Polyphenol intake and epithelial ovarian cancer risk in the european prospective investigation into cancer and nutrition (Epic) study
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Polyphenol intake and epithelial ovarian cancer risk in the european prospective investigation into cancer and nutrition (Epic) study. / Londoño, Catalina; Cayssials, Valerie; de Villasante, Izar; Crous-Bou, Marta; Scalbert, Augustin; Weiderpass, Elisabete; Agudo, Antonio; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Katzke, Verena; Schulze, Matthias; Palli, Domenico; Krogh, Vittorio; de Magistris, Maria Santucci; Tumino, Rosario; Ricceri, Fulvio; Gram, Inger T.; Rylander, Charlotta; Skeie, Guri; Sánchez, Maria Jose; Amiano, Pilar; Huerta, José María; Barricarte, Aurelio; Sartor, Hanna; Sonestedt, Emily; Esberg, Anders; Idahl, Annika; Mahamat-Saleh, Yahya; Laouali, Nasser; Kvaskoff, Marina; Turzanski-Fortner, Renée; Zamora-Ros, Raul.
In: Antioxidants, Vol. 10, No. 8, 1249, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Polyphenol intake and epithelial ovarian cancer risk in the european prospective investigation into cancer and nutrition (Epic) study
AU - Londoño, Catalina
AU - Cayssials, Valerie
AU - de Villasante, Izar
AU - Crous-Bou, Marta
AU - Scalbert, Augustin
AU - Weiderpass, Elisabete
AU - Agudo, Antonio
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Overvad, Kim
AU - Katzke, Verena
AU - Schulze, Matthias
AU - Palli, Domenico
AU - Krogh, Vittorio
AU - de Magistris, Maria Santucci
AU - Tumino, Rosario
AU - Ricceri, Fulvio
AU - Gram, Inger T.
AU - Rylander, Charlotta
AU - Skeie, Guri
AU - Sánchez, Maria Jose
AU - Amiano, Pilar
AU - Huerta, José María
AU - Barricarte, Aurelio
AU - Sartor, Hanna
AU - Sonestedt, Emily
AU - Esberg, Anders
AU - Idahl, Annika
AU - Mahamat-Saleh, Yahya
AU - Laouali, Nasser
AU - Kvaskoff, Marina
AU - Turzanski-Fortner, Renée
AU - Zamora-Ros, Raul
N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospective study. The study was conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from the general population. Polyphenol intake was assessed through validated country-specific dietary questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours) were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest quartile of total polyphenol intake compared with the lowest quartile (HRQ4vsQ1 ) was 1.14 (95% CI 0.94–1.39; p-trend = 0.11). Similarly, the intake of most classes and subclasses of polyphenols were not related to either overall EOC risk or any EOC subtype. A borderline statistically significant positive association was observed between phenolic acid intake (HRQ4vsQ1 = 1.20, 95% CI 1.01–1.43; p-trend = 0.02) and EOC risk, especially for the serous subtype and in women with obesity, although these associations did not exceed the Bonferroni correction threshold. The current results do not support any association between polyphenol intake and EOC in our large European prospective study. Results regarding phenolic acid intake need further investigation.
AB - Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospective study. The study was conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from the general population. Polyphenol intake was assessed through validated country-specific dietary questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours) were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest quartile of total polyphenol intake compared with the lowest quartile (HRQ4vsQ1 ) was 1.14 (95% CI 0.94–1.39; p-trend = 0.11). Similarly, the intake of most classes and subclasses of polyphenols were not related to either overall EOC risk or any EOC subtype. A borderline statistically significant positive association was observed between phenolic acid intake (HRQ4vsQ1 = 1.20, 95% CI 1.01–1.43; p-trend = 0.02) and EOC risk, especially for the serous subtype and in women with obesity, although these associations did not exceed the Bonferroni correction threshold. The current results do not support any association between polyphenol intake and EOC in our large European prospective study. Results regarding phenolic acid intake need further investigation.
KW - Cohort
KW - EPIC
KW - Flavonoids
KW - Intake
KW - Ovarian cancer
KW - Polyphenols
U2 - 10.3390/antiox10081249
DO - 10.3390/antiox10081249
M3 - Journal article
C2 - 34439497
AN - SCOPUS:85111783395
VL - 10
JO - Antioxidants
JF - Antioxidants
SN - 2076-3921
IS - 8
M1 - 1249
ER -
ID: 286489232