Pregnancy associated plasma protein-A as a marker for myocardial infarction and death in patients with stable coronary artery disease: A prognostic study within the CLARICOR Trial
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Pregnancy associated plasma protein-A as a marker for myocardial infarction and death in patients with stable coronary artery disease: A prognostic study within the CLARICOR Trial. / Iversen, Kasper K; Teisner, Børge; Winkel, Per; Gluud, Christian; Kjøller, Erik; Kolmos, Hans Jørn; Hildebrandt, Per Rossen; Hilden, Jørgen; Kastrup, Jens; The CLARICOR Trial Group.
In: Atherosclerosis, Vol. 214, No. 1, 01.01.2011, p. 203-208.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pregnancy associated plasma protein-A as a marker for myocardial infarction and death in patients with stable coronary artery disease: A prognostic study within the CLARICOR Trial
AU - Iversen, Kasper K
AU - Teisner, Børge
AU - Winkel, Per
AU - Gluud, Christian
AU - Kjøller, Erik
AU - Kolmos, Hans Jørn
AU - Hildebrandt, Per Rossen
AU - Hilden, Jørgen
AU - Kastrup, Jens
AU - The CLARICOR Trial Group
N1 - Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - OBJECTIVE: Pregnancy associated plasma protein-A (PAPP-A) is a potential new marker for vulnerable plaques in the coronary arteries only examined in stable coronary disease (CAD) in patients undergoing coronary angiography. Here we address the prognostic value of serum PAPP-A in unselected stable CAD patients. METHOD: Blood samples were drawn at study entry. Serum PAPP-A values =4mIU/L were considered elevated. Mortality and non-fatal myocardial infarction was prospectively registered. The primary outcome was the composite outcome of myocardial infarction and all-cause mortality, secondary outcomes were all-cause mortality and myocardial infarction. RESULTS: Patients (n=4243) were followed for a median of 2.8 years. In a Cox analysis, elevated PAPP-A was significantly related to the composite outcome of myocardial infarction and death (HR 1.99, 95% CI 1.62-2.45, p
AB - OBJECTIVE: Pregnancy associated plasma protein-A (PAPP-A) is a potential new marker for vulnerable plaques in the coronary arteries only examined in stable coronary disease (CAD) in patients undergoing coronary angiography. Here we address the prognostic value of serum PAPP-A in unselected stable CAD patients. METHOD: Blood samples were drawn at study entry. Serum PAPP-A values =4mIU/L were considered elevated. Mortality and non-fatal myocardial infarction was prospectively registered. The primary outcome was the composite outcome of myocardial infarction and all-cause mortality, secondary outcomes were all-cause mortality and myocardial infarction. RESULTS: Patients (n=4243) were followed for a median of 2.8 years. In a Cox analysis, elevated PAPP-A was significantly related to the composite outcome of myocardial infarction and death (HR 1.99, 95% CI 1.62-2.45, p
U2 - 10.1016/j.atherosclerosis.2010.10.025
DO - 10.1016/j.atherosclerosis.2010.10.025
M3 - Journal article
C2 - 21093861
VL - 214
SP - 203
EP - 208
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 1
ER -
ID: 32108404