Decreased plasma levels of factor II + VII + X correlate with increased levels of soluble cytokine receptors in patients with malaria and meningococcal infections
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Decreased plasma levels of factor II + VII + X correlate with increased levels of soluble cytokine receptors in patients with malaria and meningococcal infections. / Bygbjerg, I C; Hansen, M B; Rønn, A M; Bendtzen, K; Jakobsen, P H.
In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 105, No. 2, 1997, p. 150-6.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Decreased plasma levels of factor II + VII + X correlate with increased levels of soluble cytokine receptors in patients with malaria and meningococcal infections
AU - Bygbjerg, I C
AU - Hansen, M B
AU - Rønn, A M
AU - Bendtzen, K
AU - Jakobsen, P H
N1 - Keywords: Acute Disease; Adolescent; Adult; Aged; Blood Coagulation Factors; Child; Factor VII; Factor X; Female; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Meningitis, Meningococcal; Middle Aged; Platelet Count; Prothrombin; Receptors, Cytokine; Sepsis; Solubility
PY - 1997
Y1 - 1997
N2 - The levels of coagulation factors II + VII + X and of blood platelets (thrombocytes) as well as of cytokines and soluble cytokine receptors were studied in the patients with malaria or meningococcal infections. The coagulation factors were decreased particularly in the meningococcal patients, while thrombocytes were lowest in the Plasmodium falciparum malaria patients. There was no correlation between factors II + VII + X and thrombocytes, but plasma levels of coagulation factors II + VII + X were found to correlate inversely with levels of soluble interleukin-2 receptor (sIL-2R) and soluble tumour necrosis factor-I (sTNF-RI) in patients with malaria and meningococcal infections. Elevated sIL-2R and sTNF-RI levels and decreased coagulation factors reverted to normal within 3-5 days after initiation of therapy in P. falciparum patients followed consecutively. Estimation of coagulation factors may be used to monitor the course of these common and potentially life-threatening infections.
AB - The levels of coagulation factors II + VII + X and of blood platelets (thrombocytes) as well as of cytokines and soluble cytokine receptors were studied in the patients with malaria or meningococcal infections. The coagulation factors were decreased particularly in the meningococcal patients, while thrombocytes were lowest in the Plasmodium falciparum malaria patients. There was no correlation between factors II + VII + X and thrombocytes, but plasma levels of coagulation factors II + VII + X were found to correlate inversely with levels of soluble interleukin-2 receptor (sIL-2R) and soluble tumour necrosis factor-I (sTNF-RI) in patients with malaria and meningococcal infections. Elevated sIL-2R and sTNF-RI levels and decreased coagulation factors reverted to normal within 3-5 days after initiation of therapy in P. falciparum patients followed consecutively. Estimation of coagulation factors may be used to monitor the course of these common and potentially life-threatening infections.
M3 - Journal article
C2 - 9113077
VL - 105
SP - 150
EP - 156
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 2
ER -
ID: 9830700