Flavonoid intakes inversely associate with COPD in smokers

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Flavonoid intakes inversely associate with COPD in smokers. / Bondonno, Nicola P.; Parmenter, Benjamin H.; Dalgaard, Frederik; Murray, Kevin; Rasmussen, Daniel Bech; Kyrø, Cecilie; Cassidy, Aedin; Bondonno, Catherine P.; Lewis, Joshua R.; Croft, Kevin D.; Gislason, Gunnar; Scalbert, Augustin; Tjonneland, Anne; Overvad, Kim; Olsen, Anja; Hodgson, Jonathan M.

In: European Respiratory Journal. Supplement, Vol. 60, No. 2, 2102604, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bondonno, NP, Parmenter, BH, Dalgaard, F, Murray, K, Rasmussen, DB, Kyrø, C, Cassidy, A, Bondonno, CP, Lewis, JR, Croft, KD, Gislason, G, Scalbert, A, Tjonneland, A, Overvad, K, Olsen, A & Hodgson, JM 2022, 'Flavonoid intakes inversely associate with COPD in smokers', European Respiratory Journal. Supplement, vol. 60, no. 2, 2102604. https://doi.org/10.1183/13993003.02604-2021

APA

Bondonno, N. P., Parmenter, B. H., Dalgaard, F., Murray, K., Rasmussen, D. B., Kyrø, C., Cassidy, A., Bondonno, C. P., Lewis, J. R., Croft, K. D., Gislason, G., Scalbert, A., Tjonneland, A., Overvad, K., Olsen, A., & Hodgson, J. M. (2022). Flavonoid intakes inversely associate with COPD in smokers. European Respiratory Journal. Supplement, 60(2), [2102604]. https://doi.org/10.1183/13993003.02604-2021

Vancouver

Bondonno NP, Parmenter BH, Dalgaard F, Murray K, Rasmussen DB, Kyrø C et al. Flavonoid intakes inversely associate with COPD in smokers. European Respiratory Journal. Supplement. 2022;60(2). 2102604. https://doi.org/10.1183/13993003.02604-2021

Author

Bondonno, Nicola P. ; Parmenter, Benjamin H. ; Dalgaard, Frederik ; Murray, Kevin ; Rasmussen, Daniel Bech ; Kyrø, Cecilie ; Cassidy, Aedin ; Bondonno, Catherine P. ; Lewis, Joshua R. ; Croft, Kevin D. ; Gislason, Gunnar ; Scalbert, Augustin ; Tjonneland, Anne ; Overvad, Kim ; Olsen, Anja ; Hodgson, Jonathan M. / Flavonoid intakes inversely associate with COPD in smokers. In: European Respiratory Journal. Supplement. 2022 ; Vol. 60, No. 2.

Bibtex

@article{88d85abfb6d04ffba10fd8822c1a75af,
title = "Flavonoid intakes inversely associate with COPD in smokers",
abstract = "Introduction Higher flavonoid intakes are beneficially associated with pulmonary function parameters; however, their association with chronic obstructive pulmonary disease (COPD) is unknown. This study aimed to examine associations between intakes of 1) total flavonoids, 2) flavonoid subclasses and 3) major flavonoid compounds with incident COPD in participants from the Danish Diet, Cancer and Health study.Methods This prospective cohort included 55 413 men and women without COPD, aged 50-65 years at recruitment. Habitual flavonoid intakes at baseline were estimated from a food frequency questionnaire using Phenol-Explorer. Danish nationwide registers were used to identify incident cases of COPD. Associations were modelled using restricted cubic splines within Cox proportional hazards models.Results During 23 years of follow-up, 5557 participants were diagnosed with COPD. Of these, 4013 were current smokers, 1062 were former smokers and 482 were never-smokers. After multivariable adjustments, participants with the highest total flavonoid intakes had a 20% lower risk of COPD than those with the lowest intakes (quintile 5 versus quintile 1: HR 0.80, 95% CI 0.74-0.87); a 6-22% lower risk was observed for each flavonoid subclass. The inverse association between total flavonoid intake and COPD was present in both men and women but only in current smokers (HR 0.77, 95% CI 0.70-0.84) and former smokers (HR 0.82, 95% CI 0.69-0.97), not never-smokers. Furthermore, higher flavonoid intakes appeared to lessen, but not negate, the higher risk of COPD associated with smoking intensity.Conclusion Dietary flavonoids may be important for partially mitigating the risk of smoking-related COPD. However, smoking cessation should remain the highest priority.",
keywords = "OBSTRUCTIVE PULMONARY-DISEASE, OXIDATIVE STRESS, PROSPECTIVE COHORT, CIGARETTE-SMOKE, INFLAMMATION, DECLINE, WOMEN, DIET, RISK",
author = "Bondonno, {Nicola P.} and Parmenter, {Benjamin H.} and Frederik Dalgaard and Kevin Murray and Rasmussen, {Daniel Bech} and Cecilie Kyr{\o} and Aedin Cassidy and Bondonno, {Catherine P.} and Lewis, {Joshua R.} and Croft, {Kevin D.} and Gunnar Gislason and Augustin Scalbert and Anne Tjonneland and Kim Overvad and Anja Olsen and Hodgson, {Jonathan M.}",
year = "2022",
doi = "10.1183/13993003.02604-2021",
language = "English",
volume = "60",
journal = "European Respiratory Journal. Supplement",
issn = "0904-1850",
publisher = "European Respiratory Society",
number = "2",

}

RIS

TY - JOUR

T1 - Flavonoid intakes inversely associate with COPD in smokers

AU - Bondonno, Nicola P.

AU - Parmenter, Benjamin H.

AU - Dalgaard, Frederik

AU - Murray, Kevin

AU - Rasmussen, Daniel Bech

AU - Kyrø, Cecilie

AU - Cassidy, Aedin

AU - Bondonno, Catherine P.

AU - Lewis, Joshua R.

AU - Croft, Kevin D.

AU - Gislason, Gunnar

AU - Scalbert, Augustin

AU - Tjonneland, Anne

AU - Overvad, Kim

AU - Olsen, Anja

AU - Hodgson, Jonathan M.

PY - 2022

Y1 - 2022

N2 - Introduction Higher flavonoid intakes are beneficially associated with pulmonary function parameters; however, their association with chronic obstructive pulmonary disease (COPD) is unknown. This study aimed to examine associations between intakes of 1) total flavonoids, 2) flavonoid subclasses and 3) major flavonoid compounds with incident COPD in participants from the Danish Diet, Cancer and Health study.Methods This prospective cohort included 55 413 men and women without COPD, aged 50-65 years at recruitment. Habitual flavonoid intakes at baseline were estimated from a food frequency questionnaire using Phenol-Explorer. Danish nationwide registers were used to identify incident cases of COPD. Associations were modelled using restricted cubic splines within Cox proportional hazards models.Results During 23 years of follow-up, 5557 participants were diagnosed with COPD. Of these, 4013 were current smokers, 1062 were former smokers and 482 were never-smokers. After multivariable adjustments, participants with the highest total flavonoid intakes had a 20% lower risk of COPD than those with the lowest intakes (quintile 5 versus quintile 1: HR 0.80, 95% CI 0.74-0.87); a 6-22% lower risk was observed for each flavonoid subclass. The inverse association between total flavonoid intake and COPD was present in both men and women but only in current smokers (HR 0.77, 95% CI 0.70-0.84) and former smokers (HR 0.82, 95% CI 0.69-0.97), not never-smokers. Furthermore, higher flavonoid intakes appeared to lessen, but not negate, the higher risk of COPD associated with smoking intensity.Conclusion Dietary flavonoids may be important for partially mitigating the risk of smoking-related COPD. However, smoking cessation should remain the highest priority.

AB - Introduction Higher flavonoid intakes are beneficially associated with pulmonary function parameters; however, their association with chronic obstructive pulmonary disease (COPD) is unknown. This study aimed to examine associations between intakes of 1) total flavonoids, 2) flavonoid subclasses and 3) major flavonoid compounds with incident COPD in participants from the Danish Diet, Cancer and Health study.Methods This prospective cohort included 55 413 men and women without COPD, aged 50-65 years at recruitment. Habitual flavonoid intakes at baseline were estimated from a food frequency questionnaire using Phenol-Explorer. Danish nationwide registers were used to identify incident cases of COPD. Associations were modelled using restricted cubic splines within Cox proportional hazards models.Results During 23 years of follow-up, 5557 participants were diagnosed with COPD. Of these, 4013 were current smokers, 1062 were former smokers and 482 were never-smokers. After multivariable adjustments, participants with the highest total flavonoid intakes had a 20% lower risk of COPD than those with the lowest intakes (quintile 5 versus quintile 1: HR 0.80, 95% CI 0.74-0.87); a 6-22% lower risk was observed for each flavonoid subclass. The inverse association between total flavonoid intake and COPD was present in both men and women but only in current smokers (HR 0.77, 95% CI 0.70-0.84) and former smokers (HR 0.82, 95% CI 0.69-0.97), not never-smokers. Furthermore, higher flavonoid intakes appeared to lessen, but not negate, the higher risk of COPD associated with smoking intensity.Conclusion Dietary flavonoids may be important for partially mitigating the risk of smoking-related COPD. However, smoking cessation should remain the highest priority.

KW - OBSTRUCTIVE PULMONARY-DISEASE

KW - OXIDATIVE STRESS

KW - PROSPECTIVE COHORT

KW - CIGARETTE-SMOKE

KW - INFLAMMATION

KW - DECLINE

KW - WOMEN

KW - DIET

KW - RISK

U2 - 10.1183/13993003.02604-2021

DO - 10.1183/13993003.02604-2021

M3 - Journal article

C2 - 35058251

VL - 60

JO - European Respiratory Journal. Supplement

JF - European Respiratory Journal. Supplement

SN - 0904-1850

IS - 2

M1 - 2102604

ER -

ID: 327511634