TY - JOUR

T1 - Contribution of the ex vivo placental perfusion model in understanding transplacental immunoglobulin G transfer

AU - Sand, Kine Marita Knudsen

AU - Gruber, Michael M.

AU - Sandlie, Inger

AU - Mathiesen, Line

AU - Andersen, Jan Terje

AU - Wadsack, Christian

PY - 2022

Y1 - 2022

N2 - Introduction: The acquisition of humoral immunity in utero is essential for the fetus. The crucial protein, which is responsible for this part of immunity, is immunoglobulin-G (IgG). Immune functions of IgGs are mediated via the interaction of the crystallizable fragment (Fc) region of IgG with specific Fc gamma receptors (Fc gamma Rs). However, an atypical Fc gamma R, the neonatal Fc receptor (FcRn), is a key regulator of IgG transfer across the human placenta. During the last four decades ex vivo placental perfusion studies have contributed significantly to the study of mechanisms of IgG transfer across the multicellular placental barrier. Method: A PubMed search was conducted by using specific keywords: placenta, perfusion and IgG to review manuscripts using human placental perfusion to study the transplacental transfer of IgG. Relevant studies found in reference lists of these manuscripts were also added to the review, and references were included that supported or gave nuance to the discussion of the mechanisms of IgG kinetics in the placenta. Results and Discussion: We found twenty publications on the study of transplacental transfer of IgG using human ex vivo placental perfusion, by research groups with partly different settings. This review summarizes knowledge about placental IgG transfer, with a strong focus on the contributions from ex vivo placental perfusion studies.Superscript/Subscript Available

AB - Introduction: The acquisition of humoral immunity in utero is essential for the fetus. The crucial protein, which is responsible for this part of immunity, is immunoglobulin-G (IgG). Immune functions of IgGs are mediated via the interaction of the crystallizable fragment (Fc) region of IgG with specific Fc gamma receptors (Fc gamma Rs). However, an atypical Fc gamma R, the neonatal Fc receptor (FcRn), is a key regulator of IgG transfer across the human placenta. During the last four decades ex vivo placental perfusion studies have contributed significantly to the study of mechanisms of IgG transfer across the multicellular placental barrier. Method: A PubMed search was conducted by using specific keywords: placenta, perfusion and IgG to review manuscripts using human placental perfusion to study the transplacental transfer of IgG. Relevant studies found in reference lists of these manuscripts were also added to the review, and references were included that supported or gave nuance to the discussion of the mechanisms of IgG kinetics in the placenta. Results and Discussion: We found twenty publications on the study of transplacental transfer of IgG using human ex vivo placental perfusion, by research groups with partly different settings. This review summarizes knowledge about placental IgG transfer, with a strong focus on the contributions from ex vivo placental perfusion studies.Superscript/Subscript Available

KW - NEONATAL FC-RECEPTOR

KW - I-RELATED RECEPTOR

KW - HUMAN-IGG

KW - CRYSTAL-STRUCTURE

KW - MATERNAL IGG

KW - BASOLATERAL TRANSCYTOSIS

KW - MATERNOFETAL TRANSFER

KW - MONOCLONAL-ANTIBODY

KW - GAMMA-GLOBULIN

KW - BREAST-CANCER

U2 - 10.1016/j.placenta.2022.07.019

DO - 10.1016/j.placenta.2022.07.019

M3 - Journal article

C2 - 35981406

VL - 127

SP - 77

EP - 87

JO - Placenta

JF - Placenta

SN - 0143-4004

ER -