Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors. / Petersen, Gitte; Sørensen, Camilla; Schmid, Patricia C; Artmann, Andreas; Tang-Christensen, Mads; Hansen, Steen H; Larsen, Philip Just; Schmid, Harald H O; Hansen, Harald S.

In: BBA General Subjects, Vol. 1761, No. 2, 02.2006, p. 143-50; discussion 141-2.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Petersen, G, Sørensen, C, Schmid, PC, Artmann, A, Tang-Christensen, M, Hansen, SH, Larsen, PJ, Schmid, HHO & Hansen, HS 2006, 'Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors', BBA General Subjects, vol. 1761, no. 2, pp. 143-50; discussion 141-2. https://doi.org/10.1016/j.bbalip.2005.12.011

APA

Petersen, G., Sørensen, C., Schmid, P. C., Artmann, A., Tang-Christensen, M., Hansen, S. H., Larsen, P. J., Schmid, H. H. O., & Hansen, H. S. (2006). Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors. BBA General Subjects, 1761(2), 143-50; discussion 141-2. https://doi.org/10.1016/j.bbalip.2005.12.011

Vancouver

Petersen G, Sørensen C, Schmid PC, Artmann A, Tang-Christensen M, Hansen SH et al. Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors. BBA General Subjects. 2006 Feb;1761(2):143-50; discussion 141-2. https://doi.org/10.1016/j.bbalip.2005.12.011

Author

Petersen, Gitte ; Sørensen, Camilla ; Schmid, Patricia C ; Artmann, Andreas ; Tang-Christensen, Mads ; Hansen, Steen H ; Larsen, Philip Just ; Schmid, Harald H O ; Hansen, Harald S. / Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors. In: BBA General Subjects. 2006 ; Vol. 1761, No. 2. pp. 143-50; discussion 141-2.

Bibtex

@article{55924ef18c91449caa582609102f5832,
title = "Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors",
abstract = "The anorectic lipid oleoylethanolamide and the orexigenic lipid anandamide both belong to the group of N-acylethanolamines that are generated by the enzyme N-acylphosphatidylethanolamine-hydrolyzing phospholipase D. The levels of the two bioactive lipids were investigated in rat intestines after 24 h of starvation as well as after 1 and 4 h of re-feeding. Total levels of precursor phospholipids and N-acylethanolamines were decreased upon food-deprivation whereas the level of the anandamide precursor molecule was significantly increased. The level of 2-arachidonoyl-glycerol was unchanged as was the activity of N-acyltransferase, N-acylphosphatidylethanolamine-hydrolyzing phospholipase D, and fatty acid amide hydrolase upon starvation and re-feeding. It is concluded that remodeling of the amide-linked fatty acids of N-acylphosphatidylethanolamine is responsible for the opposite effects on levels of anandamide and oleoylethanolamide in intestines of food-deprived rats and not an alternative biochemical route for anandamide synthesis. Furthermore, linoleoylethanolamide, which accounted for more than 50 mol% of the endogenous pool of N-acylethanolamines, was found not to have the same inhibitory effect on food intake, as did oleoylethanolamide following oral administration.",
keywords = "Animals, Arachidonic Acids, Eating, Endocannabinoids, Food Deprivation, Intestines, Male, Oleic Acids, Phospholipids, Polyunsaturated Alkamides, Rats, Rats, Sprague-Dawley, Appetite Regulation, Former Faculty of Pharmaceutical Sciences",
author = "Gitte Petersen and Camilla S{\o}rensen and Schmid, {Patricia C} and Andreas Artmann and Mads Tang-Christensen and Hansen, {Steen H} and Larsen, {Philip Just} and Schmid, {Harald H O} and Hansen, {Harald S.}",
year = "2006",
month = feb,
doi = "10.1016/j.bbalip.2005.12.011",
language = "English",
volume = "1761",
pages = "143--50; discussion 141--2",
journal = "B B A - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors

AU - Petersen, Gitte

AU - Sørensen, Camilla

AU - Schmid, Patricia C

AU - Artmann, Andreas

AU - Tang-Christensen, Mads

AU - Hansen, Steen H

AU - Larsen, Philip Just

AU - Schmid, Harald H O

AU - Hansen, Harald S.

PY - 2006/2

Y1 - 2006/2

N2 - The anorectic lipid oleoylethanolamide and the orexigenic lipid anandamide both belong to the group of N-acylethanolamines that are generated by the enzyme N-acylphosphatidylethanolamine-hydrolyzing phospholipase D. The levels of the two bioactive lipids were investigated in rat intestines after 24 h of starvation as well as after 1 and 4 h of re-feeding. Total levels of precursor phospholipids and N-acylethanolamines were decreased upon food-deprivation whereas the level of the anandamide precursor molecule was significantly increased. The level of 2-arachidonoyl-glycerol was unchanged as was the activity of N-acyltransferase, N-acylphosphatidylethanolamine-hydrolyzing phospholipase D, and fatty acid amide hydrolase upon starvation and re-feeding. It is concluded that remodeling of the amide-linked fatty acids of N-acylphosphatidylethanolamine is responsible for the opposite effects on levels of anandamide and oleoylethanolamide in intestines of food-deprived rats and not an alternative biochemical route for anandamide synthesis. Furthermore, linoleoylethanolamide, which accounted for more than 50 mol% of the endogenous pool of N-acylethanolamines, was found not to have the same inhibitory effect on food intake, as did oleoylethanolamide following oral administration.

AB - The anorectic lipid oleoylethanolamide and the orexigenic lipid anandamide both belong to the group of N-acylethanolamines that are generated by the enzyme N-acylphosphatidylethanolamine-hydrolyzing phospholipase D. The levels of the two bioactive lipids were investigated in rat intestines after 24 h of starvation as well as after 1 and 4 h of re-feeding. Total levels of precursor phospholipids and N-acylethanolamines were decreased upon food-deprivation whereas the level of the anandamide precursor molecule was significantly increased. The level of 2-arachidonoyl-glycerol was unchanged as was the activity of N-acyltransferase, N-acylphosphatidylethanolamine-hydrolyzing phospholipase D, and fatty acid amide hydrolase upon starvation and re-feeding. It is concluded that remodeling of the amide-linked fatty acids of N-acylphosphatidylethanolamine is responsible for the opposite effects on levels of anandamide and oleoylethanolamide in intestines of food-deprived rats and not an alternative biochemical route for anandamide synthesis. Furthermore, linoleoylethanolamide, which accounted for more than 50 mol% of the endogenous pool of N-acylethanolamines, was found not to have the same inhibitory effect on food intake, as did oleoylethanolamide following oral administration.

KW - Animals

KW - Arachidonic Acids

KW - Eating

KW - Endocannabinoids

KW - Food Deprivation

KW - Intestines

KW - Male

KW - Oleic Acids

KW - Phospholipids

KW - Polyunsaturated Alkamides

KW - Rats

KW - Rats, Sprague-Dawley

KW - Appetite Regulation

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.bbalip.2005.12.011

DO - 10.1016/j.bbalip.2005.12.011

M3 - Journal article

C2 - 16478679

VL - 1761

SP - 143-50; discussion 141-2

JO - B B A - General Subjects

JF - B B A - General Subjects

SN - 0304-4165

IS - 2

ER -

ID: 44796934