Physical activity as intervention for age-related loss of muscle mass and function: protocol for a randomised controlled trial (the LISA study)

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Physical activity as intervention for age-related loss of muscle mass and function : protocol for a randomised controlled trial (the LISA study). / Eriksen, Christian Skou; Garde, Ellen; Reislev, Nina Linde; Wimmelmann, Cathrine Lawaetz; Bieler, Theresa; Ziegler, Andreas Kraag; Gylling, Anne Theil; Dideriksen, Kasper Juel; Siebner, Hartwig Roman; Mortensen, Erik Lykke; Kjaer, Michael.

In: B M J Open, Vol. 6, No. 12, e012951, 12.2016, p. 1-13.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Eriksen, CS, Garde, E, Reislev, NL, Wimmelmann, CL, Bieler, T, Ziegler, AK, Gylling, AT, Dideriksen, KJ, Siebner, HR, Mortensen, EL & Kjaer, M 2016, 'Physical activity as intervention for age-related loss of muscle mass and function: protocol for a randomised controlled trial (the LISA study)', B M J Open, vol. 6, no. 12, e012951, pp. 1-13. https://doi.org/10.1136/bmjopen-2016-012951

APA

Eriksen, C. S., Garde, E., Reislev, N. L., Wimmelmann, C. L., Bieler, T., Ziegler, A. K., ... Kjaer, M. (2016). Physical activity as intervention for age-related loss of muscle mass and function: protocol for a randomised controlled trial (the LISA study). B M J Open, 6(12), 1-13. [e012951]. https://doi.org/10.1136/bmjopen-2016-012951

Vancouver

Eriksen CS, Garde E, Reislev NL, Wimmelmann CL, Bieler T, Ziegler AK et al. Physical activity as intervention for age-related loss of muscle mass and function: protocol for a randomised controlled trial (the LISA study). B M J Open. 2016 Dec;6(12):1-13. e012951. https://doi.org/10.1136/bmjopen-2016-012951

Author

Eriksen, Christian Skou ; Garde, Ellen ; Reislev, Nina Linde ; Wimmelmann, Cathrine Lawaetz ; Bieler, Theresa ; Ziegler, Andreas Kraag ; Gylling, Anne Theil ; Dideriksen, Kasper Juel ; Siebner, Hartwig Roman ; Mortensen, Erik Lykke ; Kjaer, Michael. / Physical activity as intervention for age-related loss of muscle mass and function : protocol for a randomised controlled trial (the LISA study). In: B M J Open. 2016 ; Vol. 6, No. 12. pp. 1-13.

Bibtex

@article{31abb284782744598a0f86a0e276d8da,
title = "Physical activity as intervention for age-related loss of muscle mass and function: protocol for a randomised controlled trial (the LISA study)",
abstract = "INTRODUCTION: Physical and cognitive function decline with age, accelerating during the 6th decade. Loss of muscle power (force×velocity product) is a dominant physical determinant for loss of functional ability, especially if the lower extremities are affected. Muscle strength training is known to maintain or even improve muscle power as well as physical function in older adults, but the optimal type of training for beneficial long-term training effects over several years is unknown. Moreover, the impact of muscle strength training on cognitive function and brain structure remains speculative. The primary aim of this randomised controlled trial is to compare the efficacy of two different 1 year strength training regimens on immediate and long-lasting improvements in muscle power in retirement-age individuals. Secondary aims are to evaluate the effect on muscle strength, muscle mass, physical and cognitive function, mental well-being, health-related quality of life and brain morphology.METHODS AND ANALYSIS: The study includes 450 home-dwelling men and women (62-70 years). Participants are randomly allocated to (1) 1 year of supervised, centre-based heavy resistance training, (2) home-based moderate intensity resistance training or (3) habitual physical activity (control). Changes in primary (leg extensor power) and secondary outcomes are analysed according to the intention to treat principle and per protocol at 1, 2, 4, 7 and 10 years.ETHICS AND DISSEMINATION: The study is expected to generate new insights into training-induced promotion of functional ability and independency after retirement and will help to formulate national recommendations regarding physical activity schemes for the growing population of older individuals in western societies. Results will be published in scientific peer-reviewed journals, in PhD theses and at public meetings. The study is approved by the Regional Ethical Committee (Capital Region, Copenhagen, Denmark, number H-3-2014-017).TRIAL REGISTRATION NUMBER: NCT02123641.",
author = "Eriksen, {Christian Skou} and Ellen Garde and Reislev, {Nina Linde} and Wimmelmann, {Cathrine Lawaetz} and Theresa Bieler and Ziegler, {Andreas Kraag} and Gylling, {Anne Theil} and Dideriksen, {Kasper Juel} and Siebner, {Hartwig Roman} and Mortensen, {Erik Lykke} and Michael Kjaer",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.",
year = "2016",
month = "12",
doi = "10.1136/bmjopen-2016-012951",
language = "English",
volume = "6",
pages = "1--13",
journal = "B M J Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "12",

}

RIS

TY - JOUR

T1 - Physical activity as intervention for age-related loss of muscle mass and function

T2 - protocol for a randomised controlled trial (the LISA study)

AU - Eriksen, Christian Skou

AU - Garde, Ellen

AU - Reislev, Nina Linde

AU - Wimmelmann, Cathrine Lawaetz

AU - Bieler, Theresa

AU - Ziegler, Andreas Kraag

AU - Gylling, Anne Theil

AU - Dideriksen, Kasper Juel

AU - Siebner, Hartwig Roman

AU - Mortensen, Erik Lykke

AU - Kjaer, Michael

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

PY - 2016/12

Y1 - 2016/12

N2 - INTRODUCTION: Physical and cognitive function decline with age, accelerating during the 6th decade. Loss of muscle power (force×velocity product) is a dominant physical determinant for loss of functional ability, especially if the lower extremities are affected. Muscle strength training is known to maintain or even improve muscle power as well as physical function in older adults, but the optimal type of training for beneficial long-term training effects over several years is unknown. Moreover, the impact of muscle strength training on cognitive function and brain structure remains speculative. The primary aim of this randomised controlled trial is to compare the efficacy of two different 1 year strength training regimens on immediate and long-lasting improvements in muscle power in retirement-age individuals. Secondary aims are to evaluate the effect on muscle strength, muscle mass, physical and cognitive function, mental well-being, health-related quality of life and brain morphology.METHODS AND ANALYSIS: The study includes 450 home-dwelling men and women (62-70 years). Participants are randomly allocated to (1) 1 year of supervised, centre-based heavy resistance training, (2) home-based moderate intensity resistance training or (3) habitual physical activity (control). Changes in primary (leg extensor power) and secondary outcomes are analysed according to the intention to treat principle and per protocol at 1, 2, 4, 7 and 10 years.ETHICS AND DISSEMINATION: The study is expected to generate new insights into training-induced promotion of functional ability and independency after retirement and will help to formulate national recommendations regarding physical activity schemes for the growing population of older individuals in western societies. Results will be published in scientific peer-reviewed journals, in PhD theses and at public meetings. The study is approved by the Regional Ethical Committee (Capital Region, Copenhagen, Denmark, number H-3-2014-017).TRIAL REGISTRATION NUMBER: NCT02123641.

AB - INTRODUCTION: Physical and cognitive function decline with age, accelerating during the 6th decade. Loss of muscle power (force×velocity product) is a dominant physical determinant for loss of functional ability, especially if the lower extremities are affected. Muscle strength training is known to maintain or even improve muscle power as well as physical function in older adults, but the optimal type of training for beneficial long-term training effects over several years is unknown. Moreover, the impact of muscle strength training on cognitive function and brain structure remains speculative. The primary aim of this randomised controlled trial is to compare the efficacy of two different 1 year strength training regimens on immediate and long-lasting improvements in muscle power in retirement-age individuals. Secondary aims are to evaluate the effect on muscle strength, muscle mass, physical and cognitive function, mental well-being, health-related quality of life and brain morphology.METHODS AND ANALYSIS: The study includes 450 home-dwelling men and women (62-70 years). Participants are randomly allocated to (1) 1 year of supervised, centre-based heavy resistance training, (2) home-based moderate intensity resistance training or (3) habitual physical activity (control). Changes in primary (leg extensor power) and secondary outcomes are analysed according to the intention to treat principle and per protocol at 1, 2, 4, 7 and 10 years.ETHICS AND DISSEMINATION: The study is expected to generate new insights into training-induced promotion of functional ability and independency after retirement and will help to formulate national recommendations regarding physical activity schemes for the growing population of older individuals in western societies. Results will be published in scientific peer-reviewed journals, in PhD theses and at public meetings. The study is approved by the Regional Ethical Committee (Capital Region, Copenhagen, Denmark, number H-3-2014-017).TRIAL REGISTRATION NUMBER: NCT02123641.

U2 - 10.1136/bmjopen-2016-012951

DO - 10.1136/bmjopen-2016-012951

M3 - Journal article

VL - 6

SP - 1

EP - 13

JO - B M J Open

JF - B M J Open

SN - 2044-6055

IS - 12

M1 - e012951

ER -

ID: 171587165