Longitudinal changes in C-reactive protein, proform of eosinophil major basic protein, and pregnancy-associated plasma protein-A during weight changes in obese children

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Longitudinal changes in C-reactive protein, proform of eosinophil major basic protein, and pregnancy-associated plasma protein-A during weight changes in obese children. / Lausten-Thomsen, Ulrik; Gamborg, Michael; Bøjsøe, Christine; Hedley, Paula L; Hagen, Christian Munch; Christiansen, Michael; Holm, Jens-Christian.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 28, No. 3-4, 03.2015, p. 393-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lausten-Thomsen, U, Gamborg, M, Bøjsøe, C, Hedley, PL, Hagen, CM, Christiansen, M & Holm, J-C 2015, 'Longitudinal changes in C-reactive protein, proform of eosinophil major basic protein, and pregnancy-associated plasma protein-A during weight changes in obese children', Journal of Pediatric Endocrinology and Metabolism, vol. 28, no. 3-4, pp. 393-8. https://doi.org/10.1515/jpem-2014-0249

APA

Lausten-Thomsen, U., Gamborg, M., Bøjsøe, C., Hedley, P. L., Hagen, C. M., Christiansen, M., & Holm, J-C. (2015). Longitudinal changes in C-reactive protein, proform of eosinophil major basic protein, and pregnancy-associated plasma protein-A during weight changes in obese children. Journal of Pediatric Endocrinology and Metabolism, 28(3-4), 393-8. https://doi.org/10.1515/jpem-2014-0249

Vancouver

Lausten-Thomsen U, Gamborg M, Bøjsøe C, Hedley PL, Hagen CM, Christiansen M et al. Longitudinal changes in C-reactive protein, proform of eosinophil major basic protein, and pregnancy-associated plasma protein-A during weight changes in obese children. Journal of Pediatric Endocrinology and Metabolism. 2015 Mar;28(3-4):393-8. https://doi.org/10.1515/jpem-2014-0249

Author

Lausten-Thomsen, Ulrik ; Gamborg, Michael ; Bøjsøe, Christine ; Hedley, Paula L ; Hagen, Christian Munch ; Christiansen, Michael ; Holm, Jens-Christian. / Longitudinal changes in C-reactive protein, proform of eosinophil major basic protein, and pregnancy-associated plasma protein-A during weight changes in obese children. In: Journal of Pediatric Endocrinology and Metabolism. 2015 ; Vol. 28, No. 3-4. pp. 393-8.

Bibtex

@article{00ed0689e7bf4a6fa2e835ae6c0a4e40,
title = "Longitudinal changes in C-reactive protein, proform of eosinophil major basic protein, and pregnancy-associated plasma protein-A during weight changes in obese children",
abstract = "BACKGROUND: Childhood obesity is associated with several complications, including cardiovascular comorbidity. Several biomarkers, such as high-sensitive C-reactive protein (hs-CRP), proform of eosinophil major basic protein (Pro-MBP) and pregnancy associated plasma protein-A (PAPP-A), have equally been linked to increased cardiovascular susceptibility. This study investigates these biomarkers during weight loss and regain in obese children.MATERIALS AND METHODS: A longitudinal study during a 12-week weight loss program with a 28 months follow-up was conducted. Anthropometrics and plasma concentrations of hs-CRP, Pro-MBP, and PAPP-A were measured at baseline; at days 14, 33 and 82 during weight loss; and at months 10, 16, and 28 during follow-up.RESULTS: Fifty-three boys and 62 girls aged 8-15 years with a median body mass index (BMI) standard deviation score (SDS) at baseline of 2.78 (boys), and 2.70 (girls) were included. Ninety children completed the weight loss program and 68 children entered the follow-up program. Pro-MBP and PAPP-A, but not hs-CRP, exhibited individual-specific levels (tracking) during weight loss and regain. The PAPP-A/Pro-MBP correlation was strong, whereas the hs-CRP/PAPP-A correlation was weak during weight fluctuations.CONCLUSION: Hs-CRP changes reflect weight changes. PAPP-A and Pro-MBP exhibited tracking during weight perturbations and may contribute as early risk markers of cardiovascular susceptibility.",
author = "Ulrik Lausten-Thomsen and Michael Gamborg and Christine B{\o}js{\o}e and Hedley, {Paula L} and Hagen, {Christian Munch} and Michael Christiansen and Jens-Christian Holm",
year = "2015",
month = mar,
doi = "10.1515/jpem-2014-0249",
language = "English",
volume = "28",
pages = "393--8",
journal = "Journal of Pediatric Endocrinology and Metabolism",
issn = "0334-018X",
publisher = "Walterde Gruyter GmbH",
number = "3-4",

}

RIS

TY - JOUR

T1 - Longitudinal changes in C-reactive protein, proform of eosinophil major basic protein, and pregnancy-associated plasma protein-A during weight changes in obese children

AU - Lausten-Thomsen, Ulrik

AU - Gamborg, Michael

AU - Bøjsøe, Christine

AU - Hedley, Paula L

AU - Hagen, Christian Munch

AU - Christiansen, Michael

AU - Holm, Jens-Christian

PY - 2015/3

Y1 - 2015/3

N2 - BACKGROUND: Childhood obesity is associated with several complications, including cardiovascular comorbidity. Several biomarkers, such as high-sensitive C-reactive protein (hs-CRP), proform of eosinophil major basic protein (Pro-MBP) and pregnancy associated plasma protein-A (PAPP-A), have equally been linked to increased cardiovascular susceptibility. This study investigates these biomarkers during weight loss and regain in obese children.MATERIALS AND METHODS: A longitudinal study during a 12-week weight loss program with a 28 months follow-up was conducted. Anthropometrics and plasma concentrations of hs-CRP, Pro-MBP, and PAPP-A were measured at baseline; at days 14, 33 and 82 during weight loss; and at months 10, 16, and 28 during follow-up.RESULTS: Fifty-three boys and 62 girls aged 8-15 years with a median body mass index (BMI) standard deviation score (SDS) at baseline of 2.78 (boys), and 2.70 (girls) were included. Ninety children completed the weight loss program and 68 children entered the follow-up program. Pro-MBP and PAPP-A, but not hs-CRP, exhibited individual-specific levels (tracking) during weight loss and regain. The PAPP-A/Pro-MBP correlation was strong, whereas the hs-CRP/PAPP-A correlation was weak during weight fluctuations.CONCLUSION: Hs-CRP changes reflect weight changes. PAPP-A and Pro-MBP exhibited tracking during weight perturbations and may contribute as early risk markers of cardiovascular susceptibility.

AB - BACKGROUND: Childhood obesity is associated with several complications, including cardiovascular comorbidity. Several biomarkers, such as high-sensitive C-reactive protein (hs-CRP), proform of eosinophil major basic protein (Pro-MBP) and pregnancy associated plasma protein-A (PAPP-A), have equally been linked to increased cardiovascular susceptibility. This study investigates these biomarkers during weight loss and regain in obese children.MATERIALS AND METHODS: A longitudinal study during a 12-week weight loss program with a 28 months follow-up was conducted. Anthropometrics and plasma concentrations of hs-CRP, Pro-MBP, and PAPP-A were measured at baseline; at days 14, 33 and 82 during weight loss; and at months 10, 16, and 28 during follow-up.RESULTS: Fifty-three boys and 62 girls aged 8-15 years with a median body mass index (BMI) standard deviation score (SDS) at baseline of 2.78 (boys), and 2.70 (girls) were included. Ninety children completed the weight loss program and 68 children entered the follow-up program. Pro-MBP and PAPP-A, but not hs-CRP, exhibited individual-specific levels (tracking) during weight loss and regain. The PAPP-A/Pro-MBP correlation was strong, whereas the hs-CRP/PAPP-A correlation was weak during weight fluctuations.CONCLUSION: Hs-CRP changes reflect weight changes. PAPP-A and Pro-MBP exhibited tracking during weight perturbations and may contribute as early risk markers of cardiovascular susceptibility.

U2 - 10.1515/jpem-2014-0249

DO - 10.1515/jpem-2014-0249

M3 - Journal article

C2 - 25460282

VL - 28

SP - 393

EP - 398

JO - Journal of Pediatric Endocrinology and Metabolism

JF - Journal of Pediatric Endocrinology and Metabolism

SN - 0334-018X

IS - 3-4

ER -

ID: 137325361