Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women
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Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women. / Rinaldi, Sabina; Dossus, Laure; Keski-Rahkonen, Pekka; Kiss, Agneta; Navionis, Anne-Sophie; Biessy, Carine; Travis, Ruth; Weiderpass, Elisabete; Romieu, Isabelle; Eriksen, Anne Kirstine; Tjonneland, Anne; Kvaskoff, Marina; Canonico, Marianne; Truong, Thérèse; Katzke, Verena; Kaaks, Rudolf; Catalano, Alberto; Panico, Salvatore; Masala, Giovanna; Tumino, Rosario; Lukic, Marko; Olsen, Karina Standahl; Zamora-Ros, Raul; Santiuste, Carmen; Aizpurua Atxega, Amaia; Guevara, Marcela; Rodriguez-Barranco, Miguel; Sandstrom, Maria; Hennings, Joakim; Almquist, Martin; Aglago Kouassivi, Elom; Christakoudi, Sofia; Gunter, Marc; Franceschi, Silvia.
In: International Journal of Cancer, Vol. 154, No. 12, 2024, p. 2064-2074.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women
AU - Rinaldi, Sabina
AU - Dossus, Laure
AU - Keski-Rahkonen, Pekka
AU - Kiss, Agneta
AU - Navionis, Anne-Sophie
AU - Biessy, Carine
AU - Travis, Ruth
AU - Weiderpass, Elisabete
AU - Romieu, Isabelle
AU - Eriksen, Anne Kirstine
AU - Tjonneland, Anne
AU - Kvaskoff, Marina
AU - Canonico, Marianne
AU - Truong, Thérèse
AU - Katzke, Verena
AU - Kaaks, Rudolf
AU - Catalano, Alberto
AU - Panico, Salvatore
AU - Masala, Giovanna
AU - Tumino, Rosario
AU - Lukic, Marko
AU - Olsen, Karina Standahl
AU - Zamora-Ros, Raul
AU - Santiuste, Carmen
AU - Aizpurua Atxega, Amaia
AU - Guevara, Marcela
AU - Rodriguez-Barranco, Miguel
AU - Sandstrom, Maria
AU - Hennings, Joakim
AU - Almquist, Martin
AU - Aglago Kouassivi, Elom
AU - Christakoudi, Sofia
AU - Gunter, Marc
AU - Franceschi, Silvia
N1 - © 2024 The World Health Organization. The World Health Organization retains copyright and all other rights in the manuscript of this article as submitted for publication.
PY - 2024
Y1 - 2024
N2 - Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in post-menopausal women, and 70 in men) and 706 cancer-free controls. Women taking exogenous hormones at blood donation were excluded. Plasma concentrations of testosterone, androstenedione, dehydroepiandrosterone, estradiol, estrone and progesterone (in pre-menopausal women only) were performed using liquid chromatography/mass spectrometry method. SHBG concentrations were measured by immunoassay. Odds ratios (ORs) were estimated using conditional logistic regression models adjusted for possible confounders. No significant associations were observed in men and postmenopausal women, while a borderline significant increase in differentiated TC risk was observed with increasing testosterone (adjusted OR T3 vs T1: 1.68, 95% CI: 0.96-2.92, ptrend = .06) and androstenedione concentrations in pre/perimenopausal women (adjusted OR T3 vs T1: 1.78, 95% CI: 0.96-3.30, ptrend = .06, respectively). A borderline decrease in risk was observed for the highest progesterone/estradiol ratio (adjusted OR T3 vs T1: 0.54, 95% CI: 0.28-1.05, ptrend = .07). Overall, our results do not support a major role of circulating sex steroids in the etiology of differentiated TC in post-menopausal women and men but may suggest an involvement of altered sex steroid production in pre-menopausal women.
AB - Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in post-menopausal women, and 70 in men) and 706 cancer-free controls. Women taking exogenous hormones at blood donation were excluded. Plasma concentrations of testosterone, androstenedione, dehydroepiandrosterone, estradiol, estrone and progesterone (in pre-menopausal women only) were performed using liquid chromatography/mass spectrometry method. SHBG concentrations were measured by immunoassay. Odds ratios (ORs) were estimated using conditional logistic regression models adjusted for possible confounders. No significant associations were observed in men and postmenopausal women, while a borderline significant increase in differentiated TC risk was observed with increasing testosterone (adjusted OR T3 vs T1: 1.68, 95% CI: 0.96-2.92, ptrend = .06) and androstenedione concentrations in pre/perimenopausal women (adjusted OR T3 vs T1: 1.78, 95% CI: 0.96-3.30, ptrend = .06, respectively). A borderline decrease in risk was observed for the highest progesterone/estradiol ratio (adjusted OR T3 vs T1: 0.54, 95% CI: 0.28-1.05, ptrend = .07). Overall, our results do not support a major role of circulating sex steroids in the etiology of differentiated TC in post-menopausal women and men but may suggest an involvement of altered sex steroid production in pre-menopausal women.
U2 - 10.1002/ijc.34872
DO - 10.1002/ijc.34872
M3 - Journal article
C2 - 38357914
VL - 154
SP - 2064
EP - 2074
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 12
ER -
ID: 383387526