Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models. / Møller, Peter; Risom, Lotte; Lundby, Carsten; Mikkelsen, Lone; Loft, Steffen.

In: IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, Vol. 60, No. 11, 2008, p. 707-23.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Møller, P, Risom, L, Lundby, C, Mikkelsen, L & Loft, S 2008, 'Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models', IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, vol. 60, no. 11, pp. 707-23. https://doi.org/10.1002/iub.109

APA

Møller, P., Risom, L., Lundby, C., Mikkelsen, L., & Loft, S. (2008). Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models. IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 60(11), 707-23. https://doi.org/10.1002/iub.109

Vancouver

Møller P, Risom L, Lundby C, Mikkelsen L, Loft S. Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models. IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology. 2008;60(11):707-23. https://doi.org/10.1002/iub.109

Author

Møller, Peter ; Risom, Lotte ; Lundby, Carsten ; Mikkelsen, Lone ; Loft, Steffen. / Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models. In: IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology. 2008 ; Vol. 60, No. 11. pp. 707-23.

Bibtex

@article{a4cbd660e93a11ddbf70000ea68e967b,
title = "Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models",
abstract = "The objective of this review was to evaluate the association between hypoxia and oxidative damage to DNA and lipids. Evaluation criteria encompassed specificity and validation status of the biomarkers, study design, strength of the association, dose-response relationship, biological plausibility, analogous exposures, and effect modification by intervention. The collective interpretation indicates persuasive evidence from the studies in humans for an association between hypoxia and elevated levels of oxidative damage to DNA and lipids. The levels of oxidatively generated DNA lesions and lipid peroxidation products depend on both the duration and severity of the exposure to hypoxia. Largest effects are observed with exposure to hypoxia at high altitude, but other factors, including ultraviolet light, exercise, exertion, and low intake of antioxidants, might contribute to the effect observed in subjects at high altitude. Most of the animal experimental models should be interpreted with caution because the assays for assessment of lipid peroxidation products have suboptimal validity.",
author = "Peter M{\o}ller and Lotte Risom and Carsten Lundby and Lone Mikkelsen and Steffen Loft",
note = "Keywords: Altitude; Animals; Anoxia; Antioxidants; Biological Markers; DNA Damage; Exercise; Humans; Lipid Peroxidation; Models, Animal; Models, Theoretical; Oxidation-Reduction; Oxidative Stress",
year = "2008",
doi = "10.1002/iub.109",
language = "English",
volume = "60",
pages = "707--23",
journal = "I U B M B Life",
issn = "1521-6543",
publisher = "Wiley Online",
number = "11",

}

RIS

TY - JOUR

T1 - Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models

AU - Møller, Peter

AU - Risom, Lotte

AU - Lundby, Carsten

AU - Mikkelsen, Lone

AU - Loft, Steffen

N1 - Keywords: Altitude; Animals; Anoxia; Antioxidants; Biological Markers; DNA Damage; Exercise; Humans; Lipid Peroxidation; Models, Animal; Models, Theoretical; Oxidation-Reduction; Oxidative Stress

PY - 2008

Y1 - 2008

N2 - The objective of this review was to evaluate the association between hypoxia and oxidative damage to DNA and lipids. Evaluation criteria encompassed specificity and validation status of the biomarkers, study design, strength of the association, dose-response relationship, biological plausibility, analogous exposures, and effect modification by intervention. The collective interpretation indicates persuasive evidence from the studies in humans for an association between hypoxia and elevated levels of oxidative damage to DNA and lipids. The levels of oxidatively generated DNA lesions and lipid peroxidation products depend on both the duration and severity of the exposure to hypoxia. Largest effects are observed with exposure to hypoxia at high altitude, but other factors, including ultraviolet light, exercise, exertion, and low intake of antioxidants, might contribute to the effect observed in subjects at high altitude. Most of the animal experimental models should be interpreted with caution because the assays for assessment of lipid peroxidation products have suboptimal validity.

AB - The objective of this review was to evaluate the association between hypoxia and oxidative damage to DNA and lipids. Evaluation criteria encompassed specificity and validation status of the biomarkers, study design, strength of the association, dose-response relationship, biological plausibility, analogous exposures, and effect modification by intervention. The collective interpretation indicates persuasive evidence from the studies in humans for an association between hypoxia and elevated levels of oxidative damage to DNA and lipids. The levels of oxidatively generated DNA lesions and lipid peroxidation products depend on both the duration and severity of the exposure to hypoxia. Largest effects are observed with exposure to hypoxia at high altitude, but other factors, including ultraviolet light, exercise, exertion, and low intake of antioxidants, might contribute to the effect observed in subjects at high altitude. Most of the animal experimental models should be interpreted with caution because the assays for assessment of lipid peroxidation products have suboptimal validity.

U2 - 10.1002/iub.109

DO - 10.1002/iub.109

M3 - Journal article

C2 - 18698611

VL - 60

SP - 707

EP - 723

JO - I U B M B Life

JF - I U B M B Life

SN - 1521-6543

IS - 11

ER -

ID: 9910189