Body height in young adult men and risk of dementia later in adult life

Research output: Contribution to journalJournal articleResearchpeer-review

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Body height in young adult men and risk of dementia later in adult life. / Jørgensen, Terese Sara Høj; Okholm, Gunhild Tidemann; Christensen, Kaare; Sørensen, Thorkild Ia; Osler, Merere.

In: eLife, Vol. 9, e51168, 2020.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jørgensen, TSH, Okholm, GT, Christensen, K, Sørensen, TI & Osler, M 2020, 'Body height in young adult men and risk of dementia later in adult life', eLife, vol. 9, e51168. https://doi.org/10.7554/eLife.51168

APA

Jørgensen, T. S. H., Okholm, G. T., Christensen, K., Sørensen, T. I., & Osler, M. (2020). Body height in young adult men and risk of dementia later in adult life. eLife, 9, [e51168]. https://doi.org/10.7554/eLife.51168

Vancouver

Jørgensen TSH, Okholm GT, Christensen K, Sørensen TI, Osler M. Body height in young adult men and risk of dementia later in adult life. eLife. 2020;9. e51168. https://doi.org/10.7554/eLife.51168

Author

Jørgensen, Terese Sara Høj ; Okholm, Gunhild Tidemann ; Christensen, Kaare ; Sørensen, Thorkild Ia ; Osler, Merere. / Body height in young adult men and risk of dementia later in adult life. In: eLife. 2020 ; Vol. 9.

Bibtex

@article{0c39db2afd7e4bb5b2fdc744dc406119,
title = "Body height in young adult men and risk of dementia later in adult life",
abstract = "This study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939-1959 and examined at the conscript board were followed in Danish nationwide registers (1969-2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyses were conducted to explore the role of shared familial factors including partly shared genetics. In total, 10,599 men were diagnosed with dementia. The association between one z-score difference in body height and dementia (HR: 0.90, 95{\%} CI: 0.89;0.90) was inverse and weakened slightly after adjustment for intelligence test scores and educational level. The associations persisted in within-brother analysis and revealed a stronger, but less precise, point estimate than the cohort analysis of brothers. The twin analysis showed similar, but imprecise estimates.",
author = "J{\o}rgensen, {Terese Sara H{\o}j} and Okholm, {Gunhild Tidemann} and Kaare Christensen and S{\o}rensen, {Thorkild Ia} and Merere Osler",
note = "{\circledC} 2020, J{\o}rgensen et al.",
year = "2020",
doi = "10.7554/eLife.51168",
language = "English",
volume = "9",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications Ltd.",

}

RIS

TY - JOUR

T1 - Body height in young adult men and risk of dementia later in adult life

AU - Jørgensen, Terese Sara Høj

AU - Okholm, Gunhild Tidemann

AU - Christensen, Kaare

AU - Sørensen, Thorkild Ia

AU - Osler, Merere

N1 - © 2020, Jørgensen et al.

PY - 2020

Y1 - 2020

N2 - This study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939-1959 and examined at the conscript board were followed in Danish nationwide registers (1969-2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyses were conducted to explore the role of shared familial factors including partly shared genetics. In total, 10,599 men were diagnosed with dementia. The association between one z-score difference in body height and dementia (HR: 0.90, 95% CI: 0.89;0.90) was inverse and weakened slightly after adjustment for intelligence test scores and educational level. The associations persisted in within-brother analysis and revealed a stronger, but less precise, point estimate than the cohort analysis of brothers. The twin analysis showed similar, but imprecise estimates.

AB - This study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939-1959 and examined at the conscript board were followed in Danish nationwide registers (1969-2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyses were conducted to explore the role of shared familial factors including partly shared genetics. In total, 10,599 men were diagnosed with dementia. The association between one z-score difference in body height and dementia (HR: 0.90, 95% CI: 0.89;0.90) was inverse and weakened slightly after adjustment for intelligence test scores and educational level. The associations persisted in within-brother analysis and revealed a stronger, but less precise, point estimate than the cohort analysis of brothers. The twin analysis showed similar, but imprecise estimates.

U2 - 10.7554/eLife.51168

DO - 10.7554/eLife.51168

M3 - Journal article

C2 - 32041683

VL - 9

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e51168

ER -

ID: 235963232