Comparing restrictive versus liberal oxygen strategies for trauma patients-the TRAUMOX2 trial: protocol for a randomised clinical trial
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Comparing restrictive versus liberal oxygen strategies for trauma patients-the TRAUMOX2 trial : protocol for a randomised clinical trial. / Baekgaard, Josefine; Arleth, Tobias; Siersma, Volkert; Hinkelbein, Jochen; Yücetepe, Sirin; Klimek, Markus; Van Vledder, Mark G.; Van Lieshout, Esther M.M.; Mikkelsen, Søren; Zwisler, Stine Thorhauge; Andersen, Mikkel; Fenger-Eriksen, Christian; Isbye, Dan L.; Rasmussen, Lars S.; Steinmetz, Jacob.
In: BMJ Open, Vol. 12, No. 11, e064047, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Comparing restrictive versus liberal oxygen strategies for trauma patients-the TRAUMOX2 trial
T2 - protocol for a randomised clinical trial
AU - Baekgaard, Josefine
AU - Arleth, Tobias
AU - Siersma, Volkert
AU - Hinkelbein, Jochen
AU - Yücetepe, Sirin
AU - Klimek, Markus
AU - Van Vledder, Mark G.
AU - Van Lieshout, Esther M.M.
AU - Mikkelsen, Søren
AU - Zwisler, Stine Thorhauge
AU - Andersen, Mikkel
AU - Fenger-Eriksen, Christian
AU - Isbye, Dan L.
AU - Rasmussen, Lars S.
AU - Steinmetz, Jacob
N1 - Publisher Copyright: ©
PY - 2022
Y1 - 2022
N2 - Introduction Supplemental oxygen is commonly used in trauma patients, although it may lead to hyperoxaemia that has been associated with pulmonary complications and increased mortality. The primary objective of this trial, TRAUMOX2, is to compare a restrictive versus liberal oxygen strategy the first 8 hours following trauma. Methods and analysis TRAUMOX2 is an investigator-initiated, international, parallel-grouped, superiority, outcome assessor-blinded and analyst-blinded, randomised, controlled, clinical trial. Adult patients with suspected major trauma are randomised to eight hours of a restrictive or liberal oxygen strategy. The restrictive group receives the lowest dosage of oxygen (>21%) that ensures an SpO 2 of 94%. The liberal group receives 12-15 L O 2 /min or FiO 2 =0.6-1.0. The primary outcome is a composite of 30-day mortality and/or development of major respiratory complications (pneumonia and/or acute respiratory distress syndrome). With 710 participants in each arm, we will be able to detect a 33% risk reduction with a restrictive oxygen strategy if the incidence of our primary outcome is 15% in the liberal group. Ethics and dissemination TRAUMOX2 is carried out in accordance with the Helsinki II Declaration. It has been approved by the Danish Committee on Health Research Ethics for the Capital Region (H-21018062) and The Danish Medicines Agency, as well as the Dutch Medical Research Ethics Committee Erasmus MS (NL79921.078.21 and MEC-2021-0932). A website (www.traumox2.org) is available for updates and study results will be published in an international peer-reviewed scientific journal. Trial registration numbers EudraCT 2021-000556-19; NCT05146700.
AB - Introduction Supplemental oxygen is commonly used in trauma patients, although it may lead to hyperoxaemia that has been associated with pulmonary complications and increased mortality. The primary objective of this trial, TRAUMOX2, is to compare a restrictive versus liberal oxygen strategy the first 8 hours following trauma. Methods and analysis TRAUMOX2 is an investigator-initiated, international, parallel-grouped, superiority, outcome assessor-blinded and analyst-blinded, randomised, controlled, clinical trial. Adult patients with suspected major trauma are randomised to eight hours of a restrictive or liberal oxygen strategy. The restrictive group receives the lowest dosage of oxygen (>21%) that ensures an SpO 2 of 94%. The liberal group receives 12-15 L O 2 /min or FiO 2 =0.6-1.0. The primary outcome is a composite of 30-day mortality and/or development of major respiratory complications (pneumonia and/or acute respiratory distress syndrome). With 710 participants in each arm, we will be able to detect a 33% risk reduction with a restrictive oxygen strategy if the incidence of our primary outcome is 15% in the liberal group. Ethics and dissemination TRAUMOX2 is carried out in accordance with the Helsinki II Declaration. It has been approved by the Danish Committee on Health Research Ethics for the Capital Region (H-21018062) and The Danish Medicines Agency, as well as the Dutch Medical Research Ethics Committee Erasmus MS (NL79921.078.21 and MEC-2021-0932). A website (www.traumox2.org) is available for updates and study results will be published in an international peer-reviewed scientific journal. Trial registration numbers EudraCT 2021-000556-19; NCT05146700.
KW - Adult anaesthesia
KW - Adult intensive & critical care
KW - Respiratory physiology
KW - TRAUMA MANAGEMENT
U2 - 10.1136/bmjopen-2022-064047
DO - 10.1136/bmjopen-2022-064047
M3 - Journal article
C2 - 36344005
AN - SCOPUS:85141894352
VL - 12
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 11
M1 - e064047
ER -
ID: 327035604