were stratified according to the total sperm count as normozoospermia, oligozoospermia and azoospermia. Standardized weighted mean differences in sperm concentration did not differ significantly across BMI categories. There was a J-shaped relationship between BMI categories and risk of oligozoospermia or azoospermia. Compared with men of normal weight, the odds ratio (95% confidence interval) for oligozoospermia or azoospermia was 1.15 (0.93-1.43) for underweight, 1.11 (1.01-1.21) for overweight, 1.28 (1.06-1.55) for obese and 2.04 (1.59-2.62) for morbidly obese men. CONCLUSIONS Overweight and obesity were associated with an increased prevalence of azoospermia or oligozoospermia. The main limitation of this report is that studied populations varied, with men recruited from both the general population and infertile couples. Whether weight normalization could improve sperm parameters should be evaluated further.
AB - BACKGROUND The global obesity epidemic has paralleled a decrease in semen quality. Yet, the association between obesity and sperm parameters remains controversial. The purpose of this report was to update the evidence on the association between BMI and sperm count through a systematic review with meta-analysis. METHODS A systematic review of available literature (with no language restriction) was performed to investigate the impact of BMI on sperm count. Relevant studies published until June 2012 were identified from a Pubmed and EMBASE search. We also included unpublished data (n = 717 men) obtained from the Infertility Center of Bondy, France. Abstracts of relevant articles were examined and studies that could be included in this review were retrieved. Authors of relevant studies for the meta-analysis were contacted by email and asked to provide standardized data. RESULTS A total of 21 studies were included in the meta-analysis, resulting in a sample of 13 077 men from the general population and attending fertility clinics. Data were stratified according to the total sperm count as normozoospermia, oligozoospermia and azoospermia. Standardized weighted mean differences in sperm concentration did not differ significantly across BMI categories. There was a J-shaped relationship between BMI categories and risk of oligozoospermia or azoospermia. Compared with men of normal weight, the odds ratio (95% confidence interval) for oligozoospermia or azoospermia was 1.15 (0.93-1.43) for underweight, 1.11 (1.01-1.21) for overweight, 1.28 (1.06-1.55) for obese and 2.04 (1.59-2.62) for morbidly obese men. CONCLUSIONS Overweight and obesity were associated with an increased prevalence of azoospermia or oligozoospermia. The main limitation of this report is that studied populations varied, with men recruited from both the general population and infertile couples. Whether weight normalization could improve sperm parameters should be evaluated further.
KW - Azoospermia
KW - Body Mass Index
KW - Body Weight
KW - Fertility
KW - France
KW - Humans
KW - Male
KW - Obesity
KW - Odds Ratio
KW - Oligospermia
KW - Overweight
KW - Semen Analysis
KW - Sperm Count
KW - Spermatozoa
U2 - 10.1093/humupd/dms050
DO - 10.1093/humupd/dms050
M3 - Journal article
C2 - 23242914
VL - 19
SP - 221
EP - 231
JO - Human Reproduction Update
JF - Human Reproduction Update
SN - 1355-4786
IS - 3
ER -
ID: 138416365