Embryo quality and developmental potential is compromised by age
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Embryo quality and developmental potential is compromised by age. / Ziebe, S; Loft, A; Petersen, J H; Andersen, A G; Lindenberg, S; Petersen, K; Andersen, A N.
In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 80, No. 2, 02.2001, p. 169-74.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Embryo quality and developmental potential is compromised by age
AU - Ziebe, S
AU - Loft, A
AU - Petersen, J H
AU - Andersen, A G
AU - Lindenberg, S
AU - Petersen, K
AU - Andersen, A N
PY - 2001/2
Y1 - 2001/2
N2 - AIMS: The aim of this retrospective study was to assess whether and how the age of the woman affects the quality and developmental potential of the oocytes and embryos in an ART program.METHOD AND MATERIAL: A total of 878 IVF cycles was included as a consecutive series of single transfers (n=292), dual transfers (n=366) and triple transfers (n=220), where all the transferred embryos in each cycle were of identical quality score and identical cleavage stage.RESULTS: We found a highly significant decrease in oocyte recovery with increasing age with about one oocyte per 2.3 years (95% CI 1.8 years to 3.1 years, p<0.0001). Further, we found that the number of oocytes that cleaved declined significantly with increasing age with one per 3.7 years (95% CI 2.7 years to 5.5 years, p<0.0001). This decline was mainly due to the decline in number of oocytes retrieved as the ratio of aspirated oocytes that cleaved with increasing age (approx. -0.04/10 year 95% CI: -0.10; +0.009) was not significantly different (p=0.10). The percentage of transfers using fragmented embryos did not increase significantly with increasing age (p=0.08). The odds of fragmentation increased by 3% per year. The average number of embryos transferred decreased significantly (p=0.03) with age from approximately 2.1 at the age of 25 to approximately 1.8 at the age of 40. In a selected subgroup of embryos all consisting of good quality embryos, a significant decrease was found in implantation rate with increasing age (approx. -0.08/10 years, 95% CI: -1.6; +0.00, p=0.05). Of the 357 pregnancies achieved in this study we found a significantly decreased ongoing pregnancy rate and a significantly increased abortion rate with increasing age (p=0.03). The decrease in the rate of ongoing pregnancies was almost linear, decreasing by approximately 1.5% per year.CONCLUSIONS: We conclude that age has an impact throughout a woman's reproductive life and that it is important to realize that the age-related decline in fertility may start already in the late twenties and not in the mid-thirties as is generally assumed.
AB - AIMS: The aim of this retrospective study was to assess whether and how the age of the woman affects the quality and developmental potential of the oocytes and embryos in an ART program.METHOD AND MATERIAL: A total of 878 IVF cycles was included as a consecutive series of single transfers (n=292), dual transfers (n=366) and triple transfers (n=220), where all the transferred embryos in each cycle were of identical quality score and identical cleavage stage.RESULTS: We found a highly significant decrease in oocyte recovery with increasing age with about one oocyte per 2.3 years (95% CI 1.8 years to 3.1 years, p<0.0001). Further, we found that the number of oocytes that cleaved declined significantly with increasing age with one per 3.7 years (95% CI 2.7 years to 5.5 years, p<0.0001). This decline was mainly due to the decline in number of oocytes retrieved as the ratio of aspirated oocytes that cleaved with increasing age (approx. -0.04/10 year 95% CI: -0.10; +0.009) was not significantly different (p=0.10). The percentage of transfers using fragmented embryos did not increase significantly with increasing age (p=0.08). The odds of fragmentation increased by 3% per year. The average number of embryos transferred decreased significantly (p=0.03) with age from approximately 2.1 at the age of 25 to approximately 1.8 at the age of 40. In a selected subgroup of embryos all consisting of good quality embryos, a significant decrease was found in implantation rate with increasing age (approx. -0.08/10 years, 95% CI: -1.6; +0.00, p=0.05). Of the 357 pregnancies achieved in this study we found a significantly decreased ongoing pregnancy rate and a significantly increased abortion rate with increasing age (p=0.03). The decrease in the rate of ongoing pregnancies was almost linear, decreasing by approximately 1.5% per year.CONCLUSIONS: We conclude that age has an impact throughout a woman's reproductive life and that it is important to realize that the age-related decline in fertility may start already in the late twenties and not in the mid-thirties as is generally assumed.
KW - Adult
KW - Cleavage Stage, Ovum/physiology
KW - Embryo Implantation/physiology
KW - Embryo Transfer
KW - Embryo, Mammalian/physiology
KW - Female
KW - Fertilization in Vitro
KW - Humans
KW - Maternal Age
KW - Middle Aged
KW - Oocytes/growth & development
KW - Pregnancy
KW - Pregnancy Outcome
KW - Retrospective Studies
U2 - 10.1034/j.1600-0412.2001.080002169.x
DO - 10.1034/j.1600-0412.2001.080002169.x
M3 - Journal article
C2 - 11167214
VL - 80
SP - 169
EP - 174
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 2
ER -
ID: 321161883