Prostate specific antigen in boys with precocious puberty before and during gonadal suppression by GnRH agonist treatment
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Prostate specific antigen in boys with precocious puberty before and during gonadal suppression by GnRH agonist treatment. / Juul, A; Müller, J; Skakkebaek, N E.
In: European Journal of Endocrinology, Vol. 136, No. 4, 1997, p. 401-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Prostate specific antigen in boys with precocious puberty before and during gonadal suppression by GnRH agonist treatment
AU - Juul, A
AU - Müller, J
AU - Skakkebaek, N E
PY - 1997
Y1 - 1997
N2 - In healthy boys, the pituitary-gonadal axis exhibits diurnal variation in early puberty. Serum testosterone levels are higher during the night and low or immeasurable during the day. These fluctuating levels of circulating androgens in early pubertal boys are difficult to monitor. Prostate specific antigen (PSA) is a marker of the androgen-dependent prostatic epithelial cell activity and it is used in the diagnosis and surveillance of adult patients with prostatic cancer. We have measured PSA concentrations in serum from boys with precocious puberty before and during gonadal suppression with GnRH agonists to evaluate the effect of normal and precocious puberty on PSA levels and to study the correlation between testosterone and PSA in boys.
AB - In healthy boys, the pituitary-gonadal axis exhibits diurnal variation in early puberty. Serum testosterone levels are higher during the night and low or immeasurable during the day. These fluctuating levels of circulating androgens in early pubertal boys are difficult to monitor. Prostate specific antigen (PSA) is a marker of the androgen-dependent prostatic epithelial cell activity and it is used in the diagnosis and surveillance of adult patients with prostatic cancer. We have measured PSA concentrations in serum from boys with precocious puberty before and during gonadal suppression with GnRH agonists to evaluate the effect of normal and precocious puberty on PSA levels and to study the correlation between testosterone and PSA in boys.
M3 - Journal article
VL - 136
SP - 401
EP - 405
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 4
ER -
ID: 48486494