Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts
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Long-term air pollution exposure and malignant intracranial tumours of the central nervous system : a pooled analysis of six European cohorts. / Hvidtfeldt, Ulla Arthur; Chen, Jie; Rodopoulou, Sophia; Strak, Maciej; de Hoogh, Kees; Andersen, Zorana J.; Bellander, Tom; Brandt, Jørgen; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara; Katsouyanni, Klea; Ketzel, Matthias; Leander, Karin; Magnusson, Patrik K.E.; Nagel, Gabriele; Pershagen, Göran; Rizzuto, Debora; Samoli, Evangelia; So, Rina; Stafoggia, Massimo; Tjønneland, Anne; Weinmayr, Gudrun; Wolf, Kathrin; Zhang, Jiawei; Zitt, Emanuel; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole.
In: British Journal of Cancer, Vol. 129, 2023, p. 656–664.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Long-term air pollution exposure and malignant intracranial tumours of the central nervous system
T2 - a pooled analysis of six European cohorts
AU - Hvidtfeldt, Ulla Arthur
AU - Chen, Jie
AU - Rodopoulou, Sophia
AU - Strak, Maciej
AU - de Hoogh, Kees
AU - Andersen, Zorana J.
AU - Bellander, Tom
AU - Brandt, Jørgen
AU - Fecht, Daniela
AU - Forastiere, Francesco
AU - Gulliver, John
AU - Hertel, Ole
AU - Hoffmann, Barbara
AU - Katsouyanni, Klea
AU - Ketzel, Matthias
AU - Leander, Karin
AU - Magnusson, Patrik K.E.
AU - Nagel, Gabriele
AU - Pershagen, Göran
AU - Rizzuto, Debora
AU - Samoli, Evangelia
AU - So, Rina
AU - Stafoggia, Massimo
AU - Tjønneland, Anne
AU - Weinmayr, Gudrun
AU - Wolf, Kathrin
AU - Zhang, Jiawei
AU - Zitt, Emanuel
AU - Brunekreef, Bert
AU - Hoek, Gerard
AU - Raaschou-Nielsen, Ole
N1 - Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2023
Y1 - 2023
N2 - Background: Risk factors for malignant tumours of the central nervous system (CNS) are largely unknown. Methods: We pooled six European cohorts (N = 302,493) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) and malignant intracranial CNS tumours defined according to the International Classification of Diseases ICD-9/ICD-10 codes 192.1/C70.0, 191.0–191.9/C71.0–C71.9, 192.0/C72.2–C72.5. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. Results: During 5,497,514 person-years of follow-up (average 18.2 years), we observed 623 malignant CNS tumours. The results of the fully adjusted linear analyses showed a hazard ratio (95% confidence interval) of 1.07 (0.95, 1.21) per 10 μg/m³ NO2, 1.17 (0.96, 1.41) per 5 μg/m³ PM2.5, 1.10 (0.97, 1.25) per 0.5 10−5m−1 BC, and 0.99 (0.84, 1.17) per 10 μg/m³ O3. Conclusions: We observed indications of an association between exposure to NO2, PM2.5, and BC and tumours of the CNS. The PM elements were not consistently associated with CNS tumour incidence.
AB - Background: Risk factors for malignant tumours of the central nervous system (CNS) are largely unknown. Methods: We pooled six European cohorts (N = 302,493) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) and malignant intracranial CNS tumours defined according to the International Classification of Diseases ICD-9/ICD-10 codes 192.1/C70.0, 191.0–191.9/C71.0–C71.9, 192.0/C72.2–C72.5. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. Results: During 5,497,514 person-years of follow-up (average 18.2 years), we observed 623 malignant CNS tumours. The results of the fully adjusted linear analyses showed a hazard ratio (95% confidence interval) of 1.07 (0.95, 1.21) per 10 μg/m³ NO2, 1.17 (0.96, 1.41) per 5 μg/m³ PM2.5, 1.10 (0.97, 1.25) per 0.5 10−5m−1 BC, and 0.99 (0.84, 1.17) per 10 μg/m³ O3. Conclusions: We observed indications of an association between exposure to NO2, PM2.5, and BC and tumours of the CNS. The PM elements were not consistently associated with CNS tumour incidence.
U2 - 10.1038/s41416-023-02348-1
DO - 10.1038/s41416-023-02348-1
M3 - Journal article
C2 - 37420001
AN - SCOPUS:85164186719
VL - 129
SP - 656
EP - 664
JO - The British journal of cancer. Supplement
JF - The British journal of cancer. Supplement
SN - 0007-0920
ER -
ID: 360769527