Parental age at birth and biomarkers of fecundity in young Danish men
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Parental age at birth and biomarkers of fecundity in young Danish men. / Ernst, Andreas; Brix, Nis; Gaml-Sørensen, Anne; Arendt, Linn Håkonsen; Toft, Gunnar; Tøttenborg, Sandra Søgaard; Hougaard, Karin Søring; Bonde, Jens Peter Ellekilde; Ramlau-Hansen, Cecilia Høst.
In: Andrology, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Parental age at birth and biomarkers of fecundity in young Danish men
AU - Ernst, Andreas
AU - Brix, Nis
AU - Gaml-Sørensen, Anne
AU - Arendt, Linn Håkonsen
AU - Toft, Gunnar
AU - Tøttenborg, Sandra Søgaard
AU - Hougaard, Karin Søring
AU - Bonde, Jens Peter Ellekilde
AU - Ramlau-Hansen, Cecilia Høst
N1 - Publisher Copyright: © 2023 The Authors. Andrology published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology.
PY - 2023
Y1 - 2023
N2 - Background: High parental age is associated with adverse birth and genetic outcomes, but little is known about fecundity in male offspring. Objectives: We investigated if high parental age at birth was associated with biomarkers of male fecundity in a large population-based sample of young men. Materials and methods: We conducted a study of 1057 men from the Fetal Programming of Semen Quality (FEPOS) cohort, a sub-cohort of sons born 1998–2000 into the Danish National Birth Cohort. Semen characteristics and reproductive hormone concentrations were measured in samples provided by the men 2017–2019. Testis volume was determined by self-measurement. Data on the parental age was drawn from registers. Adjusted relative difference in percentage with 95% confidence intervals were estimated for each outcome according to pre-specified maternal and paternal age groups (< 30 (reference), 30–34 and ≥ 35) as well as for combinations of parental age groups, using multivariable negative binomial regression models. Results: We did not observe consistent associations between parental age and biomarkers of fecundity, although sons of mothers ≥ 35 years had lower sperm concentration (−15% (95% CI: −30, 3)) and total sperm count (−10% (95% CI: −25, 9)). The analysis with parental age combinations showed lower sperm concentration with high age of the parents (both ≥ 35 years: −27%, 95% CI: −40, −19) when compared to the reference where both parents were below 30 years. Discussion and conclusion: We found no strong association between higher parental age and biomarkers of fecundity in young men. However, we cannot exclude poorer semen characteristics in sons born by older mothers or with high age of both parents.
AB - Background: High parental age is associated with adverse birth and genetic outcomes, but little is known about fecundity in male offspring. Objectives: We investigated if high parental age at birth was associated with biomarkers of male fecundity in a large population-based sample of young men. Materials and methods: We conducted a study of 1057 men from the Fetal Programming of Semen Quality (FEPOS) cohort, a sub-cohort of sons born 1998–2000 into the Danish National Birth Cohort. Semen characteristics and reproductive hormone concentrations were measured in samples provided by the men 2017–2019. Testis volume was determined by self-measurement. Data on the parental age was drawn from registers. Adjusted relative difference in percentage with 95% confidence intervals were estimated for each outcome according to pre-specified maternal and paternal age groups (< 30 (reference), 30–34 and ≥ 35) as well as for combinations of parental age groups, using multivariable negative binomial regression models. Results: We did not observe consistent associations between parental age and biomarkers of fecundity, although sons of mothers ≥ 35 years had lower sperm concentration (−15% (95% CI: −30, 3)) and total sperm count (−10% (95% CI: −25, 9)). The analysis with parental age combinations showed lower sperm concentration with high age of the parents (both ≥ 35 years: −27%, 95% CI: −40, −19) when compared to the reference where both parents were below 30 years. Discussion and conclusion: We found no strong association between higher parental age and biomarkers of fecundity in young men. However, we cannot exclude poorer semen characteristics in sons born by older mothers or with high age of both parents.
KW - cohort study
KW - epidemiology
KW - parental age
KW - paternal factors
KW - reproductive health
KW - semen quality
U2 - 10.1111/andr.13536
DO - 10.1111/andr.13536
M3 - Journal article
C2 - 37750236
AN - SCOPUS:85172108985
JO - Journal of Andrology
JF - Journal of Andrology
SN - 2047-2919
ER -
ID: 369910587