Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts
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Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts. / Raaschou-Nielsen, Ole; Pedersen, Marie; Stafoggia, Massimo; Weinmayr, Gudrun; Andersen, Zorana J.; Galassi, Claudia; Sommar, Johan; Forsberg, Bertil; Olsson, David; Oftedal, Bente; Krog, Norun H.; Aasvang, Gunn Marit; Pyko, Andrei; Pershagen, Göran; Korek, Michal; De Faire, Ulf; Pedersen, Nancy L.; Östenson, Claes-Göran; Fratiglioni, Laura; Sørensen, Mette; Eriksen, Kirsten T.; Tjønneland, Anne; Peeters, Petra H.; Bueno-de-Mesquita, H. B(as); Plusquin, Michelle; Key, Timothy J.; Jaensch, Andrea; Nagel, Gabriele; Föger, Bernhard; Wang, Meng; Tsai, Ming-Yi; Grioni, Sara; Marcon, Alessandro; Krogh, Vittorio; Ricceri, Fulvio; Sacerdote, Carlotta; Migliore, Enrica; Tamayo, Ibon; Amiano, Pilar; Dorronsoro, Miren; Sokhi, Ranjeet; Kooter, Ingeborg; de Hoogh, Kees; Beelen, Rob; Eeftens, Marloes; Vermeulen, Roel; Vineis, Paolo; Brunekreef, Bert; Hoek, Gerard.
In: International Journal of Cancer, Vol. 140, No. 7, 01.04.2017, p. 1528–1537.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts
AU - Raaschou-Nielsen, Ole
AU - Pedersen, Marie
AU - Stafoggia, Massimo
AU - Weinmayr, Gudrun
AU - Andersen, Zorana J.
AU - Galassi, Claudia
AU - Sommar, Johan
AU - Forsberg, Bertil
AU - Olsson, David
AU - Oftedal, Bente
AU - Krog, Norun H.
AU - Aasvang, Gunn Marit
AU - Pyko, Andrei
AU - Pershagen, Göran
AU - Korek, Michal
AU - De Faire, Ulf
AU - Pedersen, Nancy L.
AU - Östenson, Claes-Göran
AU - Fratiglioni, Laura
AU - Sørensen, Mette
AU - Eriksen, Kirsten T.
AU - Tjønneland, Anne
AU - Peeters, Petra H.
AU - Bueno-de-Mesquita, H. B(as)
AU - Plusquin, Michelle
AU - Key, Timothy J.
AU - Jaensch, Andrea
AU - Nagel, Gabriele
AU - Föger, Bernhard
AU - Wang, Meng
AU - Tsai, Ming-Yi
AU - Grioni, Sara
AU - Marcon, Alessandro
AU - Krogh, Vittorio
AU - Ricceri, Fulvio
AU - Sacerdote, Carlotta
AU - Migliore, Enrica
AU - Tamayo, Ibon
AU - Amiano, Pilar
AU - Dorronsoro, Miren
AU - Sokhi, Ranjeet
AU - Kooter, Ingeborg
AU - de Hoogh, Kees
AU - Beelen, Rob
AU - Eeftens, Marloes
AU - Vermeulen, Roel
AU - Vineis, Paolo
AU - Brunekreef, Bert
AU - Hoek, Gerard
N1 - © 2016 UICC.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Several studies have indicated weakly increased risk for kidney cancer among occupational groups exposed to gasoline vapors, engine exhaust, polycyclic aromatic hydrocarbons and other air pollutants, although not consistently. It was the aim to investigate possible associations between outdoor air pollution at the residence and the incidence of kidney parenchyma cancer in the general population. We used data from 14 European cohorts from the ESCAPE study. We geocoded and assessed air pollution concentrations at baseline addresses by land-use regression models for particulate matter (PM10 , PM2.5 , PMcoarse , PM2.5 absorbance (soot)) and nitrogen oxides (NO2 , NOx ), and collected data on traffic. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses to calculate summary hazard ratios (HRs). The 289,002 cohort members contributed 4,111,908 person-years at risk. During follow-up (mean 14.2 years) 697 incident cancers of the kidney parenchyma were diagnosed. The meta-analyses showed higher HRs in association with higher PM concentration, e.g. HR = 1.57 (95%CI: 0.81-3.01) per 5 μg/m(3) PM2.5 and HR = 1.36 (95%CI: 0.84-2.19) per 10(-5) m(-1) PM2.5 absorbance, albeit never statistically significant. The HRs in association with nitrogen oxides and traffic density on the nearest street were slightly above one. Sensitivity analyses among participants who did not change residence during follow-up showed stronger associations, but none were statistically significant. Our study provides suggestive evidence that exposure to outdoor PM at the residence may be associated with higher risk for kidney parenchyma cancer; the results should be interpreted cautiously as associations may be due to chance.
AB - Several studies have indicated weakly increased risk for kidney cancer among occupational groups exposed to gasoline vapors, engine exhaust, polycyclic aromatic hydrocarbons and other air pollutants, although not consistently. It was the aim to investigate possible associations between outdoor air pollution at the residence and the incidence of kidney parenchyma cancer in the general population. We used data from 14 European cohorts from the ESCAPE study. We geocoded and assessed air pollution concentrations at baseline addresses by land-use regression models for particulate matter (PM10 , PM2.5 , PMcoarse , PM2.5 absorbance (soot)) and nitrogen oxides (NO2 , NOx ), and collected data on traffic. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses to calculate summary hazard ratios (HRs). The 289,002 cohort members contributed 4,111,908 person-years at risk. During follow-up (mean 14.2 years) 697 incident cancers of the kidney parenchyma were diagnosed. The meta-analyses showed higher HRs in association with higher PM concentration, e.g. HR = 1.57 (95%CI: 0.81-3.01) per 5 μg/m(3) PM2.5 and HR = 1.36 (95%CI: 0.84-2.19) per 10(-5) m(-1) PM2.5 absorbance, albeit never statistically significant. The HRs in association with nitrogen oxides and traffic density on the nearest street were slightly above one. Sensitivity analyses among participants who did not change residence during follow-up showed stronger associations, but none were statistically significant. Our study provides suggestive evidence that exposure to outdoor PM at the residence may be associated with higher risk for kidney parenchyma cancer; the results should be interpreted cautiously as associations may be due to chance.
U2 - 10.1002/ijc.30587
DO - 10.1002/ijc.30587
M3 - Journal article
C2 - 28006861
VL - 140
SP - 1528
EP - 1537
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 7
ER -
ID: 171582815