Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia
Research output: Contribution to journal › Journal article › Research › peer-review
12 AIDS/ARC patients with or suspected of Pneumocystis carinii pneumonia were treated with co-trimoxazole and received supplementary folic or folinic acid to avoid peripheral blood cytopenia. Most patients developed decreased numbers of neutrophils and hemoglobin while receiving co-trimoxazole. Supplementary folate/folinate could not abolish the drug-induced cytopenia. Routine prescription of folinic acid is not recommended. Folic acid is cheap and may be beneficial and should be prescribed.
| Original language | English |
|---|---|
| Journal | Scandinavian Journal of Infectious Diseases |
| Volume | 20 |
| Issue number | 6 |
| Pages (from-to) | 685-6 |
| Number of pages | 2 |
| ISSN | 0036-5548 |
| Publication status | Published - 1 Jan 1988 |
- AIDS-Related Complex, Acquired Immunodeficiency Syndrome, Anemia, Drug Combinations, Folic Acid, Hematologic Diseases, Humans, Leucovorin, Leukopenia, Pneumonia, Pneumocystis, Prospective Studies, Sulfamethoxazole, Thrombocytopenia, Time Factors, Trimethoprim, Trimethoprim-Sulfamethoxazole Combination
Research areas
ID: 33891505