Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). / Van Puyvelde, Heleen; Papadimitriou, Nikos; Clasen, Joanna; Muller, David; Biessy, Carine; Ferrari, Pietro; Halkjær, Jytte; Overvad, Kim; Tjønneland, Anne; Fortner, Renee T.; Katzke, Verena; Schulze, Matthias B.; Chiodini, Paolo; Masala, Giovanna; Pala, Valeria; Sacerdote, Carlotta; Tumino, Rosario; Bakker, Marije F.; Agudo, Antonio; Ardanaz, Eva; Chirlaque Lopez, Maria Dolores; Sanchez, Maria-Jose; Ericson, Ulrika; Gylling, Bjorn; Karlsson, Therese; Manjer, Jonas; Schmidt, Julie A.; Nicolas, Genevieve; Casagrande, Corinne; Weiderpass, Elisabete; Heath, Alicia K.; Godderis, Lode; Van Herck, Koen; De Bacquer, Dirk; Gunter, Marc J.; Huybrechts, Inge.
In: Nutrients, Vol. 13, No. 6, 1843, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
AU - Van Puyvelde, Heleen
AU - Papadimitriou, Nikos
AU - Clasen, Joanna
AU - Muller, David
AU - Biessy, Carine
AU - Ferrari, Pietro
AU - Halkjær, Jytte
AU - Overvad, Kim
AU - Tjønneland, Anne
AU - Fortner, Renee T.
AU - Katzke, Verena
AU - Schulze, Matthias B.
AU - Chiodini, Paolo
AU - Masala, Giovanna
AU - Pala, Valeria
AU - Sacerdote, Carlotta
AU - Tumino, Rosario
AU - Bakker, Marije F.
AU - Agudo, Antonio
AU - Ardanaz, Eva
AU - Chirlaque Lopez, Maria Dolores
AU - Sanchez, Maria-Jose
AU - Ericson, Ulrika
AU - Gylling, Bjorn
AU - Karlsson, Therese
AU - Manjer, Jonas
AU - Schmidt, Julie A.
AU - Nicolas, Genevieve
AU - Casagrande, Corinne
AU - Weiderpass, Elisabete
AU - Heath, Alicia K.
AU - Godderis, Lode
AU - Van Herck, Koen
AU - De Bacquer, Dirk
AU - Gunter, Marc J.
AU - Huybrechts, Inge
PY - 2021
Y1 - 2021
N2 - (1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre- and postmenopausal women were followed between enrolment in 1992-2000 and December 2013-December 2015. Dietary MGD intakes were estimated at baseline through food-frequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 mu g/day compared to a reference intake of 205 mu g/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.
AB - (1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre- and postmenopausal women were followed between enrolment in 1992-2000 and December 2013-December 2015. Dietary MGD intakes were estimated at baseline through food-frequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 mu g/day compared to a reference intake of 205 mu g/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.
KW - breast cancer
KW - folate
KW - choline
KW - betaine
KW - methionine
KW - EPIC
KW - ONE-CARBON METABOLISM
KW - FOLATE INTAKE
KW - DNA METHYLATION
KW - B-VITAMINS
KW - METHIONINE
KW - DATABASE
KW - ALCOHOL
KW - CHOLINE
KW - ASSOCIATION
KW - BETAINE
U2 - 10.3390/nu13061843
DO - 10.3390/nu13061843
M3 - Journal article
C2 - 34071317
VL - 13
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 6
M1 - 1843
ER -
ID: 273531537