Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania. / Alifrangis, Michael; Dalgaard, Michael B; Lusingu, John P; Vestergaard, Lasse S; Staalsoe, Trine; Jensen, Anja T R; Enevold, Anders; Rønn, Anita M; Khalil, Insaf F; Warhurst, David C; Lemnge, Martha M; Theander, Thor G; Bygbjerg, Ib C.

In: Journal of Infectious Diseases, Vol. 193, No. 12, 2006, p. 1738-41.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Alifrangis, M, Dalgaard, MB, Lusingu, JP, Vestergaard, LS, Staalsoe, T, Jensen, ATR, Enevold, A, Rønn, AM, Khalil, IF, Warhurst, DC, Lemnge, MM, Theander, TG & Bygbjerg, IC 2006, 'Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania', Journal of Infectious Diseases, vol. 193, no. 12, pp. 1738-41. https://doi.org/10.1086/504269

APA

Alifrangis, M., Dalgaard, M. B., Lusingu, J. P., Vestergaard, L. S., Staalsoe, T., Jensen, A. T. R., Enevold, A., Rønn, A. M., Khalil, I. F., Warhurst, D. C., Lemnge, M. M., Theander, T. G., & Bygbjerg, I. C. (2006). Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania. Journal of Infectious Diseases, 193(12), 1738-41. https://doi.org/10.1086/504269

Vancouver

Alifrangis M, Dalgaard MB, Lusingu JP, Vestergaard LS, Staalsoe T, Jensen ATR et al. Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania. Journal of Infectious Diseases. 2006;193(12):1738-41. https://doi.org/10.1086/504269

Author

Alifrangis, Michael ; Dalgaard, Michael B ; Lusingu, John P ; Vestergaard, Lasse S ; Staalsoe, Trine ; Jensen, Anja T R ; Enevold, Anders ; Rønn, Anita M ; Khalil, Insaf F ; Warhurst, David C ; Lemnge, Martha M ; Theander, Thor G ; Bygbjerg, Ib C. / Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania. In: Journal of Infectious Diseases. 2006 ; Vol. 193, No. 12. pp. 1738-41.

Bibtex

@article{8affe540a0d411dd86a6000ea68e967b,
title = "Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania",
abstract = "Two main haplotypes, CVIET and SVMNT, of the Plasmodium falciparum chloroquine-resistance transporter gene (Pfcrt) are linked to 4-aminoquinoline resistance. The CVIET haplotype has been reported in most malaria-endemic regions, whereas the SVMNT haplotype has only been found outside Africa. We investigated Pfcrt haplotype frequencies in Korogwe District, Tanzania, in 2003 and 2004. The SVMNT haplotype was not detected in 2003 but was found in 19% of infected individuals in 2004. Amodiaquine use has increased in the region. The introduction and high prevalence of the SVMNT haplotype may reflect this and may raise concern regarding the use of amodiaquine in artemisinin-based combination therapies in Africa.",
author = "Michael Alifrangis and Dalgaard, {Michael B} and Lusingu, {John P} and Vestergaard, {Lasse S} and Trine Staalsoe and Jensen, {Anja T R} and Anders Enevold and R{\o}nn, {Anita M} and Khalil, {Insaf F} and Warhurst, {David C} and Lemnge, {Martha M} and Theander, {Thor G} and Bygbjerg, {Ib C}",
note = "Keywords: Adolescent; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Gene Frequency; Haplotypes; Humans; Malaria, Falciparum; Membrane Proteins; Membrane Transport Proteins; Plasmodium falciparum; Protozoan Proteins; Tanzania",
year = "2006",
doi = "10.1086/504269",
language = "English",
volume = "193",
pages = "1738--41",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "12",

}

RIS

TY - JOUR

T1 - Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania

AU - Alifrangis, Michael

AU - Dalgaard, Michael B

AU - Lusingu, John P

AU - Vestergaard, Lasse S

AU - Staalsoe, Trine

AU - Jensen, Anja T R

AU - Enevold, Anders

AU - Rønn, Anita M

AU - Khalil, Insaf F

AU - Warhurst, David C

AU - Lemnge, Martha M

AU - Theander, Thor G

AU - Bygbjerg, Ib C

N1 - Keywords: Adolescent; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Gene Frequency; Haplotypes; Humans; Malaria, Falciparum; Membrane Proteins; Membrane Transport Proteins; Plasmodium falciparum; Protozoan Proteins; Tanzania

PY - 2006

Y1 - 2006

N2 - Two main haplotypes, CVIET and SVMNT, of the Plasmodium falciparum chloroquine-resistance transporter gene (Pfcrt) are linked to 4-aminoquinoline resistance. The CVIET haplotype has been reported in most malaria-endemic regions, whereas the SVMNT haplotype has only been found outside Africa. We investigated Pfcrt haplotype frequencies in Korogwe District, Tanzania, in 2003 and 2004. The SVMNT haplotype was not detected in 2003 but was found in 19% of infected individuals in 2004. Amodiaquine use has increased in the region. The introduction and high prevalence of the SVMNT haplotype may reflect this and may raise concern regarding the use of amodiaquine in artemisinin-based combination therapies in Africa.

AB - Two main haplotypes, CVIET and SVMNT, of the Plasmodium falciparum chloroquine-resistance transporter gene (Pfcrt) are linked to 4-aminoquinoline resistance. The CVIET haplotype has been reported in most malaria-endemic regions, whereas the SVMNT haplotype has only been found outside Africa. We investigated Pfcrt haplotype frequencies in Korogwe District, Tanzania, in 2003 and 2004. The SVMNT haplotype was not detected in 2003 but was found in 19% of infected individuals in 2004. Amodiaquine use has increased in the region. The introduction and high prevalence of the SVMNT haplotype may reflect this and may raise concern regarding the use of amodiaquine in artemisinin-based combination therapies in Africa.

U2 - 10.1086/504269

DO - 10.1086/504269

M3 - Journal article

C2 - 16703518

VL - 193

SP - 1738

EP - 1741

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 12

ER -

ID: 6765153