First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale
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First steps toward harmonized human biomonitoring in Europe : demonstration project to perform human biomonitoring on a European scale. / Den Hond, Elly; Govarts, Eva; Willems, Hanny; Smolders, Roel; Casteleyn, Ludwine; Kolossa-Gehring, Marike; Schwedler, Gerda; Seiwert, Margarete; Fiddicke, Ulrike; Castaño, Argelia; Esteban, Marta; Angerer, Jürgen; Koch, Holger M; Schindler, Birgit K; Sepai, Ovnair; Exley, Karen; Bloemen, Louis; Horvat, Milena; Knudsen, Lisbeth E.; Joas, Anke; Joas, Reinhard; Biot, Pierre; Aerts, Dominique; Koppen, Gudrun; Katsonouri, Andromachi; Hadjipanayis, Adamos; Krskova, Andrea; Maly, Marek; Mørck, Thit A; Rudnai, Peter; Kozepesy, Szilvia; Mulcahy, Maurice; Mannion, Rory; Gutleb, Arno C; Fischer, Marc E; Ligocka, Danuta; Jakubowski, Marek; Reis, M Fátima; Namorado, Sónia; Gurzau, Anca Elena; Lupsa, Ioana-Rodica; Halzlova, Katarina; Jajcaj, Michal; Mazej, Darja; Tratnik, Janja Snoj; López, Ana; Lopez, Estrella; Berglund, Marika; Larsson, Kristin; Lehmann, Andrea; Crettaz, Pierre; Schoeters, Greet.
In: Environmental Health Perspectives, Vol. 123, No. 3, 01.03.2015, p. 255-263.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - First steps toward harmonized human biomonitoring in Europe
T2 - demonstration project to perform human biomonitoring on a European scale
AU - Den Hond, Elly
AU - Govarts, Eva
AU - Willems, Hanny
AU - Smolders, Roel
AU - Casteleyn, Ludwine
AU - Kolossa-Gehring, Marike
AU - Schwedler, Gerda
AU - Seiwert, Margarete
AU - Fiddicke, Ulrike
AU - Castaño, Argelia
AU - Esteban, Marta
AU - Angerer, Jürgen
AU - Koch, Holger M
AU - Schindler, Birgit K
AU - Sepai, Ovnair
AU - Exley, Karen
AU - Bloemen, Louis
AU - Horvat, Milena
AU - Knudsen, Lisbeth E.
AU - Joas, Anke
AU - Joas, Reinhard
AU - Biot, Pierre
AU - Aerts, Dominique
AU - Koppen, Gudrun
AU - Katsonouri, Andromachi
AU - Hadjipanayis, Adamos
AU - Krskova, Andrea
AU - Maly, Marek
AU - Mørck, Thit A
AU - Rudnai, Peter
AU - Kozepesy, Szilvia
AU - Mulcahy, Maurice
AU - Mannion, Rory
AU - Gutleb, Arno C
AU - Fischer, Marc E
AU - Ligocka, Danuta
AU - Jakubowski, Marek
AU - Reis, M Fátima
AU - Namorado, Sónia
AU - Gurzau, Anca Elena
AU - Lupsa, Ioana-Rodica
AU - Halzlova, Katarina
AU - Jajcaj, Michal
AU - Mazej, Darja
AU - Tratnik, Janja Snoj
AU - López, Ana
AU - Lopez, Estrella
AU - Berglund, Marika
AU - Larsson, Kristin
AU - Lehmann, Andrea
AU - Crettaz, Pierre
AU - Schoeters, Greet
PY - 2015/3/1
Y1 - 2015/3/1
N2 - BACKGROUND: For Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the internal individual chemical environment is expected to enhance understanding of the environmental threats to health.OBJECTIVES: We developed and applied a harmonized protocol to collect comparable human biomonitoring data all over Europe.METHODS: In 17 European countries, we measured mercury in hair and cotinine, phthalate metabolites, and cadmium in urine of 1,844 children (5-11 years of age) and their mothers. Specimens were collected over a 5-month period in 2011-2012. We obtained information on personal characteristics, environment, and lifestyle. We used the resulting database to compare concentrations of exposure biomarkers within Europe, to identify determinants of exposure, and to compare exposure biomarkers with health-based guidelines.RESULTS: Biomarker concentrations showed a wide variability in the European population. However, levels in children and mothers were highly correlated. Most biomarker concentrations were below the health-based guidance values.CONCLUSIONS: We have taken the first steps to assess personal chemical exposures in Europe as a whole. Key success factors were the harmonized protocol development, intensive training and capacity building for field work, chemical analysis and communication, as well as stringent quality control programs for chemical and data analysis. Our project demonstrates the feasibility of a Europe-wide human biomonitoring framework to support the decision-making process of environmental measures to protect public health.
AB - BACKGROUND: For Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the internal individual chemical environment is expected to enhance understanding of the environmental threats to health.OBJECTIVES: We developed and applied a harmonized protocol to collect comparable human biomonitoring data all over Europe.METHODS: In 17 European countries, we measured mercury in hair and cotinine, phthalate metabolites, and cadmium in urine of 1,844 children (5-11 years of age) and their mothers. Specimens were collected over a 5-month period in 2011-2012. We obtained information on personal characteristics, environment, and lifestyle. We used the resulting database to compare concentrations of exposure biomarkers within Europe, to identify determinants of exposure, and to compare exposure biomarkers with health-based guidelines.RESULTS: Biomarker concentrations showed a wide variability in the European population. However, levels in children and mothers were highly correlated. Most biomarker concentrations were below the health-based guidance values.CONCLUSIONS: We have taken the first steps to assess personal chemical exposures in Europe as a whole. Key success factors were the harmonized protocol development, intensive training and capacity building for field work, chemical analysis and communication, as well as stringent quality control programs for chemical and data analysis. Our project demonstrates the feasibility of a Europe-wide human biomonitoring framework to support the decision-making process of environmental measures to protect public health.
U2 - 10.1289/ehp.1408616
DO - 10.1289/ehp.1408616
M3 - Journal article
C2 - 25493439
VL - 123
SP - 255
EP - 263
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 3
ER -
ID: 137756544