Long-term exposure to fine particle elemental components and mortality in Europe: Results from six European administrative cohorts within the ELAPSE project
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Long-term exposure to fine particle elemental components and mortality in Europe : Results from six European administrative cohorts within the ELAPSE project. / Rodopoulou, Sophia; Stafoggia, Massimo; Chen, Jie; de Hoogh, Kees; Bauwelinck, Mariska; Mehta, Amar J.; Klompmaker, Jochem O.; Oftedal, Bente; Vienneau, Danielle; Janssen, Nicole A.H.; Strak, Maciej; Andersen, Zorana J.; Renzi, Matteo; Cesaroni, Giulia; Nordheim, Carl Fredrik; Bekkevold, Terese; Atkinson, Richard; Forastiere, Francesco; Katsouyanni, Klea; Brunekreef, Bert; Samoli, Evangelia; Hoek, Gerard.
In: Science of the Total Environment, Vol. 809, 152205, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Long-term exposure to fine particle elemental components and mortality in Europe
T2 - Results from six European administrative cohorts within the ELAPSE project
AU - Rodopoulou, Sophia
AU - Stafoggia, Massimo
AU - Chen, Jie
AU - de Hoogh, Kees
AU - Bauwelinck, Mariska
AU - Mehta, Amar J.
AU - Klompmaker, Jochem O.
AU - Oftedal, Bente
AU - Vienneau, Danielle
AU - Janssen, Nicole A.H.
AU - Strak, Maciej
AU - Andersen, Zorana J.
AU - Renzi, Matteo
AU - Cesaroni, Giulia
AU - Nordheim, Carl Fredrik
AU - Bekkevold, Terese
AU - Atkinson, Richard
AU - Forastiere, Francesco
AU - Katsouyanni, Klea
AU - Brunekreef, Bert
AU - Samoli, Evangelia
AU - Hoek, Gerard
N1 - Publisher Copyright: © 2021
PY - 2022
Y1 - 2022
N2 - Evidence for the association between long-term exposure to ambient particulate matter components and mortality from natural causes is sparse and inconsistent. We evaluated this association in six large administrative cohorts in the framework of the Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE) project. We analyzed data from country-wide administrative cohorts in Norway, Denmark, the Netherlands, Belgium, Switzerland and in Rome (Italy). Annual 2010 mean concentrations of copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V) and zinc (Zn) in fine particulate matter (PM2.5) were estimated using 100 × 100 m Europe-wide hybrid land use regression models assigned to the participants' residential addresses. We applied cohort-specific Cox proportional hazard models controlling for area- and individual-level covariates to evaluate associations with natural mortality. Two pollutant models adjusting for PM2.5 total mass or nitrogen dioxide (NO2) were also applied. We pooled cohort-specific estimates using a random effects meta-analysis. We included almost 27 million participants contributing more than 240 million person-years. All components except Zn were significantly associated with natural mortality [pooled Hazard Ratios (HRs) (95% CI): 1.037 (1.014, 1.060) per 5 ng/m3 Cu; 1.069 (1.031, 1.108) per 100 ng/m3 Fe; 1.039 (1.018, 1.062) per 50 ng/m3 K; 1.024 (1.006, 1.043) per 1 ng/m3 Ni; 1.036 (1.016, 1.057) per 200 ng/m3 S; 1.152 (1.048, 1.266) per 100 ng/m3 Si; 1.020 (1.006, 1.034) per 2 ng/m3 V]. Only K and Si were robust to PM2.5 or NO2 adjustment [pooled HRs (95% CI) per 50 ng/m3 in K: 1.025 (1.008, 1.044), 1.020 (0.999, 1.042) and per 100 ng/m3 in Si: 1.121 (1.039, 1.209), 1.068 (1.022, 1.117) adjusted for PM2.5 and NO2 correspondingly]. Our findings indicate an association of natural mortality with most components, which was reduced after adjustment for PM2.5 and especially NO2.
AB - Evidence for the association between long-term exposure to ambient particulate matter components and mortality from natural causes is sparse and inconsistent. We evaluated this association in six large administrative cohorts in the framework of the Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE) project. We analyzed data from country-wide administrative cohorts in Norway, Denmark, the Netherlands, Belgium, Switzerland and in Rome (Italy). Annual 2010 mean concentrations of copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V) and zinc (Zn) in fine particulate matter (PM2.5) were estimated using 100 × 100 m Europe-wide hybrid land use regression models assigned to the participants' residential addresses. We applied cohort-specific Cox proportional hazard models controlling for area- and individual-level covariates to evaluate associations with natural mortality. Two pollutant models adjusting for PM2.5 total mass or nitrogen dioxide (NO2) were also applied. We pooled cohort-specific estimates using a random effects meta-analysis. We included almost 27 million participants contributing more than 240 million person-years. All components except Zn were significantly associated with natural mortality [pooled Hazard Ratios (HRs) (95% CI): 1.037 (1.014, 1.060) per 5 ng/m3 Cu; 1.069 (1.031, 1.108) per 100 ng/m3 Fe; 1.039 (1.018, 1.062) per 50 ng/m3 K; 1.024 (1.006, 1.043) per 1 ng/m3 Ni; 1.036 (1.016, 1.057) per 200 ng/m3 S; 1.152 (1.048, 1.266) per 100 ng/m3 Si; 1.020 (1.006, 1.034) per 2 ng/m3 V]. Only K and Si were robust to PM2.5 or NO2 adjustment [pooled HRs (95% CI) per 50 ng/m3 in K: 1.025 (1.008, 1.044), 1.020 (0.999, 1.042) and per 100 ng/m3 in Si: 1.121 (1.039, 1.209), 1.068 (1.022, 1.117) adjusted for PM2.5 and NO2 correspondingly]. Our findings indicate an association of natural mortality with most components, which was reduced after adjustment for PM2.5 and especially NO2.
KW - Air pollution
KW - Long-term exposure
KW - Natural mortality
KW - Particle components
U2 - 10.1016/j.scitotenv.2021.152205
DO - 10.1016/j.scitotenv.2021.152205
M3 - Journal article
C2 - 34890671
AN - SCOPUS:85121119528
VL - 809
JO - Science of the Total Environment
JF - Science of the Total Environment
SN - 0048-9697
M1 - 152205
ER -
ID: 288915318