Chronic hyperglycemia, hypercholesterolemia, and metabolic syndrome are associated with risk of tendon injury
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Chronic hyperglycemia, hypercholesterolemia, and metabolic syndrome are associated with risk of tendon injury. / Skovgaard, Dorthe; Siersma, Volkert D.; Klausen, Soren Bering; Visnes, Havard; Haukenes, Inger; Bang, Christine W.; Bager, Peter; Gravare Silbernagel, Karin; Gaida, Jamie; Magnusson, Stig Peter; Kjaer, Michael; Couppe, Christian.
In: Scandinavian Journal of Medicine & Science in Sports, Vol. 31, No. 9, 2021, p. 1822-1831.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Chronic hyperglycemia, hypercholesterolemia, and metabolic syndrome are associated with risk of tendon injury
AU - Skovgaard, Dorthe
AU - Siersma, Volkert D.
AU - Klausen, Soren Bering
AU - Visnes, Havard
AU - Haukenes, Inger
AU - Bang, Christine W.
AU - Bager, Peter
AU - Gravare Silbernagel, Karin
AU - Gaida, Jamie
AU - Magnusson, Stig Peter
AU - Kjaer, Michael
AU - Couppe, Christian
PY - 2021
Y1 - 2021
N2 - Tendon injury is a considerable problem affecting both physically active and sedentary people. The aim of this study was to examine the relationship between markers for metabolic disorders (hyperglycemia, hypercholesterolemia, and metabolic syndrome) and the risk of developing tendon injuries requiring referral to a hospital. The Copenhagen City Heart Study is a prospective study of diabetic and non-diabetic individuals from the Danish general population with different physical activity levels. The cohort was followed for 3 years via national registers with respect to tendon injuries. Data from 5856 individuals (median age 62 years) were included. The overall incidence of tendon injury in both upper and lower extremities that required an outpatient or in-house visit to a hospital was similar to 5.7/1000 person years. Individuals with elevated HbA1c (glycated hemoglobin) even in the prediabetic range (HbA1c>5.7%) had a similar to 3 times higher risk of tendon injury in the lower extremities only, as compared to individuals with normal HbA1C levels. Hypercholesterolemia (total cholesterol>5 mmol/L) increased risk of tendon injury in the upper extremities by similar to 1.5 times, and individuals with metabolic syndrome had similar to 2.5 times higher risk of tendon injury in both upper and lower extremities. In conclusion, these data demonstrate for the first time in a large cohort with different physical activity levels that the indicators for metabolic syndrome are a powerful systemic determinant of tendon injury, and two of its components, hyperglycemia and hypercholesterolemia, each independently make tendons susceptible for damage and injury.
AB - Tendon injury is a considerable problem affecting both physically active and sedentary people. The aim of this study was to examine the relationship between markers for metabolic disorders (hyperglycemia, hypercholesterolemia, and metabolic syndrome) and the risk of developing tendon injuries requiring referral to a hospital. The Copenhagen City Heart Study is a prospective study of diabetic and non-diabetic individuals from the Danish general population with different physical activity levels. The cohort was followed for 3 years via national registers with respect to tendon injuries. Data from 5856 individuals (median age 62 years) were included. The overall incidence of tendon injury in both upper and lower extremities that required an outpatient or in-house visit to a hospital was similar to 5.7/1000 person years. Individuals with elevated HbA1c (glycated hemoglobin) even in the prediabetic range (HbA1c>5.7%) had a similar to 3 times higher risk of tendon injury in the lower extremities only, as compared to individuals with normal HbA1C levels. Hypercholesterolemia (total cholesterol>5 mmol/L) increased risk of tendon injury in the upper extremities by similar to 1.5 times, and individuals with metabolic syndrome had similar to 2.5 times higher risk of tendon injury in both upper and lower extremities. In conclusion, these data demonstrate for the first time in a large cohort with different physical activity levels that the indicators for metabolic syndrome are a powerful systemic determinant of tendon injury, and two of its components, hyperglycemia and hypercholesterolemia, each independently make tendons susceptible for damage and injury.
KW - HbA1C
KW - hypercholesterolemia
KW - hyperglycemia
KW - metabolic syndrome
KW - tendinopathy
KW - tendon rupture
KW - ACHILLES-TENDON
KW - DIABETES-MELLITUS
KW - BODY-COMPOSITION
KW - PATELLAR TENDON
KW - JUMPERS KNEE
KW - TENDINOPATHY
KW - ADIPOSITY
KW - RUPTURE
KW - EPICONDYLITIS
KW - ACCUMULATION
U2 - 10.1111/sms.13984
DO - 10.1111/sms.13984
M3 - Journal article
C2 - 33963621
VL - 31
SP - 1822
EP - 1831
JO - Scandinavian Journal of Medicine & Science in Sports
JF - Scandinavian Journal of Medicine & Science in Sports
SN - 0905-7188
IS - 9
ER -
ID: 271868938