Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

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Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts. / Rothwell, Joseph A.; Bešević, Jelena; Dimou, Niki; Breeur, Marie; Murphy, Neil; Jenab, Mazda; Wedekind, Roland; Viallon, Vivian; Ferrari, Pietro; Achaintre, David; Gicquiau, Audrey; Rinaldi, Sabina; Scalbert, Augustin; Huybrechts, Inge; Prehn, Cornelia; Adamski, Jerzy; Cross, Amanda J.; Keun, Hector; Chadeau-Hyam, Marc; Boutron-Ruault, Marie Christine; Overvad, Kim; Dahm, Christina C.; Nøst, Therese Haugdahl; Sandanger, Torkjel M.; Skeie, Guri; Zamora-Ros, Raul; Tsilidis, Kostas K.; Eichelmann, Fabian; Schulze, Matthias B.; van Guelpen, Bethany; Vidman, Linda; Sánchez, Maria José; Amiano, Pilar; Ardanaz, Eva; Smith-Byrne, Karl; Travis, Ruth; Katzke, Verena; Kaaks, Rudolf; Derksen, Jeroen W.G.; Colorado-Yohar, Sandra; Tumino, Rosario; Bueno-de-Mesquita, Bas; Vineis, Paolo; Palli, Domenico; Pasanisi, Fabrizio; Eriksen, Anne Kirstine; Tjønneland, Anne; Severi, Gianluca; Gunter, Marc J.

In: BMC Medicine, Vol. 21, No. 1, 80, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rothwell, JA, Bešević, J, Dimou, N, Breeur, M, Murphy, N, Jenab, M, Wedekind, R, Viallon, V, Ferrari, P, Achaintre, D, Gicquiau, A, Rinaldi, S, Scalbert, A, Huybrechts, I, Prehn, C, Adamski, J, Cross, AJ, Keun, H, Chadeau-Hyam, M, Boutron-Ruault, MC, Overvad, K, Dahm, CC, Nøst, TH, Sandanger, TM, Skeie, G, Zamora-Ros, R, Tsilidis, KK, Eichelmann, F, Schulze, MB, van Guelpen, B, Vidman, L, Sánchez, MJ, Amiano, P, Ardanaz, E, Smith-Byrne, K, Travis, R, Katzke, V, Kaaks, R, Derksen, JWG, Colorado-Yohar, S, Tumino, R, Bueno-de-Mesquita, B, Vineis, P, Palli, D, Pasanisi, F, Eriksen, AK, Tjønneland, A, Severi, G & Gunter, MJ 2023, 'Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts', BMC Medicine, vol. 21, no. 1, 80. https://doi.org/10.1186/s12916-023-02739-4

APA

Rothwell, J. A., Bešević, J., Dimou, N., Breeur, M., Murphy, N., Jenab, M., Wedekind, R., Viallon, V., Ferrari, P., Achaintre, D., Gicquiau, A., Rinaldi, S., Scalbert, A., Huybrechts, I., Prehn, C., Adamski, J., Cross, A. J., Keun, H., Chadeau-Hyam, M., ... Gunter, M. J. (2023). Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts. BMC Medicine, 21(1), [80]. https://doi.org/10.1186/s12916-023-02739-4

Vancouver

Rothwell JA, Bešević J, Dimou N, Breeur M, Murphy N, Jenab M et al. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts. BMC Medicine. 2023;21(1). 80. https://doi.org/10.1186/s12916-023-02739-4

Author

Rothwell, Joseph A. ; Bešević, Jelena ; Dimou, Niki ; Breeur, Marie ; Murphy, Neil ; Jenab, Mazda ; Wedekind, Roland ; Viallon, Vivian ; Ferrari, Pietro ; Achaintre, David ; Gicquiau, Audrey ; Rinaldi, Sabina ; Scalbert, Augustin ; Huybrechts, Inge ; Prehn, Cornelia ; Adamski, Jerzy ; Cross, Amanda J. ; Keun, Hector ; Chadeau-Hyam, Marc ; Boutron-Ruault, Marie Christine ; Overvad, Kim ; Dahm, Christina C. ; Nøst, Therese Haugdahl ; Sandanger, Torkjel M. ; Skeie, Guri ; Zamora-Ros, Raul ; Tsilidis, Kostas K. ; Eichelmann, Fabian ; Schulze, Matthias B. ; van Guelpen, Bethany ; Vidman, Linda ; Sánchez, Maria José ; Amiano, Pilar ; Ardanaz, Eva ; Smith-Byrne, Karl ; Travis, Ruth ; Katzke, Verena ; Kaaks, Rudolf ; Derksen, Jeroen W.G. ; Colorado-Yohar, Sandra ; Tumino, Rosario ; Bueno-de-Mesquita, Bas ; Vineis, Paolo ; Palli, Domenico ; Pasanisi, Fabrizio ; Eriksen, Anne Kirstine ; Tjønneland, Anne ; Severi, Gianluca ; Gunter, Marc J. / Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts. In: BMC Medicine. 2023 ; Vol. 21, No. 1.

Bibtex

@article{13fb37d70b694896a973af595f3e184d,
title = "Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts",
abstract = "Background: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts. Methods: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases. Results: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69–0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87–0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75–0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89–1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded. Conclusions: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.",
keywords = "Amino acids, Colorectal cancer, Glutamine, Histidine",
author = "Rothwell, {Joseph A.} and Jelena Be{\v s}evi{\'c} and Niki Dimou and Marie Breeur and Neil Murphy and Mazda Jenab and Roland Wedekind and Vivian Viallon and Pietro Ferrari and David Achaintre and Audrey Gicquiau and Sabina Rinaldi and Augustin Scalbert and Inge Huybrechts and Cornelia Prehn and Jerzy Adamski and Cross, {Amanda J.} and Hector Keun and Marc Chadeau-Hyam and Boutron-Ruault, {Marie Christine} and Kim Overvad and Dahm, {Christina C.} and N{\o}st, {Therese Haugdahl} and Sandanger, {Torkjel M.} and Guri Skeie and Raul Zamora-Ros and Tsilidis, {Kostas K.} and Fabian Eichelmann and Schulze, {Matthias B.} and {van Guelpen}, Bethany and Linda Vidman and S{\'a}nchez, {Maria Jos{\'e}} and Pilar Amiano and Eva Ardanaz and Karl Smith-Byrne and Ruth Travis and Verena Katzke and Rudolf Kaaks and Derksen, {Jeroen W.G.} and Sandra Colorado-Yohar and Rosario Tumino and Bas Bueno-de-Mesquita and Paolo Vineis and Domenico Palli and Fabrizio Pasanisi and Eriksen, {Anne Kirstine} and Anne Tj{\o}nneland and Gianluca Severi and Gunter, {Marc J.}",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
doi = "10.1186/s12916-023-02739-4",
language = "English",
volume = "21",
journal = "BMC Medicine",
issn = "1741-7015",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

AU - Rothwell, Joseph A.

AU - Bešević, Jelena

AU - Dimou, Niki

AU - Breeur, Marie

AU - Murphy, Neil

AU - Jenab, Mazda

AU - Wedekind, Roland

AU - Viallon, Vivian

AU - Ferrari, Pietro

AU - Achaintre, David

AU - Gicquiau, Audrey

AU - Rinaldi, Sabina

AU - Scalbert, Augustin

AU - Huybrechts, Inge

AU - Prehn, Cornelia

AU - Adamski, Jerzy

AU - Cross, Amanda J.

AU - Keun, Hector

AU - Chadeau-Hyam, Marc

AU - Boutron-Ruault, Marie Christine

AU - Overvad, Kim

AU - Dahm, Christina C.

AU - Nøst, Therese Haugdahl

AU - Sandanger, Torkjel M.

AU - Skeie, Guri

AU - Zamora-Ros, Raul

AU - Tsilidis, Kostas K.

AU - Eichelmann, Fabian

AU - Schulze, Matthias B.

AU - van Guelpen, Bethany

AU - Vidman, Linda

AU - Sánchez, Maria José

AU - Amiano, Pilar

AU - Ardanaz, Eva

AU - Smith-Byrne, Karl

AU - Travis, Ruth

AU - Katzke, Verena

AU - Kaaks, Rudolf

AU - Derksen, Jeroen W.G.

AU - Colorado-Yohar, Sandra

AU - Tumino, Rosario

AU - Bueno-de-Mesquita, Bas

AU - Vineis, Paolo

AU - Palli, Domenico

AU - Pasanisi, Fabrizio

AU - Eriksen, Anne Kirstine

AU - Tjønneland, Anne

AU - Severi, Gianluca

AU - Gunter, Marc J.

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2023

Y1 - 2023

N2 - Background: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts. Methods: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases. Results: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69–0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87–0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75–0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89–1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded. Conclusions: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.

AB - Background: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts. Methods: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases. Results: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69–0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87–0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75–0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89–1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded. Conclusions: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.

KW - Amino acids

KW - Colorectal cancer

KW - Glutamine

KW - Histidine

U2 - 10.1186/s12916-023-02739-4

DO - 10.1186/s12916-023-02739-4

M3 - Journal article

C2 - 36855092

AN - SCOPUS:85149153333

VL - 21

JO - BMC Medicine

JF - BMC Medicine

SN - 1741-7015

IS - 1

M1 - 80

ER -

ID: 340060215