TY - JOUR

T1 - Perspective

T2 - Metabotyping - A potential personalized nutrition strategy for precision prevention of cardiometabolic disease

AU - Palmnäs, Marie

AU - Brunius, Carl

AU - Shi, Lin

AU - Rostgaard-Hansen, Agneta Linn

AU - Torres, Núria Estanyol

AU - González-Domínguez, Raúl

AU - Zamora-Ros, Raul

AU - Ye, Ye Lingqun

AU - Halkjær, Jytte

AU - Tjønneland, Anne

AU - Riccardi, Gabriele

AU - Giacco, Rosalba

AU - Costabile, Giuseppina

AU - Vetrani, Claudia

AU - Nielsen, Jens

AU - Andres-Lacueva, Cristina

AU - Landberg, Rikard

N1 - (Ekstern)

PY - 2020

Y1 - 2020

N2 - Diet is an important, modifiable lifestyle factor of cardiometabolic disease risk, and an improved diet can delay or even prevent the onset of disease. Recent evidence suggests that individuals could benefit from diets adapted to their genotype and phenotype: that is, personalized nutrition. A novel strategy is to tailor diets for groups of individuals according to their metabolic phenotypes (metabotypes). Randomized controlled trials evaluating metabotype-specific responses and nonresponses are urgently needed to bridge the current gap of knowledge with regard to the efficacy of personalized strategies in nutrition. In this Perspective, we discuss the concept of metabotyping, review the current literature on metabotyping in the context of cardiometabolic disease prevention, and suggest potential strategies for metabotype-based nutritional advice for future work. We also discuss potential determinants of metabotypes, including gut microbiota, and highlight the use of metabolomics to define effective markers for cardiometabolic disease-related metabotypes. Moreover, we hypothesize that people at high risk for cardiometabolic diseases have distinct metabotypes and that individuals grouped into specific metabotypes may respond differently to the same diet, which is being tested in a project of the Joint Programming Initiative: A Healthy Diet for a Healthy Life.

AB - Diet is an important, modifiable lifestyle factor of cardiometabolic disease risk, and an improved diet can delay or even prevent the onset of disease. Recent evidence suggests that individuals could benefit from diets adapted to their genotype and phenotype: that is, personalized nutrition. A novel strategy is to tailor diets for groups of individuals according to their metabolic phenotypes (metabotypes). Randomized controlled trials evaluating metabotype-specific responses and nonresponses are urgently needed to bridge the current gap of knowledge with regard to the efficacy of personalized strategies in nutrition. In this Perspective, we discuss the concept of metabotyping, review the current literature on metabotyping in the context of cardiometabolic disease prevention, and suggest potential strategies for metabotype-based nutritional advice for future work. We also discuss potential determinants of metabotypes, including gut microbiota, and highlight the use of metabolomics to define effective markers for cardiometabolic disease-related metabotypes. Moreover, we hypothesize that people at high risk for cardiometabolic diseases have distinct metabotypes and that individuals grouped into specific metabotypes may respond differently to the same diet, which is being tested in a project of the Joint Programming Initiative: A Healthy Diet for a Healthy Life.

KW - Cardiometabolic diseases

KW - Gut microbiota

KW - Metabolomics

KW - Metabotyping

KW - Personalized nutrition

KW - Precision nutrition

KW - Targeted nutrition

UR - http://www.scopus.com/inward/record.url?scp=85084784206&partnerID=8YFLogxK

U2 - 10.1093/advances/nmz121

DO - 10.1093/advances/nmz121

M3 - Journal article

C2 - 31782487

AN - SCOPUS:85084784206

VL - 11

SP - 524

EP - 532

JO - Advances in Nutrition

JF - Advances in Nutrition

SN - 2161-8313

IS - 3

ER -