Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children
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Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children. / Smit, L A M; Lenters, V; Høyer, B B; Lindh, C H; Pedersen, H S; Liermontova, I; Jönsson, B A G; Piersma, A H; Bonde, J P; Toft, G; Vermeulen, R; Heederik, D.
In: Allergy, Vol. 70, No. 6, 2015, p. 653-660.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children
AU - Smit, L A M
AU - Lenters, V
AU - Høyer, B B
AU - Lindh, C H
AU - Pedersen, H S
AU - Liermontova, I
AU - Jönsson, B A G
AU - Piersma, A H
AU - Bonde, J P
AU - Toft, G
AU - Vermeulen, R
AU - Heederik, D
N1 - © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2015
Y1 - 2015
N2 - BACKGROUND: Emerging evidence suggests that prenatal or early-life exposures to environmental contaminants may contribute to an increased risk of asthma and allergies in children. We aimed to the explore associations of prenatal exposures to a large set of environmental chemical contaminants with asthma and eczema in school-age children.METHODS: We studied 1024 mother-child pairs from Greenland and Ukraine from the INUENDO birth cohort. Data were collected by means of an interview-based questionnaire when the children were 5-9 years of age. Questions from the ISAAC study were used to define asthma, eczema, and wheeze. We applied principal components analysis (PCA) to sixteen contaminants in maternal serum sampled during pregnancy, including perfluoroalkyl substances (PFASs), metabolites of diethylhexyl (DEHP) and diisononyl (DiNP) phthalates, PCB-153, and p,p'-DDE. Scores of five principal components (PCs) explaining 70% of the variance were included in multiple logistic regression models.RESULTS: In a meta-analysis that included both populations, the PC2 score, reflecting exposure to DiNP, was negatively associated with current eczema (OR 0.71, 95% CI 0.52-0.96). Other associations were not consistent between the two populations. In Ukrainian children, the PC3 score (DEHP) was positively associated with current wheeze (adjusted OR 1.56, 95% CI 1.03-2.37), whereas the PC5 score, dominated by perfluorooctanoic acid (PFOA), was inversely associated with current wheeze (OR 0.64, 0.41-0.99). In Greenlandic children, a negative association of PC4 (organochlorines) with ever eczema (OR 0.78, 0.61-0.99) was found.CONCLUSIONS: We found limited evidence to support a link between prenatal exposure to environmental chemical contaminants and childhood asthma and eczema.
AB - BACKGROUND: Emerging evidence suggests that prenatal or early-life exposures to environmental contaminants may contribute to an increased risk of asthma and allergies in children. We aimed to the explore associations of prenatal exposures to a large set of environmental chemical contaminants with asthma and eczema in school-age children.METHODS: We studied 1024 mother-child pairs from Greenland and Ukraine from the INUENDO birth cohort. Data were collected by means of an interview-based questionnaire when the children were 5-9 years of age. Questions from the ISAAC study were used to define asthma, eczema, and wheeze. We applied principal components analysis (PCA) to sixteen contaminants in maternal serum sampled during pregnancy, including perfluoroalkyl substances (PFASs), metabolites of diethylhexyl (DEHP) and diisononyl (DiNP) phthalates, PCB-153, and p,p'-DDE. Scores of five principal components (PCs) explaining 70% of the variance were included in multiple logistic regression models.RESULTS: In a meta-analysis that included both populations, the PC2 score, reflecting exposure to DiNP, was negatively associated with current eczema (OR 0.71, 95% CI 0.52-0.96). Other associations were not consistent between the two populations. In Ukrainian children, the PC3 score (DEHP) was positively associated with current wheeze (adjusted OR 1.56, 95% CI 1.03-2.37), whereas the PC5 score, dominated by perfluorooctanoic acid (PFOA), was inversely associated with current wheeze (OR 0.64, 0.41-0.99). In Greenlandic children, a negative association of PC4 (organochlorines) with ever eczema (OR 0.78, 0.61-0.99) was found.CONCLUSIONS: We found limited evidence to support a link between prenatal exposure to environmental chemical contaminants and childhood asthma and eczema.
KW - Asthma
KW - Child
KW - Child, Preschool
KW - Cohort Studies
KW - Dichlorodiphenyl Dichloroethylene
KW - Diethylhexyl Phthalate
KW - Eczema
KW - Environmental Exposure
KW - Environmental Pollutants
KW - Female
KW - Greenland
KW - Humans
KW - Hydrocarbons, Chlorinated
KW - Male
KW - Phthalic Acids
KW - Polychlorinated Biphenyls
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects
KW - Principal Component Analysis
KW - Respiratory Sounds
KW - Ukraine
U2 - 10.1111/all.12605
DO - 10.1111/all.12605
M3 - Journal article
C2 - 25753462
VL - 70
SP - 653
EP - 660
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 6
ER -
ID: 161731188