Progress of emphysema in severe α1-antitrypsin deficiency as assessed by annual CT
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Purpose: To assess serial CT as a measure of the progress of emphysema in patients with severe α1-antitrypsin deficiency (phenotype PiZ). Material and Methods: In a randomized placebo-controlled study of α1-antitrypsin augmentation therapy, 22 patients with moderate emphysema were followed for 2-4 years with an annual lung CT. The images were analysed by means of semiautomatic lung detection, and the degree of emphysema was quantitated by the density-mask and the percentile methods. The influence of lung volume was standardised by a regression model. Results: A highly significant decline in Hounsfield units (HU) was found in low-density areas corresponding to a mean (SE) annual loss of lung tissue of 2.1 (0.4) g/l lung volume. Analysis of a single slice at 5 cm below the level of the carina gave comparable results: 2.4 (0.4) g/1. Conclusion: Serial CT is a sensitive measure of the progress of emphysema in patients with severe α1-antitrypsin deficiency.
Original language | English |
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Journal | Acta Radiologica |
Volume | 38 |
Issue number | 5 |
Pages (from-to) | 826-832 |
Number of pages | 7 |
ISSN | 0284-1851 |
DOIs | |
Publication status | Published - 1997 |
- CT, Density, Lung, ventilation
Research areas
ID: 259164935