Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

Research output: Contribution to journal › Journal article › Research › peer-review

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Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study. / Heath, Alicia K; Muller, David C; van den Brandt, Piet A; Critselis, Elena; Gunter, Marc; Vineis, Paolo; Weiderpass, Elisabete; Boeing, Heiner; Ferrari, Pietro; Merritt, Melissa A; Rostgaard-Hansen, Agnetha Linn; Tjønneland, Anne; Overvad, Kim; Katzke, Verena; Srour, Bernard; Masala, Giovanna; Sacerdote, Carlotta; Ricceri, Fulvio; Pasanisi, Fabrizio; Bueno-de-Mesquita, Bas; Downward, George S; Skeie, Guri; Sandanger, Torkjel M; Crous-Bou, Marta; Rodríguez-Barranco, Miguel; Amiano, Pilar; Huerta, José María; Ardanaz, Eva; Drake, Isabel; Johansson, Mikael; Johansson, Ingegerd; Key, Tim; Papadimitriou, Nikos; Riboli, Elio; Tzoulaki, Ioanna; Tsilidis, Konstantinos K.

In: International Journal of Cancer, Vol. 151, No. 11, 2022, p. 1935-1946.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Heath, AK, Muller, DC, van den Brandt, PA, Critselis, E, Gunter, M, Vineis, P, Weiderpass, E, Boeing, H, Ferrari, P, Merritt, MA, Rostgaard-Hansen, AL, Tjønneland, A, Overvad, K, Katzke, V, Srour, B, Masala, G, Sacerdote, C, Ricceri, F, Pasanisi, F, Bueno-de-Mesquita, B, Downward, GS, Skeie, G, Sandanger, TM, Crous-Bou, M, Rodríguez-Barranco, M, Amiano, P, Huerta, JM, Ardanaz, E, Drake, I, Johansson, M, Johansson, I, Key, T, Papadimitriou, N, Riboli, E, Tzoulaki, I & Tsilidis, KK 2022, 'Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study', International Journal of Cancer, vol. 151, no. 11, pp. 1935-1946. https://doi.org/10.1002/ijc.34211

APA

Heath, A. K., Muller, D. C., van den Brandt, P. A., Critselis, E., Gunter, M., Vineis, P., Weiderpass, E., Boeing, H., Ferrari, P., Merritt, M. A., Rostgaard-Hansen, A. L., Tjønneland, A., Overvad, K., Katzke, V., Srour, B., Masala, G., Sacerdote, C., Ricceri, F., Pasanisi, F., ... Tsilidis, K. K. (2022). Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study. International Journal of Cancer, 151(11), 1935-1946. https://doi.org/10.1002/ijc.34211

Vancouver

Heath AK, Muller DC, van den Brandt PA, Critselis E, Gunter M, Vineis P et al. Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study. International Journal of Cancer. 2022;151(11):1935-1946. https://doi.org/10.1002/ijc.34211

Author

Heath, Alicia K ; Muller, David C ; van den Brandt, Piet A ; Critselis, Elena ; Gunter, Marc ; Vineis, Paolo ; Weiderpass, Elisabete ; Boeing, Heiner ; Ferrari, Pietro ; Merritt, Melissa A ; Rostgaard-Hansen, Agnetha Linn ; Tjønneland, Anne ; Overvad, Kim ; Katzke, Verena ; Srour, Bernard ; Masala, Giovanna ; Sacerdote, Carlotta ; Ricceri, Fulvio ; Pasanisi, Fabrizio ; Bueno-de-Mesquita, Bas ; Downward, George S ; Skeie, Guri ; Sandanger, Torkjel M ; Crous-Bou, Marta ; Rodríguez-Barranco, Miguel ; Amiano, Pilar ; Huerta, José María ; Ardanaz, Eva ; Drake, Isabel ; Johansson, Mikael ; Johansson, Ingegerd ; Key, Tim ; Papadimitriou, Nikos ; Riboli, Elio ; Tzoulaki, Ioanna ; Tsilidis, Konstantinos K. / Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study. In: International Journal of Cancer. 2022 ; Vol. 151, No. 11. pp. 1935-1946.

Bibtex

@article{4ed1f2fd27cb4fde9f849d270aee0968,
title = "Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study",
abstract = "It is unclear whether diet, and in particular certain foods or nutrients, are associated with lung cancer risk. We assessed associations of 92 dietary factors with lung cancer risk in 327 790 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) per SD higher intake/day of each food/nutrient. Correction for multiple comparisons was performed using the false discovery rate and identified associations were evaluated in the Netherlands Cohort Study (NLCS). In EPIC, 2420 incident lung cancer cases were identified during a median of 15 years of follow-up. Higher intakes of fibre (HR per 1 SD higher intake/day = 0.91, 95% CI 0.87-0.96), fruit (HR = 0.91, 95% CI 0.86-0.96) and vitamin C (HR = 0.91, 95% CI 0.86-0.96) were associated with a lower risk of lung cancer, whereas offal (HR = 1.08, 95% CI 1.03-1.14), retinol (HR = 1.06, 95% CI 1.03-1.10) and beer/cider (HR = 1.04, 95% CI 1.02-1.07) intakes were positively associated with lung cancer risk. Associations did not differ by sex and there was less evidence for associations among never smokers. None of the six associations with overall lung cancer risk identified in EPIC were replicated in the NLCS (2861 cases), however in analyses of histological subtypes, inverse associations of fruit and vitamin C with squamous cell carcinoma were replicated in the NLCS. Overall, there is little evidence that intakes of specific foods and nutrients play a major role in primary lung cancer risk, but fruit and vitamin C intakes seem to be inversely associated with squamous cell lung cancer.",
keywords = "Cohort study, Diet, Foods, Lung cancer, Nutrients",
author = "Heath, {Alicia K} and Muller, {David C} and {van den Brandt}, {Piet A} and Elena Critselis and Marc Gunter and Paolo Vineis and Elisabete Weiderpass and Heiner Boeing and Pietro Ferrari and Merritt, {Melissa A} and Rostgaard-Hansen, {Agnetha Linn} and Anne Tj{\o}nneland and Kim Overvad and Verena Katzke and Bernard Srour and Giovanna Masala and Carlotta Sacerdote and Fulvio Ricceri and Fabrizio Pasanisi and Bas Bueno-de-Mesquita and Downward, {George S} and Guri Skeie and Sandanger, {Torkjel M} and Marta Crous-Bou and Miguel Rodr{\'i}guez-Barranco and Pilar Amiano and Huerta, {Jos{\'e} Mar{\'i}a} and Eva Ardanaz and Isabel Drake and Mikael Johansson and Ingegerd Johansson and Tim Key and Nikos Papadimitriou and Elio Riboli and Ioanna Tzoulaki and Tsilidis, {Konstantinos K}",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.",
year = "2022",
doi = "10.1002/ijc.34211",
language = "English",
volume = "151",
pages = "1935--1946",
journal = "Acta - Unio Internationalis Contra Cancrum",
issn = "0898-6924",
publisher = "JohnWiley & Sons, Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

AU - Heath, Alicia K

AU - Muller, David C

AU - van den Brandt, Piet A

AU - Critselis, Elena

AU - Gunter, Marc

AU - Vineis, Paolo

AU - Weiderpass, Elisabete

AU - Boeing, Heiner

AU - Ferrari, Pietro

AU - Merritt, Melissa A

AU - Rostgaard-Hansen, Agnetha Linn

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Katzke, Verena

AU - Srour, Bernard

AU - Masala, Giovanna

AU - Sacerdote, Carlotta

AU - Ricceri, Fulvio

AU - Pasanisi, Fabrizio

AU - Bueno-de-Mesquita, Bas

AU - Downward, George S

AU - Skeie, Guri

AU - Sandanger, Torkjel M

AU - Crous-Bou, Marta

AU - Rodríguez-Barranco, Miguel

AU - Amiano, Pilar

AU - Huerta, José María

AU - Ardanaz, Eva

AU - Drake, Isabel

AU - Johansson, Mikael

AU - Johansson, Ingegerd

AU - Key, Tim

AU - Papadimitriou, Nikos

AU - Riboli, Elio

AU - Tzoulaki, Ioanna

AU - Tsilidis, Konstantinos K

N1 - Publisher Copyright: © 2022 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.

PY - 2022

Y1 - 2022

N2 - It is unclear whether diet, and in particular certain foods or nutrients, are associated with lung cancer risk. We assessed associations of 92 dietary factors with lung cancer risk in 327 790 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) per SD higher intake/day of each food/nutrient. Correction for multiple comparisons was performed using the false discovery rate and identified associations were evaluated in the Netherlands Cohort Study (NLCS). In EPIC, 2420 incident lung cancer cases were identified during a median of 15 years of follow-up. Higher intakes of fibre (HR per 1 SD higher intake/day = 0.91, 95% CI 0.87-0.96), fruit (HR = 0.91, 95% CI 0.86-0.96) and vitamin C (HR = 0.91, 95% CI 0.86-0.96) were associated with a lower risk of lung cancer, whereas offal (HR = 1.08, 95% CI 1.03-1.14), retinol (HR = 1.06, 95% CI 1.03-1.10) and beer/cider (HR = 1.04, 95% CI 1.02-1.07) intakes were positively associated with lung cancer risk. Associations did not differ by sex and there was less evidence for associations among never smokers. None of the six associations with overall lung cancer risk identified in EPIC were replicated in the NLCS (2861 cases), however in analyses of histological subtypes, inverse associations of fruit and vitamin C with squamous cell carcinoma were replicated in the NLCS. Overall, there is little evidence that intakes of specific foods and nutrients play a major role in primary lung cancer risk, but fruit and vitamin C intakes seem to be inversely associated with squamous cell lung cancer.

AB - It is unclear whether diet, and in particular certain foods or nutrients, are associated with lung cancer risk. We assessed associations of 92 dietary factors with lung cancer risk in 327 790 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) per SD higher intake/day of each food/nutrient. Correction for multiple comparisons was performed using the false discovery rate and identified associations were evaluated in the Netherlands Cohort Study (NLCS). In EPIC, 2420 incident lung cancer cases were identified during a median of 15 years of follow-up. Higher intakes of fibre (HR per 1 SD higher intake/day = 0.91, 95% CI 0.87-0.96), fruit (HR = 0.91, 95% CI 0.86-0.96) and vitamin C (HR = 0.91, 95% CI 0.86-0.96) were associated with a lower risk of lung cancer, whereas offal (HR = 1.08, 95% CI 1.03-1.14), retinol (HR = 1.06, 95% CI 1.03-1.10) and beer/cider (HR = 1.04, 95% CI 1.02-1.07) intakes were positively associated with lung cancer risk. Associations did not differ by sex and there was less evidence for associations among never smokers. None of the six associations with overall lung cancer risk identified in EPIC were replicated in the NLCS (2861 cases), however in analyses of histological subtypes, inverse associations of fruit and vitamin C with squamous cell carcinoma were replicated in the NLCS. Overall, there is little evidence that intakes of specific foods and nutrients play a major role in primary lung cancer risk, but fruit and vitamin C intakes seem to be inversely associated with squamous cell lung cancer.

KW - Cohort study

KW - Diet

KW - Foods

KW - Lung cancer

KW - Nutrients

UR - http://www.scopus.com/inward/record.url?scp=85135518424&partnerID=8YFLogxK

U2 - 10.1002/ijc.34211

DO - 10.1002/ijc.34211

M3 - Journal article

C2 - 35830197

AN - SCOPUS:85135518424

VL - 151

SP - 1935

EP - 1946

JO - Acta - Unio Internationalis Contra Cancrum

JF - Acta - Unio Internationalis Contra Cancrum

SN - 0898-6924

IS - 11

ER -

ID: 324234754