Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality. / Brokken, L J S; Lundberg, P J; Spanò, M; Manicardi, G C; Pedersen, H S; Struciński, P; Góralczyk, K; Zviezdai, V; Jönsson, B A G; Bonde, J P; Toft, G; Lundberg Giwercman, Y; Giwercman, A.

In: Reproductive Toxicology, Vol. 49, 2014, p. 65-73.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Brokken, LJS, Lundberg, PJ, Spanò, M, Manicardi, GC, Pedersen, HS, Struciński, P, Góralczyk, K, Zviezdai, V, Jönsson, BAG, Bonde, JP, Toft, G, Lundberg Giwercman, Y & Giwercman, A 2014, 'Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality', Reproductive Toxicology, vol. 49, pp. 65-73. https://doi.org/10.1016/j.reprotox.2014.07.073

APA

Brokken, L. J. S., Lundberg, P. J., Spanò, M., Manicardi, G. C., Pedersen, H. S., Struciński, P., Góralczyk, K., Zviezdai, V., Jönsson, B. A. G., Bonde, J. P., Toft, G., Lundberg Giwercman, Y., & Giwercman, A. (2014). Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality. Reproductive Toxicology, 49, 65-73. https://doi.org/10.1016/j.reprotox.2014.07.073

Vancouver

Brokken LJS, Lundberg PJ, Spanò M, Manicardi GC, Pedersen HS, Struciński P et al. Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality. Reproductive Toxicology. 2014;49:65-73. https://doi.org/10.1016/j.reprotox.2014.07.073

Author

Brokken, L J S ; Lundberg, P J ; Spanò, M ; Manicardi, G C ; Pedersen, H S ; Struciński, P ; Góralczyk, K ; Zviezdai, V ; Jönsson, B A G ; Bonde, J P ; Toft, G ; Lundberg Giwercman, Y ; Giwercman, A. / Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality. In: Reproductive Toxicology. 2014 ; Vol. 49. pp. 65-73.

Bibtex

@article{043ad63995484707967e3579f977a20d,
title = "Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality",
abstract = "Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene-environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHRR P185A) and serum levels of markers of POP exposure 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE) and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) are associated with 21 parameters of male reproductive function in 581 proven-fertile European and Greenlandic men. In Greenlandic men, AHR variants significantly modified the association between serum levels of both p,p'-DDE and CB-153 and inhibin B levels, sperm chromatin integrity, and seminal zinc levels. In the total cohort, interactions between AHRR variants and serum levels of CB-153 were associated with sperm chromatin integrity and the expression of the pro-apoptotic marker protein Fas. The data indicate that susceptibility to adverse effects of POP exposure on male reproductive function is dependent on polymorphisms in genes involved in AHR signalling.",
author = "Brokken, {L J S} and Lundberg, {P J} and M Span{\`o} and Manicardi, {G C} and Pedersen, {H S} and P Struci{\'n}ski and K G{\'o}ralczyk and V Zviezdai and J{\"o}nsson, {B A G} and Bonde, {J P} and G Toft and {Lundberg Giwercman}, Y and A Giwercman",
note = "Copyright {\textcopyright} 2014 Elsevier Inc. All rights reserved.",
year = "2014",
doi = "10.1016/j.reprotox.2014.07.073",
language = "English",
volume = "49",
pages = "65--73",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality

AU - Brokken, L J S

AU - Lundberg, P J

AU - Spanò, M

AU - Manicardi, G C

AU - Pedersen, H S

AU - Struciński, P

AU - Góralczyk, K

AU - Zviezdai, V

AU - Jönsson, B A G

AU - Bonde, J P

AU - Toft, G

AU - Lundberg Giwercman, Y

AU - Giwercman, A

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2014

Y1 - 2014

N2 - Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene-environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHRR P185A) and serum levels of markers of POP exposure 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE) and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) are associated with 21 parameters of male reproductive function in 581 proven-fertile European and Greenlandic men. In Greenlandic men, AHR variants significantly modified the association between serum levels of both p,p'-DDE and CB-153 and inhibin B levels, sperm chromatin integrity, and seminal zinc levels. In the total cohort, interactions between AHRR variants and serum levels of CB-153 were associated with sperm chromatin integrity and the expression of the pro-apoptotic marker protein Fas. The data indicate that susceptibility to adverse effects of POP exposure on male reproductive function is dependent on polymorphisms in genes involved in AHR signalling.

AB - Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene-environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHRR P185A) and serum levels of markers of POP exposure 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE) and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) are associated with 21 parameters of male reproductive function in 581 proven-fertile European and Greenlandic men. In Greenlandic men, AHR variants significantly modified the association between serum levels of both p,p'-DDE and CB-153 and inhibin B levels, sperm chromatin integrity, and seminal zinc levels. In the total cohort, interactions between AHRR variants and serum levels of CB-153 were associated with sperm chromatin integrity and the expression of the pro-apoptotic marker protein Fas. The data indicate that susceptibility to adverse effects of POP exposure on male reproductive function is dependent on polymorphisms in genes involved in AHR signalling.

U2 - 10.1016/j.reprotox.2014.07.073

DO - 10.1016/j.reprotox.2014.07.073

M3 - Journal article

C2 - 25084496

VL - 49

SP - 65

EP - 73

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

ER -

ID: 137677093