Ethnic coefficients for glomerular filtration rate estimation by the Modification of Diet in Renal Disease study equations in the Korean population

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  • Chung Sik Lee
  • Ran-hui Cha
  • Lim, Youn Hee
  • Ho Kim
  • Ka Heon Song
  • Namyi Gu
  • Kyung Sang Yu
  • Chun Soo Lim
  • Jin Suk Han
  • Suhnggwon Kim
  • Yon Su Kim

Race and ethnicity are influential in estimating glomerular filtration rate (GFR). We aimed to find the Korean coefficients for the Modification of Diet in Renal Disease (MDRD) study equations and to obtain novel proper estimation equations. Reference GFR was measured by systemic inulin clearance. Serum creatinine (SCr) values were measured by the alkaline picrate Jaffé kinetic method, then, recalibrated to CX3 analyzer and to isotope dilution mass spectrometry (IDMS). The Korean coefficients for the 4 and 6 variable MDRD and IDMS MDRD study equations based on the SCr recalibrated to CX3 and to IDMS were 0.73989/0.74254 and 0.99096/0.9554, respectively. Coefficients for the 4 and 6 variable MDRD equations based on the SCr measured by Jaffé method were 1.09825 and 1.04334, respectively. The modified equations showed better performances than the original equations. The novel 4 variable equations for Korean based on the SCr measured and recalibrated to IDMS were 107.904×SCr(-1.009)×age(-0.02) (×0.667, if woman) and 87.832×SCr(-0.882)×age(0.01) (×0.653, if woman), respectively. Modified estimations of the MDRD and IDMS MDRD study equations with ethnic coefficients and the novel equations improve the performance of GFR estimation for the overall renal function.

Original languageEnglish
JournalJournal of Korean Medical Science
Volume25
Issue number11
Pages (from-to)1616-25
Number of pages10
ISSN1011-8934
DOIs
Publication statusPublished - Nov 2010

    Research areas

  • Adult, Aged, Aged, 80 and over, Algorithms, Creatinine/blood, Diet, Female, Glomerular Filtration Rate, Humans, Inulin/metabolism, Kidney Diseases/ethnology, Male, Mass Spectrometry, Middle Aged, Republic of Korea/ethnology

ID: 230072498