Long-term exposure to several constituents and sources of PM2.5 is associated with incidence of upper aerodigestive tract cancers but not gastric cancer: Results from the large pooled European cohort of the ELAPSE project

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Long-term exposure to several constituents and sources of PM2.5 is associated with incidence of upper aerodigestive tract cancers but not gastric cancer : Results from the large pooled European cohort of the ELAPSE project. / Weinmayr, Gudrun; Chen, Jie; Jaensch, Andrea; Skodda, Lea; Rodopoulou, Sophia; Strak, Maciej; de Hoogh, Kees; Andersen, Zorana J.; Bellander, Tom; Brandt, Jørgen; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara; Hvidtfeldt, Ulla Arthur; Katsouyanni, Klea; Ketzel, Matthias; Leander, Karin; Magnusson, Patrik K.E.; Pershagen, Göran; Rizzuto, Debora; Samoli, Evangelia; Severi, Gianluca; Stafoggia, Massimo; Tjønneland, Anne; Vermeulen, Roel; Wolf, Kathrin; Zitt, Emanuel; Brunekreef, Bert; Thurston, George; Hoek, Gerard; Raaschou-Nielsen, Ole; Nagel, Gabriele.

In: Science of the Total Environment, Vol. 912, 168789, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Weinmayr, G, Chen, J, Jaensch, A, Skodda, L, Rodopoulou, S, Strak, M, de Hoogh, K, Andersen, ZJ, Bellander, T, Brandt, J, Fecht, D, Forastiere, F, Gulliver, J, Hertel, O, Hoffmann, B, Hvidtfeldt, UA, Katsouyanni, K, Ketzel, M, Leander, K, Magnusson, PKE, Pershagen, G, Rizzuto, D, Samoli, E, Severi, G, Stafoggia, M, Tjønneland, A, Vermeulen, R, Wolf, K, Zitt, E, Brunekreef, B, Thurston, G, Hoek, G, Raaschou-Nielsen, O & Nagel, G 2024, 'Long-term exposure to several constituents and sources of PM2.5 is associated with incidence of upper aerodigestive tract cancers but not gastric cancer: Results from the large pooled European cohort of the ELAPSE project', Science of the Total Environment, vol. 912, 168789. https://doi.org/10.1016/j.scitotenv.2023.168789

APA

Weinmayr, G., Chen, J., Jaensch, A., Skodda, L., Rodopoulou, S., Strak, M., de Hoogh, K., Andersen, Z. J., Bellander, T., Brandt, J., Fecht, D., Forastiere, F., Gulliver, J., Hertel, O., Hoffmann, B., Hvidtfeldt, U. A., Katsouyanni, K., Ketzel, M., Leander, K., ... Nagel, G. (2024). Long-term exposure to several constituents and sources of PM2.5 is associated with incidence of upper aerodigestive tract cancers but not gastric cancer: Results from the large pooled European cohort of the ELAPSE project. Science of the Total Environment, 912, [168789]. https://doi.org/10.1016/j.scitotenv.2023.168789

Vancouver

Weinmayr G, Chen J, Jaensch A, Skodda L, Rodopoulou S, Strak M et al. Long-term exposure to several constituents and sources of PM2.5 is associated with incidence of upper aerodigestive tract cancers but not gastric cancer: Results from the large pooled European cohort of the ELAPSE project. Science of the Total Environment. 2024;912. 168789. https://doi.org/10.1016/j.scitotenv.2023.168789

Author

Weinmayr, Gudrun ; Chen, Jie ; Jaensch, Andrea ; Skodda, Lea ; Rodopoulou, Sophia ; Strak, Maciej ; de Hoogh, Kees ; Andersen, Zorana J. ; Bellander, Tom ; Brandt, Jørgen ; Fecht, Daniela ; Forastiere, Francesco ; Gulliver, John ; Hertel, Ole ; Hoffmann, Barbara ; Hvidtfeldt, Ulla Arthur ; Katsouyanni, Klea ; Ketzel, Matthias ; Leander, Karin ; Magnusson, Patrik K.E. ; Pershagen, Göran ; Rizzuto, Debora ; Samoli, Evangelia ; Severi, Gianluca ; Stafoggia, Massimo ; Tjønneland, Anne ; Vermeulen, Roel ; Wolf, Kathrin ; Zitt, Emanuel ; Brunekreef, Bert ; Thurston, George ; Hoek, Gerard ; Raaschou-Nielsen, Ole ; Nagel, Gabriele. / Long-term exposure to several constituents and sources of PM2.5 is associated with incidence of upper aerodigestive tract cancers but not gastric cancer : Results from the large pooled European cohort of the ELAPSE project. In: Science of the Total Environment. 2024 ; Vol. 912.

Bibtex

@article{7724740035374814bd82389547559ef4,
title = "Long-term exposure to several constituents and sources of PM2.5 is associated with incidence of upper aerodigestive tract cancers but not gastric cancer: Results from the large pooled European cohort of the ELAPSE project",
abstract = "It is unclear whether cancers of the upper aerodigestive tract (UADT) and gastric cancer are related to air pollution, due to few studies with inconsistent results. The effects of particulate matter (PM) may vary across locations due to different source contributions and related PM compositions, and it is not clear which PM constituents/sources are most relevant from a consideration of overall mass concentration alone. We therefore investigated the association of UADT and gastric cancers with PM2.5 elemental constituents and sources components indicative of different sources within a large multicentre population based epidemiological study. Cohorts with at least 10 cases per cohort led to ten and eight cohorts from five countries contributing to UADT- and gastric cancer analysis, respectively. Outcome ascertainment was based on cancer registry data or data of comparable quality. We assigned home address exposure to eight elemental constituents (Cu, Fe, K, Ni, S, Si, V and Zn) estimated from Europe-wide exposure models, and five source components identified by absolute principal component analysis (APCA). Cox regression models were run with age as time scale, stratified for sex and cohort and adjusted for relevant individual and neighbourhood level confounders. We observed 1139 UADT and 872 gastric cancer cases during a mean follow-up of 18.3 and 18.5 years, respectively. UADT cancer incidence was associated with all constituents except K in single element analyses. After adjustment for NO2, only Ni and V remained associated with UADT. Residual oil combustion and traffic source components were associated with UADT cancer persisting in the multiple source model. No associations were found for any of the elements or source components and gastric cancer incidence. Our results indicate an association of several PM constituents indicative of different sources with UADT but not gastric cancer incidence with the most robust evidence for traffic and residual oil combustion.",
keywords = "Air pollution, Gastric cancer, Long-term exposure, Particulate matter (PM), PM composition, PM sources, Upper aerodigestive tract cancer",
author = "Gudrun Weinmayr and Jie Chen and Andrea Jaensch and Lea Skodda and Sophia Rodopoulou and Maciej Strak and {de Hoogh}, Kees and Andersen, {Zorana J.} and Tom Bellander and J{\o}rgen Brandt and Daniela Fecht and Francesco Forastiere and John Gulliver and Ole Hertel and Barbara Hoffmann and Hvidtfeldt, {Ulla Arthur} and Klea Katsouyanni and Matthias Ketzel and Karin Leander and Magnusson, {Patrik K.E.} and G{\"o}ran Pershagen and Debora Rizzuto and Evangelia Samoli and Gianluca Severi and Massimo Stafoggia and Anne Tj{\o}nneland and Roel Vermeulen and Kathrin Wolf and Emanuel Zitt and Bert Brunekreef and George Thurston and Gerard Hoek and Ole Raaschou-Nielsen and Gabriele Nagel",
note = "Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",
year = "2024",
doi = "10.1016/j.scitotenv.2023.168789",
language = "English",
volume = "912",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Long-term exposure to several constituents and sources of PM2.5 is associated with incidence of upper aerodigestive tract cancers but not gastric cancer

T2 - Results from the large pooled European cohort of the ELAPSE project

AU - Weinmayr, Gudrun

AU - Chen, Jie

AU - Jaensch, Andrea

AU - Skodda, Lea

AU - Rodopoulou, Sophia

AU - Strak, Maciej

AU - de Hoogh, Kees

AU - Andersen, Zorana J.

AU - Bellander, Tom

AU - Brandt, Jørgen

AU - Fecht, Daniela

AU - Forastiere, Francesco

AU - Gulliver, John

AU - Hertel, Ole

AU - Hoffmann, Barbara

AU - Hvidtfeldt, Ulla Arthur

AU - Katsouyanni, Klea

AU - Ketzel, Matthias

AU - Leander, Karin

AU - Magnusson, Patrik K.E.

AU - Pershagen, Göran

AU - Rizzuto, Debora

AU - Samoli, Evangelia

AU - Severi, Gianluca

AU - Stafoggia, Massimo

AU - Tjønneland, Anne

AU - Vermeulen, Roel

AU - Wolf, Kathrin

AU - Zitt, Emanuel

AU - Brunekreef, Bert

AU - Thurston, George

AU - Hoek, Gerard

AU - Raaschou-Nielsen, Ole

AU - Nagel, Gabriele

N1 - Publisher Copyright: © 2023 Elsevier B.V.

PY - 2024

Y1 - 2024

N2 - It is unclear whether cancers of the upper aerodigestive tract (UADT) and gastric cancer are related to air pollution, due to few studies with inconsistent results. The effects of particulate matter (PM) may vary across locations due to different source contributions and related PM compositions, and it is not clear which PM constituents/sources are most relevant from a consideration of overall mass concentration alone. We therefore investigated the association of UADT and gastric cancers with PM2.5 elemental constituents and sources components indicative of different sources within a large multicentre population based epidemiological study. Cohorts with at least 10 cases per cohort led to ten and eight cohorts from five countries contributing to UADT- and gastric cancer analysis, respectively. Outcome ascertainment was based on cancer registry data or data of comparable quality. We assigned home address exposure to eight elemental constituents (Cu, Fe, K, Ni, S, Si, V and Zn) estimated from Europe-wide exposure models, and five source components identified by absolute principal component analysis (APCA). Cox regression models were run with age as time scale, stratified for sex and cohort and adjusted for relevant individual and neighbourhood level confounders. We observed 1139 UADT and 872 gastric cancer cases during a mean follow-up of 18.3 and 18.5 years, respectively. UADT cancer incidence was associated with all constituents except K in single element analyses. After adjustment for NO2, only Ni and V remained associated with UADT. Residual oil combustion and traffic source components were associated with UADT cancer persisting in the multiple source model. No associations were found for any of the elements or source components and gastric cancer incidence. Our results indicate an association of several PM constituents indicative of different sources with UADT but not gastric cancer incidence with the most robust evidence for traffic and residual oil combustion.

AB - It is unclear whether cancers of the upper aerodigestive tract (UADT) and gastric cancer are related to air pollution, due to few studies with inconsistent results. The effects of particulate matter (PM) may vary across locations due to different source contributions and related PM compositions, and it is not clear which PM constituents/sources are most relevant from a consideration of overall mass concentration alone. We therefore investigated the association of UADT and gastric cancers with PM2.5 elemental constituents and sources components indicative of different sources within a large multicentre population based epidemiological study. Cohorts with at least 10 cases per cohort led to ten and eight cohorts from five countries contributing to UADT- and gastric cancer analysis, respectively. Outcome ascertainment was based on cancer registry data or data of comparable quality. We assigned home address exposure to eight elemental constituents (Cu, Fe, K, Ni, S, Si, V and Zn) estimated from Europe-wide exposure models, and five source components identified by absolute principal component analysis (APCA). Cox regression models were run with age as time scale, stratified for sex and cohort and adjusted for relevant individual and neighbourhood level confounders. We observed 1139 UADT and 872 gastric cancer cases during a mean follow-up of 18.3 and 18.5 years, respectively. UADT cancer incidence was associated with all constituents except K in single element analyses. After adjustment for NO2, only Ni and V remained associated with UADT. Residual oil combustion and traffic source components were associated with UADT cancer persisting in the multiple source model. No associations were found for any of the elements or source components and gastric cancer incidence. Our results indicate an association of several PM constituents indicative of different sources with UADT but not gastric cancer incidence with the most robust evidence for traffic and residual oil combustion.

KW - Air pollution

KW - Gastric cancer

KW - Long-term exposure

KW - Particulate matter (PM)

KW - PM composition

KW - PM sources

KW - Upper aerodigestive tract cancer

U2 - 10.1016/j.scitotenv.2023.168789

DO - 10.1016/j.scitotenv.2023.168789

M3 - Journal article

C2 - 37996018

AN - SCOPUS:85178634685

VL - 912

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

M1 - 168789

ER -

ID: 382332308