Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis
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Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation : A European Meta-Analysis. / Birks, Laura; Casas, Maribel; Garcia, Ana M.; Alexander, Jan; Barros, Henrique; Bergstrom, Anna; Bonde, Jens Peter; Burdorf, Alex; Costet, Nathalie; Danileviciute, Asta; Eggesbo, Merete; Fernandez, Mariana F.; Gonzalez-Galarzo, M. Carmen; Grazuleviciene, Regina; Hanke, Wojciech; Jaddoe, Vincent; Kogevinas, Manolis; Kull, Inger; Lertxundi, Aitana; Melaki, Vasiliki; Andersen, Anne-Marie Nybo; Olea, Nicols; Polanska, Kinga; Rusconi, Franca; Santa Marina, Loreto; Santos, Ana Cristina; Vrijkotte, Tanja; Zugna, Daniela; Nieuwenhuijsen, Mark; Cordier, Sylvaine; Vrijheid, Martine.
In: Environmental Health Perspectives, Vol. 124, No. 11, 11.2016, p. 1785-1793.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation
T2 - A European Meta-Analysis
AU - Birks, Laura
AU - Casas, Maribel
AU - Garcia, Ana M.
AU - Alexander, Jan
AU - Barros, Henrique
AU - Bergstrom, Anna
AU - Bonde, Jens Peter
AU - Burdorf, Alex
AU - Costet, Nathalie
AU - Danileviciute, Asta
AU - Eggesbo, Merete
AU - Fernandez, Mariana F.
AU - Gonzalez-Galarzo, M. Carmen
AU - Grazuleviciene, Regina
AU - Hanke, Wojciech
AU - Jaddoe, Vincent
AU - Kogevinas, Manolis
AU - Kull, Inger
AU - Lertxundi, Aitana
AU - Melaki, Vasiliki
AU - Andersen, Anne-Marie Nybo
AU - Olea, Nicols
AU - Polanska, Kinga
AU - Rusconi, Franca
AU - Santa Marina, Loreto
AU - Santos, Ana Cristina
AU - Vrijkotte, Tanja
AU - Zugna, Daniela
AU - Nieuwenhuijsen, Mark
AU - Cordier, Sylvaine
AU - Vrijheid, Martine
PY - 2016/11
Y1 - 2016/11
N2 - Background: Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth.Objectives: We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery.Methods: Using individual participant data from 133,957 mother–child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates.Results: Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p < 0.05) with the other outcomes; women holding job titles classified as exposed to bisphenol A or brominated flame retardants were at higher risk for longer length of gestation.Conclusion: Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW.
AB - Background: Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth.Objectives: We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery.Methods: Using individual participant data from 133,957 mother–child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates.Results: Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p < 0.05) with the other outcomes; women holding job titles classified as exposed to bisphenol A or brominated flame retardants were at higher risk for longer length of gestation.Conclusion: Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW.
U2 - 10.1289/EHP208
DO - 10.1289/EHP208
M3 - Journal article
C2 - 27152464
VL - 124
SP - 1785
EP - 1793
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 11
ER -
ID: 169158593