Severe acquired immunodeficiency in European homosexual men
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Severe acquired immunodeficiency in European homosexual men. / Gerstoft, J.; Malchow-Moller, A.; Bygbjerg, I.
In: British Medical Journal, Vol. 285, No. 6334, 01.01.1982, p. 17-19.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Severe acquired immunodeficiency in European homosexual men
AU - Gerstoft, J.
AU - Malchow-Moller, A.
AU - Bygbjerg, I.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - Four previously healthy Danish homosexual men developed Kaposi's sarcoma or opportunistic infections with fever of unknown origin and lymphadenopathy. One patient died of a Pneumocystis carinii pneumonia. Three patients had defective cell-mediated immunity with absent leucocyte interferon production and decreased proliferative response to mitogens and antigens. T lymphocyte helper subsets and natural killer cell activity were reduced. Unstimulated mononuclear cells produced leucocyte migration inhibitor factor. Two patients were sexual partners and three had never been to the USA, where cases of severe acquired immunodeficiency have been reported. Thus, the syndrome must also be suspected in European homosexual men who present with fever of unknown origin, opportunistic infections, or Kaposi's sarcoma.
AB - Four previously healthy Danish homosexual men developed Kaposi's sarcoma or opportunistic infections with fever of unknown origin and lymphadenopathy. One patient died of a Pneumocystis carinii pneumonia. Three patients had defective cell-mediated immunity with absent leucocyte interferon production and decreased proliferative response to mitogens and antigens. T lymphocyte helper subsets and natural killer cell activity were reduced. Unstimulated mononuclear cells produced leucocyte migration inhibitor factor. Two patients were sexual partners and three had never been to the USA, where cases of severe acquired immunodeficiency have been reported. Thus, the syndrome must also be suspected in European homosexual men who present with fever of unknown origin, opportunistic infections, or Kaposi's sarcoma.
UR - http://www.scopus.com/inward/record.url?scp=0019967228&partnerID=8YFLogxK
M3 - Journal article
C2 - 6805793
AN - SCOPUS:0019967228
VL - 285
SP - 17
EP - 19
JO - The BMJ
JF - The BMJ
SN - 0959-8146
IS - 6334
ER -
ID: 203863709