Do WHO criteria for gestational diabetes fit a rural population in Tanzania? – A follow-up study assessing mother and child health six years after a pregnancy diagnosed with gestational diabetes
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Aims and Methods: In low- and middle- income countries (LMICs) consequences of gestational diabetes (GDM) is understudied. Using a prospective cohort of mothers (n = 197) and children (n = 251), from rural north-eastern Tanzania, we assessed prediabetes and type 2 diabetes (T2D) prevalence six years after a pregnancy with/without GDM. Results: The prevalence of prediabetes (49.4 % vs. 46.4 %) or T2D (20.0 % vs. 16.1 %), p ≥ 0.36, based on fasting plasma glucose (FPG) or HbA1c levels (prediabetes: 16.9 % vs. 13.8 % and T2D 1.2 % vs. 0 %, p = 0.47), and cardio-metabolic health parameters, were similar between women with/without previous GDM. These results were supported by similar perinatal outcomes and child health at follow-up. The overall prevalence of prediabetes/T2D was high, but no differences in other cardio-metabolic risk markers were observed in women with prediabetes/T2D compared to women with normal glucose tolerance. Conclusions: Despite high prevalence of GDM among Tanzanian women, the diagnosis was not associated with adverse pregnancy outcomes, nor with increased risk of prediabetes or T2D at follow-up. FPG and HbA1c may be poor markers for diabetes in this population, and further follow-up studies with longer time intervals are warranted to evaluate which GDM diagnostic criteria are most optimal for women in rural Tanzania and similar LMIC settings.
Original language | English |
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Article number | 111657 |
Journal | Diabetes Research and Clinical Practice |
Volume | 211 |
Number of pages | 8 |
ISSN | 0168-8227 |
DOIs | |
Publication status | Published - 2024 |
Bibliographical note
Publisher Copyright:
© 2024
- Children, Diagnosis criteria, Follow-up, GDM prevalence, Gestational diabetes mellitus, Low- and Middle-income countries, Mothers, Prediabetes, Pregnancy, Sub-Saharan Africa, Type 2 diabetes mellitus
Research areas
ID: 388830958