Indoor and outdoor exposure to ultrafine, fine and microbiologically derived particulate matter related to cardiovascular and respiratory effects in a panel of elderly urban citizens

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Indoor and outdoor exposure to ultrafine, fine and microbiologically derived particulate matter related to cardiovascular and respiratory effects in a panel of elderly urban citizens. / Karottki, Dorina Gabriela; Spilak, Michal; Frederiksen, Marie; Andersen, Zorana Jovanovic; Madsen, Anne Mette; Ketzel, Matthias; Massling, Andreas; Gunnarsen, Lars; Møller, Peter; Loft, Steffen.

In: International Journal of Environmental Research and Public Health, Vol. 12, No. 2, 02.02.2015, p. 1667-1686.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Karottki, DG, Spilak, M, Frederiksen, M, Andersen, ZJ, Madsen, AM, Ketzel, M, Massling, A, Gunnarsen, L, Møller, P & Loft, S 2015, 'Indoor and outdoor exposure to ultrafine, fine and microbiologically derived particulate matter related to cardiovascular and respiratory effects in a panel of elderly urban citizens', International Journal of Environmental Research and Public Health, vol. 12, no. 2, pp. 1667-1686. https://doi.org/10.3390/ijerph120201667

APA

Karottki, D. G., Spilak, M., Frederiksen, M., Andersen, Z. J., Madsen, A. M., Ketzel, M., ... Loft, S. (2015). Indoor and outdoor exposure to ultrafine, fine and microbiologically derived particulate matter related to cardiovascular and respiratory effects in a panel of elderly urban citizens. International Journal of Environmental Research and Public Health, 12(2), 1667-1686. https://doi.org/10.3390/ijerph120201667

Vancouver

Karottki DG, Spilak M, Frederiksen M, Andersen ZJ, Madsen AM, Ketzel M et al. Indoor and outdoor exposure to ultrafine, fine and microbiologically derived particulate matter related to cardiovascular and respiratory effects in a panel of elderly urban citizens. International Journal of Environmental Research and Public Health. 2015 Feb 2;12(2):1667-1686. https://doi.org/10.3390/ijerph120201667

Author

Karottki, Dorina Gabriela ; Spilak, Michal ; Frederiksen, Marie ; Andersen, Zorana Jovanovic ; Madsen, Anne Mette ; Ketzel, Matthias ; Massling, Andreas ; Gunnarsen, Lars ; Møller, Peter ; Loft, Steffen. / Indoor and outdoor exposure to ultrafine, fine and microbiologically derived particulate matter related to cardiovascular and respiratory effects in a panel of elderly urban citizens. In: International Journal of Environmental Research and Public Health. 2015 ; Vol. 12, No. 2. pp. 1667-1686.

Bibtex

@article{5661645da59241b8a3f11683c4d51d0b,
title = "Indoor and outdoor exposure to ultrafine, fine and microbiologically derived particulate matter related to cardiovascular and respiratory effects in a panel of elderly urban citizens",
abstract = "To explore associations of exposure to ambient and indoor air particulate and bio-aerosol pollutants with cardiovascular and respiratory disease markers, we utilized seven repeated measurements from 48 elderly subjects participating in a 4-week home air filtration study. Microvascular function (MVF), lung function, blood leukocyte counts, monocyte adhesion molecule expression, C-reactive protein, Clara cell protein (CC16) and surfactant protein-D (SPD) were examined in relation to exposure preceding each measurement. Exposure assessment included 48-h urban background monitoring of PM10, PM2.5 and particle number concentration (PNC), weekly measurements of PM2.5 in living- and bedroom, 24-h measurements of indoor PNC three times, and bio-aerosol components in settled dust on a 2-week basis. Statistically significant inverse associations included: MVF with outdoor PNC; granulocyte counts with PM2.5; CD31 expression with dust fungi; SPD with dust endotoxin. Significant positive associations included: MVF with dust bacteria; monocyte expression of CD11 with PM2.5 in the bedroom and dust bacteria and endotoxin, CD31 expression with dust serine protease; serum CC16 with dust NAGase. Multiple comparisons demand cautious interpretation of results, which suggest that outdoor PNC have adverse effects on MVF, and outdoor and indoor PM2.5 and bio-aerosols are associated with markers of inflammation and lung cell integrity.",
author = "Karottki, {Dorina Gabriela} and Michal Spilak and Marie Frederiksen and Andersen, {Zorana Jovanovic} and Madsen, {Anne Mette} and Matthias Ketzel and Andreas Massling and Lars Gunnarsen and Peter M{\o}ller and Steffen Loft",
year = "2015",
month = "2",
day = "2",
doi = "10.3390/ijerph120201667",
language = "English",
volume = "12",
pages = "1667--1686",
journal = "International Journal of Environmental Research and Public Health",
issn = "1661-7827",
publisher = "MDPI AG",
number = "2",

}

RIS

TY - JOUR

T1 - Indoor and outdoor exposure to ultrafine, fine and microbiologically derived particulate matter related to cardiovascular and respiratory effects in a panel of elderly urban citizens

AU - Karottki, Dorina Gabriela

AU - Spilak, Michal

AU - Frederiksen, Marie

AU - Andersen, Zorana Jovanovic

AU - Madsen, Anne Mette

AU - Ketzel, Matthias

AU - Massling, Andreas

AU - Gunnarsen, Lars

AU - Møller, Peter

AU - Loft, Steffen

PY - 2015/2/2

Y1 - 2015/2/2

N2 - To explore associations of exposure to ambient and indoor air particulate and bio-aerosol pollutants with cardiovascular and respiratory disease markers, we utilized seven repeated measurements from 48 elderly subjects participating in a 4-week home air filtration study. Microvascular function (MVF), lung function, blood leukocyte counts, monocyte adhesion molecule expression, C-reactive protein, Clara cell protein (CC16) and surfactant protein-D (SPD) were examined in relation to exposure preceding each measurement. Exposure assessment included 48-h urban background monitoring of PM10, PM2.5 and particle number concentration (PNC), weekly measurements of PM2.5 in living- and bedroom, 24-h measurements of indoor PNC three times, and bio-aerosol components in settled dust on a 2-week basis. Statistically significant inverse associations included: MVF with outdoor PNC; granulocyte counts with PM2.5; CD31 expression with dust fungi; SPD with dust endotoxin. Significant positive associations included: MVF with dust bacteria; monocyte expression of CD11 with PM2.5 in the bedroom and dust bacteria and endotoxin, CD31 expression with dust serine protease; serum CC16 with dust NAGase. Multiple comparisons demand cautious interpretation of results, which suggest that outdoor PNC have adverse effects on MVF, and outdoor and indoor PM2.5 and bio-aerosols are associated with markers of inflammation and lung cell integrity.

AB - To explore associations of exposure to ambient and indoor air particulate and bio-aerosol pollutants with cardiovascular and respiratory disease markers, we utilized seven repeated measurements from 48 elderly subjects participating in a 4-week home air filtration study. Microvascular function (MVF), lung function, blood leukocyte counts, monocyte adhesion molecule expression, C-reactive protein, Clara cell protein (CC16) and surfactant protein-D (SPD) were examined in relation to exposure preceding each measurement. Exposure assessment included 48-h urban background monitoring of PM10, PM2.5 and particle number concentration (PNC), weekly measurements of PM2.5 in living- and bedroom, 24-h measurements of indoor PNC three times, and bio-aerosol components in settled dust on a 2-week basis. Statistically significant inverse associations included: MVF with outdoor PNC; granulocyte counts with PM2.5; CD31 expression with dust fungi; SPD with dust endotoxin. Significant positive associations included: MVF with dust bacteria; monocyte expression of CD11 with PM2.5 in the bedroom and dust bacteria and endotoxin, CD31 expression with dust serine protease; serum CC16 with dust NAGase. Multiple comparisons demand cautious interpretation of results, which suggest that outdoor PNC have adverse effects on MVF, and outdoor and indoor PM2.5 and bio-aerosols are associated with markers of inflammation and lung cell integrity.

U2 - 10.3390/ijerph120201667

DO - 10.3390/ijerph120201667

M3 - Journal article

C2 - 25648225

VL - 12

SP - 1667

EP - 1686

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

SN - 1661-7827

IS - 2

ER -

ID: 132417797