Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts

Research output: Contribution to journal › Journal article › Research › peer-review

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Long-term air pollution exposure and malignant intracranial tumours of the central nervous system : a pooled analysis of six European cohorts. / Hvidtfeldt, Ulla Arthur; Chen, Jie; Rodopoulou, Sophia; Strak, Maciej; de Hoogh, Kees; Andersen, Zorana J.; Bellander, Tom; Brandt, Jørgen; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara; Katsouyanni, Klea; Ketzel, Matthias; Leander, Karin; Magnusson, Patrik K.E.; Nagel, Gabriele; Pershagen, Göran; Rizzuto, Debora; Samoli, Evangelia; So, Rina; Stafoggia, Massimo; Tjønneland, Anne; Weinmayr, Gudrun; Wolf, Kathrin; Zhang, Jiawei; Zitt, Emanuel; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole.

In: British Journal of Cancer, Vol. 129, 2023, p. 656–664.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hvidtfeldt, UA, Chen, J, Rodopoulou, S, Strak, M, de Hoogh, K, Andersen, ZJ, Bellander, T, Brandt, J, Fecht, D, Forastiere, F, Gulliver, J, Hertel, O, Hoffmann, B, Katsouyanni, K, Ketzel, M, Leander, K, Magnusson, PKE, Nagel, G, Pershagen, G, Rizzuto, D, Samoli, E, So, R, Stafoggia, M, Tjønneland, A, Weinmayr, G, Wolf, K, Zhang, J, Zitt, E, Brunekreef, B, Hoek, G & Raaschou-Nielsen, O 2023, 'Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts', British Journal of Cancer, vol. 129, pp. 656–664. https://doi.org/10.1038/s41416-023-02348-1

APA

Hvidtfeldt, U. A., Chen, J., Rodopoulou, S., Strak, M., de Hoogh, K., Andersen, Z. J., Bellander, T., Brandt, J., Fecht, D., Forastiere, F., Gulliver, J., Hertel, O., Hoffmann, B., Katsouyanni, K., Ketzel, M., Leander, K., Magnusson, P. K. E., Nagel, G., Pershagen, G., ... Raaschou-Nielsen, O. (2023). Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts. British Journal of Cancer, 129, 656–664. https://doi.org/10.1038/s41416-023-02348-1

Vancouver

Hvidtfeldt UA, Chen J, Rodopoulou S, Strak M, de Hoogh K, Andersen ZJ et al. Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts. British Journal of Cancer. 2023;129:656–664. https://doi.org/10.1038/s41416-023-02348-1

Author

Hvidtfeldt, Ulla Arthur ; Chen, Jie ; Rodopoulou, Sophia ; Strak, Maciej ; de Hoogh, Kees ; Andersen, Zorana J. ; Bellander, Tom ; Brandt, Jørgen ; Fecht, Daniela ; Forastiere, Francesco ; Gulliver, John ; Hertel, Ole ; Hoffmann, Barbara ; Katsouyanni, Klea ; Ketzel, Matthias ; Leander, Karin ; Magnusson, Patrik K.E. ; Nagel, Gabriele ; Pershagen, Göran ; Rizzuto, Debora ; Samoli, Evangelia ; So, Rina ; Stafoggia, Massimo ; Tjønneland, Anne ; Weinmayr, Gudrun ; Wolf, Kathrin ; Zhang, Jiawei ; Zitt, Emanuel ; Brunekreef, Bert ; Hoek, Gerard ; Raaschou-Nielsen, Ole. / Long-term air pollution exposure and malignant intracranial tumours of the central nervous system : a pooled analysis of six European cohorts. In: British Journal of Cancer. 2023 ; Vol. 129. pp. 656–664.

Bibtex

@article{0057cb28423144da8f19cef9a18b4fdc,
title = "Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts",
abstract = "Background: Risk factors for malignant tumours of the central nervous system (CNS) are largely unknown. Methods: We pooled six European cohorts (N = 302,493) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) and malignant intracranial CNS tumours defined according to the International Classification of Diseases ICD-9/ICD-10 codes 192.1/C70.0, 191.0–191.9/C71.0–C71.9, 192.0/C72.2–C72.5. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. Results: During 5,497,514 person-years of follow-up (average 18.2 years), we observed 623 malignant CNS tumours. The results of the fully adjusted linear analyses showed a hazard ratio (95% confidence interval) of 1.07 (0.95, 1.21) per 10 μg/m³ NO2, 1.17 (0.96, 1.41) per 5 μg/m³ PM2.5, 1.10 (0.97, 1.25) per 0.5 10−5m−1 BC, and 0.99 (0.84, 1.17) per 10 μg/m³ O3. Conclusions: We observed indications of an association between exposure to NO2, PM2.5, and BC and tumours of the CNS. The PM elements were not consistently associated with CNS tumour incidence.",
author = "Hvidtfeldt, {Ulla Arthur} and Jie Chen and Sophia Rodopoulou and Maciej Strak and {de Hoogh}, Kees and Andersen, {Zorana J.} and Tom Bellander and J{\o}rgen Brandt and Daniela Fecht and Francesco Forastiere and John Gulliver and Ole Hertel and Barbara Hoffmann and Klea Katsouyanni and Matthias Ketzel and Karin Leander and Magnusson, {Patrik K.E.} and Gabriele Nagel and G{\"o}ran Pershagen and Debora Rizzuto and Evangelia Samoli and Rina So and Massimo Stafoggia and Anne Tj{\o}nneland and Gudrun Weinmayr and Kathrin Wolf and Jiawei Zhang and Emanuel Zitt and Bert Brunekreef and Gerard Hoek and Ole Raaschou-Nielsen",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature Limited.",
year = "2023",
doi = "10.1038/s41416-023-02348-1",
language = "English",
volume = "129",
pages = "656–664",
journal = "The British journal of cancer. Supplement",
issn = "0007-0920",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Long-term air pollution exposure and malignant intracranial tumours of the central nervous system

T2 - a pooled analysis of six European cohorts

AU - Hvidtfeldt, Ulla Arthur

AU - Chen, Jie

AU - Rodopoulou, Sophia

AU - Strak, Maciej

AU - de Hoogh, Kees

AU - Andersen, Zorana J.

AU - Bellander, Tom

AU - Brandt, Jørgen

AU - Fecht, Daniela

AU - Forastiere, Francesco

AU - Gulliver, John

AU - Hertel, Ole

AU - Hoffmann, Barbara

AU - Katsouyanni, Klea

AU - Ketzel, Matthias

AU - Leander, Karin

AU - Magnusson, Patrik K.E.

AU - Nagel, Gabriele

AU - Pershagen, Göran

AU - Rizzuto, Debora

AU - Samoli, Evangelia

AU - So, Rina

AU - Stafoggia, Massimo

AU - Tjønneland, Anne

AU - Weinmayr, Gudrun

AU - Wolf, Kathrin

AU - Zhang, Jiawei

AU - Zitt, Emanuel

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Raaschou-Nielsen, Ole

N1 - Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Nature Limited.

PY - 2023

Y1 - 2023

N2 - Background: Risk factors for malignant tumours of the central nervous system (CNS) are largely unknown. Methods: We pooled six European cohorts (N = 302,493) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) and malignant intracranial CNS tumours defined according to the International Classification of Diseases ICD-9/ICD-10 codes 192.1/C70.0, 191.0–191.9/C71.0–C71.9, 192.0/C72.2–C72.5. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. Results: During 5,497,514 person-years of follow-up (average 18.2 years), we observed 623 malignant CNS tumours. The results of the fully adjusted linear analyses showed a hazard ratio (95% confidence interval) of 1.07 (0.95, 1.21) per 10 μg/m³ NO2, 1.17 (0.96, 1.41) per 5 μg/m³ PM2.5, 1.10 (0.97, 1.25) per 0.5 10−5m−1 BC, and 0.99 (0.84, 1.17) per 10 μg/m³ O3. Conclusions: We observed indications of an association between exposure to NO2, PM2.5, and BC and tumours of the CNS. The PM elements were not consistently associated with CNS tumour incidence.

AB - Background: Risk factors for malignant tumours of the central nervous system (CNS) are largely unknown. Methods: We pooled six European cohorts (N = 302,493) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) and malignant intracranial CNS tumours defined according to the International Classification of Diseases ICD-9/ICD-10 codes 192.1/C70.0, 191.0–191.9/C71.0–C71.9, 192.0/C72.2–C72.5. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. Results: During 5,497,514 person-years of follow-up (average 18.2 years), we observed 623 malignant CNS tumours. The results of the fully adjusted linear analyses showed a hazard ratio (95% confidence interval) of 1.07 (0.95, 1.21) per 10 μg/m³ NO2, 1.17 (0.96, 1.41) per 5 μg/m³ PM2.5, 1.10 (0.97, 1.25) per 0.5 10−5m−1 BC, and 0.99 (0.84, 1.17) per 10 μg/m³ O3. Conclusions: We observed indications of an association between exposure to NO2, PM2.5, and BC and tumours of the CNS. The PM elements were not consistently associated with CNS tumour incidence.

U2 - 10.1038/s41416-023-02348-1

DO - 10.1038/s41416-023-02348-1

M3 - Journal article

C2 - 37420001

AN - SCOPUS:85164186719

VL - 129

SP - 656

EP - 664

JO - The British journal of cancer. Supplement

JF - The British journal of cancer. Supplement

SN - 0007-0920

ER -

ID: 360769527