Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

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Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition. / Yammine, S. G.; Huybrechts, I.; Biessy, C.; Dossus, L.; Panico, S.; Sanchez, M. J.; Benetou, V.; Turzanski-Fortner, R.; Katzke, V.; Idahl, A.; Skeie, G.; Olsen, K. Standahl; Tjonneland, A.; Halkjaer, J.; Colorado-Yohar, S.; Heath, A. K.; Sonestedt, E.; Sartor, H.; Schulze, M. B.; Palli, D.; Crous-Bou, M.; Dorronsoro, A.; Overvad, K.; Gurrea, A. Barricarte; Severi, G.; Vermeulen, R. C. H.; Sandanger, T. M.; Travis, R. C.; Key, T.; Amiano, P.; Van Guelpen, B.; Johansson, M.; Sund, M.; Tumino, R.; Wareham, N.; Sacerdote, C.; Krogh, V.; Brennan, P.; Riboli, E.; Weiderpass, E.; Gunter, M. J.; Chajes, V.

In: BMC Cancer, Vol. 23, No. 1, 159, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Yammine, SG, Huybrechts, I, Biessy, C, Dossus, L, Panico, S, Sanchez, MJ, Benetou, V, Turzanski-Fortner, R, Katzke, V, Idahl, A, Skeie, G, Olsen, KS, Tjonneland, A, Halkjaer, J, Colorado-Yohar, S, Heath, AK, Sonestedt, E, Sartor, H, Schulze, MB, Palli, D, Crous-Bou, M, Dorronsoro, A, Overvad, K, Gurrea, AB, Severi, G, Vermeulen, RCH, Sandanger, TM, Travis, RC, Key, T, Amiano, P, Van Guelpen, B, Johansson, M, Sund, M, Tumino, R, Wareham, N, Sacerdote, C, Krogh, V, Brennan, P, Riboli, E, Weiderpass, E, Gunter, MJ & Chajes, V 2023, 'Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition', BMC Cancer, vol. 23, no. 1, 159. https://doi.org/10.1186/s12885-023-10611-0

APA

Yammine, S. G., Huybrechts, I., Biessy, C., Dossus, L., Panico, S., Sanchez, M. J., Benetou, V., Turzanski-Fortner, R., Katzke, V., Idahl, A., Skeie, G., Olsen, K. S., Tjonneland, A., Halkjaer, J., Colorado-Yohar, S., Heath, A. K., Sonestedt, E., Sartor, H., Schulze, M. B., ... Chajes, V. (2023). Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition. BMC Cancer, 23(1), [159]. https://doi.org/10.1186/s12885-023-10611-0

Vancouver

Yammine SG, Huybrechts I, Biessy C, Dossus L, Panico S, Sanchez MJ et al. Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition. BMC Cancer. 2023;23(1). 159. https://doi.org/10.1186/s12885-023-10611-0

Author

Yammine, S. G. ; Huybrechts, I. ; Biessy, C. ; Dossus, L. ; Panico, S. ; Sanchez, M. J. ; Benetou, V. ; Turzanski-Fortner, R. ; Katzke, V. ; Idahl, A. ; Skeie, G. ; Olsen, K. Standahl ; Tjonneland, A. ; Halkjaer, J. ; Colorado-Yohar, S. ; Heath, A. K. ; Sonestedt, E. ; Sartor, H. ; Schulze, M. B. ; Palli, D. ; Crous-Bou, M. ; Dorronsoro, A. ; Overvad, K. ; Gurrea, A. Barricarte ; Severi, G. ; Vermeulen, R. C. H. ; Sandanger, T. M. ; Travis, R. C. ; Key, T. ; Amiano, P. ; Van Guelpen, B. ; Johansson, M. ; Sund, M. ; Tumino, R. ; Wareham, N. ; Sacerdote, C. ; Krogh, V. ; Brennan, P. ; Riboli, E. ; Weiderpass, E. ; Gunter, M. J. ; Chajes, V. / Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition. In: BMC Cancer. 2023 ; Vol. 23, No. 1.

Bibtex

@article{bd0f5189f42446298ca7bd933256d810,
title = "Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition",
abstract = "BackgroundDiet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).MethodsThis analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.ResultsConsumption of n-6 gamma-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintile(Q5-Q1)=0.77, 95% CI = 0.64; 0.92, p(trend)=0.01, q-value = 0.15). This association was mainly driven by gamma-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 alpha-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk.ConclusionOur results suggest that higher consumption of gamma-linolenic acid and alpha-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.",
keywords = "Fatty acids, Endometrial cancer, Epidemiology, Diet, FISH CONSUMPTION, DATABASE, MARKERS, OBESITY, OMEGA-3, HEALTH",
author = "Yammine, {S. G.} and I. Huybrechts and C. Biessy and L. Dossus and S. Panico and Sanchez, {M. J.} and V. Benetou and R. Turzanski-Fortner and V. Katzke and A. Idahl and G. Skeie and Olsen, {K. Standahl} and A. Tjonneland and J. Halkjaer and S. Colorado-Yohar and Heath, {A. K.} and E. Sonestedt and H. Sartor and Schulze, {M. B.} and D. Palli and M. Crous-Bou and A. Dorronsoro and K. Overvad and Gurrea, {A. Barricarte} and G. Severi and Vermeulen, {R. C. H.} and Sandanger, {T. M.} and Travis, {R. C.} and T. Key and P. Amiano and {Van Guelpen}, B. and M. Johansson and M. Sund and R. Tumino and N. Wareham and C. Sacerdote and V. Krogh and P. Brennan and E. Riboli and E. Weiderpass and Gunter, {M. J.} and V. Chajes",
year = "2023",
doi = "10.1186/s12885-023-10611-0",
language = "English",
volume = "23",
journal = "B M C Cancer",
issn = "1471-2407",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

AU - Yammine, S. G.

AU - Huybrechts, I.

AU - Biessy, C.

AU - Dossus, L.

AU - Panico, S.

AU - Sanchez, M. J.

AU - Benetou, V.

AU - Turzanski-Fortner, R.

AU - Katzke, V.

AU - Idahl, A.

AU - Skeie, G.

AU - Olsen, K. Standahl

AU - Tjonneland, A.

AU - Halkjaer, J.

AU - Colorado-Yohar, S.

AU - Heath, A. K.

AU - Sonestedt, E.

AU - Sartor, H.

AU - Schulze, M. B.

AU - Palli, D.

AU - Crous-Bou, M.

AU - Dorronsoro, A.

AU - Overvad, K.

AU - Gurrea, A. Barricarte

AU - Severi, G.

AU - Vermeulen, R. C. H.

AU - Sandanger, T. M.

AU - Travis, R. C.

AU - Key, T.

AU - Amiano, P.

AU - Van Guelpen, B.

AU - Johansson, M.

AU - Sund, M.

AU - Tumino, R.

AU - Wareham, N.

AU - Sacerdote, C.

AU - Krogh, V.

AU - Brennan, P.

AU - Riboli, E.

AU - Weiderpass, E.

AU - Gunter, M. J.

AU - Chajes, V.

PY - 2023

Y1 - 2023

N2 - BackgroundDiet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).MethodsThis analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.ResultsConsumption of n-6 gamma-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintile(Q5-Q1)=0.77, 95% CI = 0.64; 0.92, p(trend)=0.01, q-value = 0.15). This association was mainly driven by gamma-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 alpha-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk.ConclusionOur results suggest that higher consumption of gamma-linolenic acid and alpha-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.

AB - BackgroundDiet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).MethodsThis analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.ResultsConsumption of n-6 gamma-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintile(Q5-Q1)=0.77, 95% CI = 0.64; 0.92, p(trend)=0.01, q-value = 0.15). This association was mainly driven by gamma-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 alpha-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk.ConclusionOur results suggest that higher consumption of gamma-linolenic acid and alpha-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.

KW - Fatty acids

KW - Endometrial cancer

KW - Epidemiology

KW - Diet

KW - FISH CONSUMPTION

KW - DATABASE

KW - MARKERS

KW - OBESITY

KW - OMEGA-3

KW - HEALTH

U2 - 10.1186/s12885-023-10611-0

DO - 10.1186/s12885-023-10611-0

M3 - Journal article

C2 - 36797668

VL - 23

JO - B M C Cancer

JF - B M C Cancer

SN - 1471-2407

IS - 1

M1 - 159

ER -

ID: 340060767