Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort
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Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort. / Gil-Lespinard, Mercedes; Castañeda, Jazmín; Almanza-Aguilera, Enrique; Gómez, Jesús Humberto; Tjønneland, Anne; Kyrø, Cecilie; Overvad, Kim; Katzke, Verena; Schulze, Matthias B.; Masala, Giovanna; Agnoli, Claudia; Santucci de Magistris, Maria; Tumino, Rosario; Sacerdote, Carlotta; Skeie, Guri; Lasheras, Cristina; Molina-Montes, Esther; Huerta, José María; Barricarte, Aurelio; Amiano, Pilar; Sonestedt, Emily; da Silva, Marisa; Johansson, Ingegerd; Hultdin, Johan; May, Anne M.; Forouhi, Nita G.; Heath, Alicia K.; Freisling, Heinz; Weiderpass, Elisabete; Scalbert, Augustin; Zamora-Ros, Raul.
In: Antioxidants, Vol. 11, No. 12, 2425, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort
AU - Gil-Lespinard, Mercedes
AU - Castañeda, Jazmín
AU - Almanza-Aguilera, Enrique
AU - Gómez, Jesús Humberto
AU - Tjønneland, Anne
AU - Kyrø, Cecilie
AU - Overvad, Kim
AU - Katzke, Verena
AU - Schulze, Matthias B.
AU - Masala, Giovanna
AU - Agnoli, Claudia
AU - Santucci de Magistris, Maria
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Skeie, Guri
AU - Lasheras, Cristina
AU - Molina-Montes, Esther
AU - Huerta, José María
AU - Barricarte, Aurelio
AU - Amiano, Pilar
AU - Sonestedt, Emily
AU - da Silva, Marisa
AU - Johansson, Ingegerd
AU - Hultdin, Johan
AU - May, Anne M.
AU - Forouhi, Nita G.
AU - Heath, Alicia K.
AU - Freisling, Heinz
AU - Weiderpass, Elisabete
AU - Scalbert, Augustin
AU - Zamora-Ros, Raul
N1 - Publisher Copyright: © 2022 by the authors.
PY - 2022
Y1 - 2022
N2 - Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: −0.071 (95% CI: −0.085; −0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source.
AB - Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: −0.071 (95% CI: −0.085; −0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source.
KW - body weight
KW - cohort
KW - EPIC
KW - intake
KW - obesity
KW - polyphenol
U2 - 10.3390/antiox11122425
DO - 10.3390/antiox11122425
M3 - Journal article
C2 - 36552633
AN - SCOPUS:85144944086
VL - 11
JO - Antioxidants
JF - Antioxidants
SN - 2076-3921
IS - 12
M1 - 2425
ER -
ID: 332029845