Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study
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Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis : results from a cohort study. / Castro-Espin, Carlota; Bonet, Catalina; Crous-Bou, Marta; Katzke, Verena; Le Cornet, Charlotte; Jannasch, Franziska; Schulze, Matthias B.; Olsen, Anja; Tjønneland, Anne; Dahm, Christina C.; Antoniussen, Christian S.; Sánchez, Maria Jose; Amiano, Pilar; Chirlaque, María Dolores; Guevara, Marcela; Agnoli, Claudia; Tumino, Rosario; Sacerdote, Carlotta; De Magistris, Maria Santucci; Sund, Malin; Bodén, Stina; Jensen, Torill Enget; Olsen, Karina Standahl; Skeie, Guri; Gunter, Marc J.; Rinaldi, Sabina; Gonzalez-Gil, Esther M.; Weiderpass, Elisabete; Christakoudi, Sofia; Heath, Alicia K.; Dossus, Laure; Agudo, Antonio.
In: British Journal of Cancer, Vol. 128, 2023, p. 1301–1310.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis
T2 - results from a cohort study
AU - Castro-Espin, Carlota
AU - Bonet, Catalina
AU - Crous-Bou, Marta
AU - Katzke, Verena
AU - Le Cornet, Charlotte
AU - Jannasch, Franziska
AU - Schulze, Matthias B.
AU - Olsen, Anja
AU - Tjønneland, Anne
AU - Dahm, Christina C.
AU - Antoniussen, Christian S.
AU - Sánchez, Maria Jose
AU - Amiano, Pilar
AU - Chirlaque, María Dolores
AU - Guevara, Marcela
AU - Agnoli, Claudia
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - De Magistris, Maria Santucci
AU - Sund, Malin
AU - Bodén, Stina
AU - Jensen, Torill Enget
AU - Olsen, Karina Standahl
AU - Skeie, Guri
AU - Gunter, Marc J.
AU - Rinaldi, Sabina
AU - Gonzalez-Gil, Esther M.
AU - Weiderpass, Elisabete
AU - Christakoudi, Sofia
AU - Heath, Alicia K.
AU - Dossus, Laure
AU - Agudo, Antonio
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - Background: Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival. Methods: The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality. Results: We included 13,270 BC cases with a mean follow-up after diagnosis of 8.6 years, representing 2340 total deaths, including 1475 BC deaths. Higher adherence to the DRRD score was associated with lower overall mortality (HR1–SD 0.92; 95%CI 0.87–0.96). Greater adherence to pro-inflammatory diets was borderline associated with 6% higher mortality HR1–SD 1.06; 95%CI 1.00–1.12. No significant association with the oestrogen-related dietary pattern was observed. None of the dietary patterns were associated with BC-specific mortality. Conclusions: Greater adherence to an anti-diabetic and anti-inflammatory diet prior to diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors.
AB - Background: Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival. Methods: The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality. Results: We included 13,270 BC cases with a mean follow-up after diagnosis of 8.6 years, representing 2340 total deaths, including 1475 BC deaths. Higher adherence to the DRRD score was associated with lower overall mortality (HR1–SD 0.92; 95%CI 0.87–0.96). Greater adherence to pro-inflammatory diets was borderline associated with 6% higher mortality HR1–SD 1.06; 95%CI 1.00–1.12. No significant association with the oestrogen-related dietary pattern was observed. None of the dietary patterns were associated with BC-specific mortality. Conclusions: Greater adherence to an anti-diabetic and anti-inflammatory diet prior to diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors.
U2 - 10.1038/s41416-023-02169-2
DO - 10.1038/s41416-023-02169-2
M3 - Journal article
C2 - 36737658
AN - SCOPUS:85147384656
VL - 128
SP - 1301
EP - 1310
JO - The British journal of cancer. Supplement
JF - The British journal of cancer. Supplement
SN - 0007-0920
ER -
ID: 338588606