Protein and amino acid intakes in relation to prostate cancer risk and mortality-A prospective study in the European Prospective Investigation into Cancer and Nutrition
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Protein and amino acid intakes in relation to prostate cancer risk and mortality-A prospective study in the European Prospective Investigation into Cancer and Nutrition. / Schmidt, Julie A.; Huybrechts, Inge; Overvad, Kim; Eriksen, Anne Kirstine; Tjonneland, Anne; Kaaks, Rudolf; Katzke, Verena; Schulze, Matthias B.; Pala, Valeria; Sacerdote, Carlotta; Tumino, Rosario; Bueno-de-Mesquita, Bas; Sanchez, Maria-Jose; Huerta, Jose M.; Barricarte, Aurelio; Amiano, Pilar; Agudo, Antonio; Bjartell, Anders; Stocks, Tanja; Thysell, Elin; Wennberg, Maria; Weiderpass, Elisabete; Travis, Ruth C.; Key, Timothy J.; Perez-Cornago, Aurora.
In: Cancer Medicine, Vol. 12, No. 4, 2023, p. 4725-4738.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Protein and amino acid intakes in relation to prostate cancer risk and mortality-A prospective study in the European Prospective Investigation into Cancer and Nutrition
AU - Schmidt, Julie A.
AU - Huybrechts, Inge
AU - Overvad, Kim
AU - Eriksen, Anne Kirstine
AU - Tjonneland, Anne
AU - Kaaks, Rudolf
AU - Katzke, Verena
AU - Schulze, Matthias B.
AU - Pala, Valeria
AU - Sacerdote, Carlotta
AU - Tumino, Rosario
AU - Bueno-de-Mesquita, Bas
AU - Sanchez, Maria-Jose
AU - Huerta, Jose M.
AU - Barricarte, Aurelio
AU - Amiano, Pilar
AU - Agudo, Antonio
AU - Bjartell, Anders
AU - Stocks, Tanja
AU - Thysell, Elin
AU - Wennberg, Maria
AU - Weiderpass, Elisabete
AU - Travis, Ruth C.
AU - Key, Timothy J.
AU - Perez-Cornago, Aurora
PY - 2023
Y1 - 2023
N2 - Background The association between protein intake and prostate cancer risk remains unclear. Aims To prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with prostate cancer risk and mortality. Methods In 131,425 men from the European Prospective Investigation into Cancer and Nutrition, protein and amino acid intakes were estimated using validated dietary questionnaires. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results During a mean follow-up of 14.2 years, 6939 men were diagnosed with prostate cancer and 914 died of the disease. Dairy protein was positively associated with overall prostate cancer risk in the three highest fifths compared to the lowest (HRQ3=1.14 (95% CI 1.05-1.23); HR(Q)4=1.09 (1.01-1.18); HRQ5=1.10 (1.02-1.19)); similar results were observed for yogurt protein (HRQ3=1.14 (1.05-1.24); HRQ4=1.09 (1.01-1.18); HRQ5=1.12 (1.04-1.21)). For egg protein intake and prostate cancer mortality, no association was observed by fifths, but there was suggestive evidence of a positive association in the analysis per standard deviation increment. There was no strong evidence of associations with different tumour subtypes. Discussion Considering the weak associations and many tests, the results must be interpreted with caution. Conclusion This study does not provide strong evidence for an association of intakes of total protein, protein from different dietary sources or amino acids with prostate cancer risk or mortality. However, our results may suggest some weak positive associations, which need to be confirmed in large-scale, pooled analyses of prospective data.
AB - Background The association between protein intake and prostate cancer risk remains unclear. Aims To prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with prostate cancer risk and mortality. Methods In 131,425 men from the European Prospective Investigation into Cancer and Nutrition, protein and amino acid intakes were estimated using validated dietary questionnaires. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results During a mean follow-up of 14.2 years, 6939 men were diagnosed with prostate cancer and 914 died of the disease. Dairy protein was positively associated with overall prostate cancer risk in the three highest fifths compared to the lowest (HRQ3=1.14 (95% CI 1.05-1.23); HR(Q)4=1.09 (1.01-1.18); HRQ5=1.10 (1.02-1.19)); similar results were observed for yogurt protein (HRQ3=1.14 (1.05-1.24); HRQ4=1.09 (1.01-1.18); HRQ5=1.12 (1.04-1.21)). For egg protein intake and prostate cancer mortality, no association was observed by fifths, but there was suggestive evidence of a positive association in the analysis per standard deviation increment. There was no strong evidence of associations with different tumour subtypes. Discussion Considering the weak associations and many tests, the results must be interpreted with caution. Conclusion This study does not provide strong evidence for an association of intakes of total protein, protein from different dietary sources or amino acids with prostate cancer risk or mortality. However, our results may suggest some weak positive associations, which need to be confirmed in large-scale, pooled analyses of prospective data.
KW - dietary amino acid intakes
KW - dietary protein intakes
KW - prostate cancer incidence
KW - prostate cancer mortality
KW - tumour subtypes
KW - GROWTH-FACTOR-I
KW - CROSS-SECTIONAL ANALYSIS
KW - ONE-CARBON METABOLISM
KW - IGF-I
KW - DIETARY QUESTIONNAIRES
KW - MEAT-EATERS
KW - EGG INTAKE
KW - ASSOCIATION
KW - METAANALYSIS
KW - RESTRICTION
U2 - 10.1002/cam4.5289
DO - 10.1002/cam4.5289
M3 - Journal article
C2 - 36148781
VL - 12
SP - 4725
EP - 4738
JO - Cancer Medicine
JF - Cancer Medicine
SN - 2045-7634
IS - 4
ER -
ID: 321254306