Soluble HLA-G and TGF-β in couples attending assisted reproduction – A possible role of TGF-β isoforms in semen?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Soluble HLA-G and TGF-β in couples attending assisted reproduction – A possible role of TGF-β isoforms in semen? / Nilsson, Line Lynge; Hornstrup, Micha B.; Perin, Trine L.; Lindhard, Anette; Funck, Tina; Bjerrum, Poul J.; Mule, Henriette Theilmann; Scheike, Thomas; Nielsen, Henriette Svarre; Hviid, Thomas Vauvert F.

In: Journal of Reproductive Immunology, Vol. 137, 102857, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nilsson, LL, Hornstrup, MB, Perin, TL, Lindhard, A, Funck, T, Bjerrum, PJ, Mule, HT, Scheike, T, Nielsen, HS & Hviid, TVF 2020, 'Soluble HLA-G and TGF-β in couples attending assisted reproduction – A possible role of TGF-β isoforms in semen?', Journal of Reproductive Immunology, vol. 137, 102857. https://doi.org/10.1016/j.jri.2019.102857

APA

Nilsson, L. L., Hornstrup, M. B., Perin, T. L., Lindhard, A., Funck, T., Bjerrum, P. J., Mule, H. T., Scheike, T., Nielsen, H. S., & Hviid, T. V. F. (2020). Soluble HLA-G and TGF-β in couples attending assisted reproduction – A possible role of TGF-β isoforms in semen? Journal of Reproductive Immunology, 137, [102857]. https://doi.org/10.1016/j.jri.2019.102857

Vancouver

Nilsson LL, Hornstrup MB, Perin TL, Lindhard A, Funck T, Bjerrum PJ et al. Soluble HLA-G and TGF-β in couples attending assisted reproduction – A possible role of TGF-β isoforms in semen? Journal of Reproductive Immunology. 2020;137. 102857. https://doi.org/10.1016/j.jri.2019.102857

Author

Nilsson, Line Lynge ; Hornstrup, Micha B. ; Perin, Trine L. ; Lindhard, Anette ; Funck, Tina ; Bjerrum, Poul J. ; Mule, Henriette Theilmann ; Scheike, Thomas ; Nielsen, Henriette Svarre ; Hviid, Thomas Vauvert F. / Soluble HLA-G and TGF-β in couples attending assisted reproduction – A possible role of TGF-β isoforms in semen?. In: Journal of Reproductive Immunology. 2020 ; Vol. 137.

Bibtex

@article{983e21cc113d4f8b86d4227939edf756,
title = "Soluble HLA-G and TGF-β in couples attending assisted reproduction – A possible role of TGF-β isoforms in semen?",
abstract = "Soluble isoforms of the non-classical Human Leukocyte Antigen (HLA)-G as well as Transforming Growth Factor (TGF)-β is expressed in seminal plasma possibly influencing the pregnancy potential. We wanted to examine the association of seminal plasma sHLA-G, TGF-β1, TGF-β2 and TGFβ3 with pregnancy success in a cohort of 127 couples and 4 single women attending fertility treatment with the use of assisted reproduction technologies (ART). Soluble HLA-G, TGF-β1, TGF-β2 and TGF-β3 in seminal plasma did not fluctuate significantly over time. We did not find any impact of seminal plasma sHLA-G, TGF-β1, TGF-β2 and TGF-β3 on time-to-pregnancy measured as number of treatment cycles. There was a significant association between concentrations of seminal plasma sHLA-G and HLA-G variations in the 3{\textquoteright}untranslated region (3{\textquoteright}UTR) of the HLA-G gene, supporting and extending previous findings. Furthermore, by comparing seminal plasma concentrations of sHLA-G, TGF-β1, TGF-β2 and TGF-β3 in male subjects with reduced semen quality, male subjects with normal semen quality, and sperm donors, we found that TGF-β2 was significantly lower, and TGF-β3 was significantly higher, in seminal plasma from sperm donors. These findings suggest that TGF-β isoforms may influence semen quality and fertility.",
keywords = "ART, HLA-G, Infertility, Reproduction, TGF-β",
author = "Nilsson, {Line Lynge} and Hornstrup, {Micha B.} and Perin, {Trine L.} and Anette Lindhard and Tina Funck and Bjerrum, {Poul J.} and Mule, {Henriette Theilmann} and Thomas Scheike and Nielsen, {Henriette Svarre} and Hviid, {Thomas Vauvert F.}",
year = "2020",
doi = "10.1016/j.jri.2019.102857",
language = "English",
volume = "137",
journal = "Journal of Reproductive Immunology",
issn = "0165-0378",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Soluble HLA-G and TGF-β in couples attending assisted reproduction – A possible role of TGF-β isoforms in semen?

AU - Nilsson, Line Lynge

AU - Hornstrup, Micha B.

AU - Perin, Trine L.

AU - Lindhard, Anette

AU - Funck, Tina

AU - Bjerrum, Poul J.

AU - Mule, Henriette Theilmann

AU - Scheike, Thomas

AU - Nielsen, Henriette Svarre

AU - Hviid, Thomas Vauvert F.

PY - 2020

Y1 - 2020

N2 - Soluble isoforms of the non-classical Human Leukocyte Antigen (HLA)-G as well as Transforming Growth Factor (TGF)-β is expressed in seminal plasma possibly influencing the pregnancy potential. We wanted to examine the association of seminal plasma sHLA-G, TGF-β1, TGF-β2 and TGFβ3 with pregnancy success in a cohort of 127 couples and 4 single women attending fertility treatment with the use of assisted reproduction technologies (ART). Soluble HLA-G, TGF-β1, TGF-β2 and TGF-β3 in seminal plasma did not fluctuate significantly over time. We did not find any impact of seminal plasma sHLA-G, TGF-β1, TGF-β2 and TGF-β3 on time-to-pregnancy measured as number of treatment cycles. There was a significant association between concentrations of seminal plasma sHLA-G and HLA-G variations in the 3’untranslated region (3’UTR) of the HLA-G gene, supporting and extending previous findings. Furthermore, by comparing seminal plasma concentrations of sHLA-G, TGF-β1, TGF-β2 and TGF-β3 in male subjects with reduced semen quality, male subjects with normal semen quality, and sperm donors, we found that TGF-β2 was significantly lower, and TGF-β3 was significantly higher, in seminal plasma from sperm donors. These findings suggest that TGF-β isoforms may influence semen quality and fertility.

AB - Soluble isoforms of the non-classical Human Leukocyte Antigen (HLA)-G as well as Transforming Growth Factor (TGF)-β is expressed in seminal plasma possibly influencing the pregnancy potential. We wanted to examine the association of seminal plasma sHLA-G, TGF-β1, TGF-β2 and TGFβ3 with pregnancy success in a cohort of 127 couples and 4 single women attending fertility treatment with the use of assisted reproduction technologies (ART). Soluble HLA-G, TGF-β1, TGF-β2 and TGF-β3 in seminal plasma did not fluctuate significantly over time. We did not find any impact of seminal plasma sHLA-G, TGF-β1, TGF-β2 and TGF-β3 on time-to-pregnancy measured as number of treatment cycles. There was a significant association between concentrations of seminal plasma sHLA-G and HLA-G variations in the 3’untranslated region (3’UTR) of the HLA-G gene, supporting and extending previous findings. Furthermore, by comparing seminal plasma concentrations of sHLA-G, TGF-β1, TGF-β2 and TGF-β3 in male subjects with reduced semen quality, male subjects with normal semen quality, and sperm donors, we found that TGF-β2 was significantly lower, and TGF-β3 was significantly higher, in seminal plasma from sperm donors. These findings suggest that TGF-β isoforms may influence semen quality and fertility.

KW - ART

KW - HLA-G

KW - Infertility

KW - Reproduction

KW - TGF-β

U2 - 10.1016/j.jri.2019.102857

DO - 10.1016/j.jri.2019.102857

M3 - Journal article

C2 - 31837543

AN - SCOPUS:85076165445

VL - 137

JO - Journal of Reproductive Immunology

JF - Journal of Reproductive Immunology

SN - 0165-0378

M1 - 102857

ER -

ID: 232134259