TY - JOUR

T1 - Does vital exhaustion increase the risk of type 2 diabetes?

T2 - A prospective study

AU - Volden, Sasia

AU - Wimmelmann, Cathrine Lawaetz

AU - Flensborg-Madsen, Trine

PY - 2017/8

Y1 - 2017/8

N2 - Background: There is evidence that both stress and depression have a causal relationship with type 2 diabetes suggesting that vital exhaustion (VE) too could be a risk factor. The association between VE and type 2 diabeteshas, however, not been investigated prospectively.Aim: To prospectively investigate whether VE is associated with an increased risk of type 2 diabetes in a Danish population.Methods: A prospective cohort study based on the Copenhagen City Heart Study (1991–1993). The degree of VE was measured among 9075 participants without type 1 or 2 diabetes at baseline. To detect type 2 diabetes in the follow-up period, two different approaches were used: In the first substudy, type 2 diabetes was defined based onblood samples and questionnaires from a follow-up study in 2001–2003 (N = 4708). The second substudy was register-based, and the study population was linked to the Danish Hospital Discharge Register to detect registrations with type 2 diabetes until 2014.Results: A high degree of VE was associated with an increased risk of developing type 2 diabetes in both substudies. In the first substudy, the OR for developing type 2 diabetes was 2.56 (95% CI, 1.53; 4,29, P < 0,001) among the quartile of participants reporting the highest degree of VE. In the second substudy, the OR was 1.31 (95% CI, 0.99; 1.72, P = 0.053) for this group.Conclusion: The results indicate that VE may be a useful measure in clinical practice in order to discover individuals at risk of type 2 diabetes.

AB - Background: There is evidence that both stress and depression have a causal relationship with type 2 diabetes suggesting that vital exhaustion (VE) too could be a risk factor. The association between VE and type 2 diabeteshas, however, not been investigated prospectively.Aim: To prospectively investigate whether VE is associated with an increased risk of type 2 diabetes in a Danish population.Methods: A prospective cohort study based on the Copenhagen City Heart Study (1991–1993). The degree of VE was measured among 9075 participants without type 1 or 2 diabetes at baseline. To detect type 2 diabetes in the follow-up period, two different approaches were used: In the first substudy, type 2 diabetes was defined based onblood samples and questionnaires from a follow-up study in 2001–2003 (N = 4708). The second substudy was register-based, and the study population was linked to the Danish Hospital Discharge Register to detect registrations with type 2 diabetes until 2014.Results: A high degree of VE was associated with an increased risk of developing type 2 diabetes in both substudies. In the first substudy, the OR for developing type 2 diabetes was 2.56 (95% CI, 1.53; 4,29, P < 0,001) among the quartile of participants reporting the highest degree of VE. In the second substudy, the OR was 1.31 (95% CI, 0.99; 1.72, P = 0.053) for this group.Conclusion: The results indicate that VE may be a useful measure in clinical practice in order to discover individuals at risk of type 2 diabetes.

U2 - 10.1016/j.jpsychores.2017.06.001

DO - 10.1016/j.jpsychores.2017.06.001

M3 - Journal article

C2 - 28712434

VL - 99

SP - 82

EP - 88

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

SN - 0022-3999

ER -