Executive function predicts cognitive-behavioral therapy response in childhood obsessive-compulsive disorder

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Executive function predicts cognitive-behavioral therapy response in childhood obsessive-compulsive disorder. / Hybel, Katja Anna; Mortensen, Erik Lykke; Lambek, Rikke; Højgaard, David R. M. A.; Thomsen, Per Hove.

In: Behaviour Research and Therapy, Vol. 99, 12.2017, p. 11-18.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Hybel, KA, Mortensen, EL, Lambek, R, Højgaard, DRMA & Thomsen, PH 2017, 'Executive function predicts cognitive-behavioral therapy response in childhood obsessive-compulsive disorder', Behaviour Research and Therapy, vol. 99, pp. 11-18. https://doi.org/10.1016/j.brat.2017.08.009

APA

Hybel, K. A., Mortensen, E. L., Lambek, R., Højgaard, D. R. M. A., & Thomsen, P. H. (2017). Executive function predicts cognitive-behavioral therapy response in childhood obsessive-compulsive disorder. Behaviour Research and Therapy, 99, 11-18. https://doi.org/10.1016/j.brat.2017.08.009

Vancouver

Hybel KA, Mortensen EL, Lambek R, Højgaard DRMA, Thomsen PH. Executive function predicts cognitive-behavioral therapy response in childhood obsessive-compulsive disorder. Behaviour Research and Therapy. 2017 Dec;99:11-18. https://doi.org/10.1016/j.brat.2017.08.009

Author

Hybel, Katja Anna ; Mortensen, Erik Lykke ; Lambek, Rikke ; Højgaard, David R. M. A. ; Thomsen, Per Hove. / Executive function predicts cognitive-behavioral therapy response in childhood obsessive-compulsive disorder. In: Behaviour Research and Therapy. 2017 ; Vol. 99. pp. 11-18.

Bibtex

@article{4a7c11d4df224a99b57ceb35f77361eb,
title = "Executive function predicts cognitive-behavioral therapy response in childhood obsessive-compulsive disorder",
abstract = "Cognitive-behavioral therapy (CBT) is considered first-line treatment for childhood obsessive-compulsive disorder (OCD). Despite CBT's efficacy, too many children and adolescents do not fully respond to treatment, making the identification of predictors of treatment response highly relevant. Executive functions (EF) have been suggested to constitute such predictors, but studies with pediatric samples are scarce. In the present study, we investigated latent level EF test performance and ratings of daily life EF behavior as predictors of CBT response in pediatric OCD. We further examined the stability of EF from pre-to post-treatment and the association of EF changes with OCD severity change. EF test performance significantly predicted exposure-based CBT outcome. Patients with better EF test performance had significantly elevated risk of non-response relative to patients with poorer performance. Daily life EF behavior in OCD probands improved after treatment relative to controls. The findings suggest that EF performance impacts CBT outcome, and that exposure-based CBT is well-suited for children and adolescents with OCD and poorer EF test performance. This study supports the relevance of EF in CBT for childhood OCD and denotes a possible need for development of enhanced treatments for children and adolescents with OCD and superior EF performance.",
keywords = "Obsessive-compulsive disorder, Executive function, Cognitive-behavioral therapy, Children, Adolescents",
author = "Hybel, {Katja Anna} and Mortensen, {Erik Lykke} and Rikke Lambek and H{\o}jgaard, {David R. M. A.} and Thomsen, {Per Hove}",
year = "2017",
month = "12",
doi = "10.1016/j.brat.2017.08.009",
language = "English",
volume = "99",
pages = "11--18",
journal = "Behaviour Research and Therapy",
issn = "0005-7967",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Executive function predicts cognitive-behavioral therapy response in childhood obsessive-compulsive disorder

AU - Hybel, Katja Anna

AU - Mortensen, Erik Lykke

AU - Lambek, Rikke

AU - Højgaard, David R. M. A.

AU - Thomsen, Per Hove

PY - 2017/12

Y1 - 2017/12

N2 - Cognitive-behavioral therapy (CBT) is considered first-line treatment for childhood obsessive-compulsive disorder (OCD). Despite CBT's efficacy, too many children and adolescents do not fully respond to treatment, making the identification of predictors of treatment response highly relevant. Executive functions (EF) have been suggested to constitute such predictors, but studies with pediatric samples are scarce. In the present study, we investigated latent level EF test performance and ratings of daily life EF behavior as predictors of CBT response in pediatric OCD. We further examined the stability of EF from pre-to post-treatment and the association of EF changes with OCD severity change. EF test performance significantly predicted exposure-based CBT outcome. Patients with better EF test performance had significantly elevated risk of non-response relative to patients with poorer performance. Daily life EF behavior in OCD probands improved after treatment relative to controls. The findings suggest that EF performance impacts CBT outcome, and that exposure-based CBT is well-suited for children and adolescents with OCD and poorer EF test performance. This study supports the relevance of EF in CBT for childhood OCD and denotes a possible need for development of enhanced treatments for children and adolescents with OCD and superior EF performance.

AB - Cognitive-behavioral therapy (CBT) is considered first-line treatment for childhood obsessive-compulsive disorder (OCD). Despite CBT's efficacy, too many children and adolescents do not fully respond to treatment, making the identification of predictors of treatment response highly relevant. Executive functions (EF) have been suggested to constitute such predictors, but studies with pediatric samples are scarce. In the present study, we investigated latent level EF test performance and ratings of daily life EF behavior as predictors of CBT response in pediatric OCD. We further examined the stability of EF from pre-to post-treatment and the association of EF changes with OCD severity change. EF test performance significantly predicted exposure-based CBT outcome. Patients with better EF test performance had significantly elevated risk of non-response relative to patients with poorer performance. Daily life EF behavior in OCD probands improved after treatment relative to controls. The findings suggest that EF performance impacts CBT outcome, and that exposure-based CBT is well-suited for children and adolescents with OCD and poorer EF test performance. This study supports the relevance of EF in CBT for childhood OCD and denotes a possible need for development of enhanced treatments for children and adolescents with OCD and superior EF performance.

KW - Obsessive-compulsive disorder

KW - Executive function

KW - Cognitive-behavioral therapy

KW - Children

KW - Adolescents

U2 - 10.1016/j.brat.2017.08.009

DO - 10.1016/j.brat.2017.08.009

M3 - Journal article

C2 - 28881220

VL - 99

SP - 11

EP - 18

JO - Behaviour Research and Therapy

JF - Behaviour Research and Therapy

SN - 0005-7967

ER -

ID: 189352415