Measuring bothersome menopausal symptoms: development and validation of the MenoScores questionnaire
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Measuring bothersome menopausal symptoms : development and validation of the MenoScores questionnaire. / Lund, Kamma Sundgaard; Siersma, Volkert Dirk; Christensen, Karl Bang; Waldorff, Frans Boch; Brodersen, John.
In: Health and Quality of Life Outcomes, Vol. 16, 97, 2018.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Measuring bothersome menopausal symptoms
T2 - development and validation of the MenoScores questionnaire
AU - Lund, Kamma Sundgaard
AU - Siersma, Volkert Dirk
AU - Christensen, Karl Bang
AU - Waldorff, Frans Boch
AU - Brodersen, John
PY - 2018
Y1 - 2018
N2 - BACKGROUND: The experience of menopausal symptoms is common and an adequate patient-reported outcome measure is crucial in studies where women are treated for these symptoms. The aims of this study were to identify a patient-reported outcome measure for bothersome menopausal symptoms and, in the absence of an adequate tool, to develop a new measure with high content validity, and to validate it using modern psychometric methods. METHODS: The literature was reviewed for existing questionnaires and checklists for bothersome menopausal symptoms. Relevant items were extracted and subsequently tested in group interviews, single interviews, and pilot tests. A patient-reported outcome measure was drafted and completed by 1504 women. Data was collected and psychometrically validated using item-response theory Rasch Models. RESULTS: All questionnaires identified in the literature lacked content validity regarding bothersome menopausal symptoms and none were validated using item-response theory. Our content validation resulted in a draft measurement encompassing 122 items across eight domains. Following psychometrical validation, the final version of our patient-reported outcome measure, named the MenoScores Questionnaire, encompassed 51 items, including one single item, covering 11 scales. CONCLUSION: Menopausal symptoms are multidimensional with some symptoms unquestionably related to the menopausal transition. We identified four constructs of importance: hot flushes, day-and-night sweats, general sweating, and menopausal-specific sleeping problems. The MenoScores Questionnaire is condition-specific with high content validity and adequate psychometrical properties. It is designed to measure bothersome menopausal symptoms and all scales are developed and psychometrically validated using item-response theory Rasch Models. TRIAL REGISTRATION: Approved by the Danish Data Agency (J.nr. 2015-41-4057). Ethics Committee approval was not required.
AB - BACKGROUND: The experience of menopausal symptoms is common and an adequate patient-reported outcome measure is crucial in studies where women are treated for these symptoms. The aims of this study were to identify a patient-reported outcome measure for bothersome menopausal symptoms and, in the absence of an adequate tool, to develop a new measure with high content validity, and to validate it using modern psychometric methods. METHODS: The literature was reviewed for existing questionnaires and checklists for bothersome menopausal symptoms. Relevant items were extracted and subsequently tested in group interviews, single interviews, and pilot tests. A patient-reported outcome measure was drafted and completed by 1504 women. Data was collected and psychometrically validated using item-response theory Rasch Models. RESULTS: All questionnaires identified in the literature lacked content validity regarding bothersome menopausal symptoms and none were validated using item-response theory. Our content validation resulted in a draft measurement encompassing 122 items across eight domains. Following psychometrical validation, the final version of our patient-reported outcome measure, named the MenoScores Questionnaire, encompassed 51 items, including one single item, covering 11 scales. CONCLUSION: Menopausal symptoms are multidimensional with some symptoms unquestionably related to the menopausal transition. We identified four constructs of importance: hot flushes, day-and-night sweats, general sweating, and menopausal-specific sleeping problems. The MenoScores Questionnaire is condition-specific with high content validity and adequate psychometrical properties. It is designed to measure bothersome menopausal symptoms and all scales are developed and psychometrically validated using item-response theory Rasch Models. TRIAL REGISTRATION: Approved by the Danish Data Agency (J.nr. 2015-41-4057). Ethics Committee approval was not required.
U2 - 10.1186/s12955-018-0927-6
DO - 10.1186/s12955-018-0927-6
M3 - Journal article
C2 - 29769073
VL - 16
JO - Health and Quality of Life Outcomes
JF - Health and Quality of Life Outcomes
SN - 1477-7525
M1 - 97
ER -
ID: 196878795